NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	1321-64-8
Chemical Name	Pentachloronaphthalene
Substance ID	m-nite-1321-64-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (ICSC(J) (2001)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (ICSC(J) (2001)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC(J) (2001)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on a 100% lethal dose of 1,800 mg/kg and a 100% survival dose of 600 mg/kg for rats (HSDB (Access October 2016)), this substance was classified in Category 4. 　Besides, from a report on a 100% lethal dose of 30 mg/kg and a 100% survival dose of 5 mg/kg in guinea pigs (HSDB (Access October 2016)), and a description that the mortality observed for 7 days after administration to rabbits at 500 mg/kg was 60% (CICAD 34 (2001)), this substance and chlorinated naphthalenes have possibility of large interspecies differences.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, strong dermal irritations were reported in guinea pigs dermally exposed to polychloronaphthalenes (CICAD 34 (2001)), however, this was not adopted as the evidence for classification because the cause of the irritation was not specified to be this substance. Moreover, because the information adopted in the previous classification was from List 3 information sources and the original source could not be confirmed, it was not adopted.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, irritation of the eyes was reported in workers exposed to polychloronaphthalenes, however, because it was also pointed out that there had been a possible exposure to other chemicals (CICAD 34 (2001)), it was not adopted as the evidence for classification. Moreover, because the information adopted in the previous classification was from List 3 information sources and the original source could not be confirmed, it was not adopted.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. There is no data on single exposure of this substance in humans and experimental animals. Besides, there are descriptions that chlorinated naphthalenes exhibited hepatotoxicity (CICAD 34 (2001), DFGOT vol. 13 (1997)) and description that symptoms in workers exposed to chlorinated naphthalenes included irritation of the eyes, fatigue, headache, anaemia, haematuria, anorexia, vomiting, and severe abdominal pain etc. (CICAD 34 (2001)). None of these had information on exposure times.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, skin)	Danger	H372	P260 P264 P270 P314 P501	As for humans, it is reported that chloracne was observed from trichloronaphthalenes or higher chlorinated naphthalenes (DFGOT vol. 13 (1997)), and that in dermal application to volunteers, only Halowax 1014, containing penta- and hexachloronaphthalenes, produced chloracne, and Halowaxes containing mono-, di-, tri-, tetra-, hepta-, and octachloronaphthalene did not (CICAD 34 (2001)). 　Although it is not this substance alone, in the workplace environments with mixtures of this substance and hexachloronaphthalene between 1 and 2 mg/m3, fatalities due to yellow atrophy of the liver were reported (ACGIH (7th, 2001)). It is reported that in wire manufacturing plants, contact with fabric impregnated with this substance and hexachloronaphthalenes caused chloracne (ACGIH (7th, 2001)). 　Chlorinated naphthalenes containing this substance as a major component caused numerous dermatitis cases (chloracne), a number of cases of liver damage and several deaths, and Cotter (1944) stated this substance was responsible for seven cases of toxic hepatitis, two of them fatal. Kleinfeld et al. (1972) reported on clinical findings from an examination of 59 workers exposed to tetrachloronaphthalene and this substance; 56 workers showed dermatoses consistent with chloracne resulting from skin contact, and systemic signs and symptoms including headache, fatigue, vertigo, and anorexia through inhalation of vapors (ACGIH (7th, 2001)). 　As for experimental animals, there is no report on this substance alone. 　However, in studies using rats administered by inhalation with mixtures of this substance and hexachloronaphthalene at 0.00116 mg/L for 134 days (16 hours/day) or at 0.00144 mg/L (8 hours/day) for 143 days, liver damage (enlargement of liver cells, fatty vacuolization, granulation, mitotic figures) were reported. In a study using rats administered by inhalation at 0.00088 mg/L for 134 days (16 hours/day), death, jaundice, fatty degeneration of hepatocytes, and centrilobular necrosis were reported (CICAD 34 (2001), ACGIH (7th, 2001)). 　Those were all seen at the doses within the range of Category 1. 　Besides, it is reported that in medium-term experiments, performed with technical mixtures of poly chlorinated naphthalenes in rats and guinea pigs, liver damage (mainly enlarged liver cells with increased granularity and vacuolization) etc. were found, but the higher chlorinated mixtures seemed to be more toxic (CICAD 34 (2001)). 　In addition, it is reported that studies in humans and animals demonstrated that toxicity was dependent on the congener/isomer and that it is in agreement in all the studies that the toxicity of penta- and hexa- chloronaphthalene are the strongest (CICAD 34 (2001)). 　As described above, there are few reports on this substance alone. However, chlorinated naphthalenes affected the liver and skin, and this substance and hexachloronaphthalenes are thought to be the major causal substances for toxicity of chlorinated naphthalenes. Therefore, this substance was classified in Category 1 (liver, skin).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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