NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	1321-74-0
Chemical Name	Divinyl benzene
Substance ID	m-nite-1321-74-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Flash point: 76degC(o.c.)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Type G	- -	-	-	Although the grouping relevant to autoreactive was included in the molecule but includes a polymerization inhibitors are does not polymerize in room temperatures. So it was taken as Type G.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	The ignition points is 500 degC and does not ignite in room temperatures.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods are not available.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine and chlorine.	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available on corrosion to metals	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	-	- Warning	-	-	SPECIES: Rat ENDPOINT: LD50 VALUE: 2155 mg/kg, 4100 mg/kg REFERENCE SOURCE: ACGIH (2001)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Death is not observed with 645ppm in 7 hour toxicity-by-inhalation test on rats. But there is no level of LC50, it cannot be classified.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Based on the information that it causes mild irritation on humans (ACGIH (2001)) and that it caused erythema, scaling, dropsy, and moderate necrosis on rabbits (ACGIH (2001)), it was classified as Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Since the inflammation of the conjunctiva remained even if it left on the 8th by moderate pain by applying-eyewash medication of the rabbit (ACGIH (2001)), it was set as Category 2A.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	Although there are positive results from in vivo micronucleus tests (MIN), cytogenetic assays (CAs) and sister chromatid exchange tests (SCEs), these tests are not germ cell tests. So the substance was classified as Category 2	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	It is observed mammary gland hyperplasia and bad nesting and newborns are all died in 7/9 cases in the 1000mg/kg dosage group in the oral administration of female and male rat. There was the decrease of the number of corpus luteum and the number of implantation trace, and implantation rate, and there was the decrease of the total number of baby, of the number of new born of no lactation, of the birth rate and of the number of survival baby of 4 nursing day and of the survival rate, and there was the tendency to be low of delivery rate and the neonatal reproductive rate. However, there is no effect to parent animals and new born in the dose 1000mg/kg or less (Health, Labor and Welfare Ministry reports (2006)). Since this effect is checked as secondary toxicity of parent animals because the toxicity is not occured in the next generation in the dose that parent animals do not have toxicity, it is classified into the Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 3 (narcotic effects, respiratory tract irritation)	Warning	H336 H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	In the inhalation atmospheric exposure test (7-hour single times) in five rats, nasal secretions was occured at 2340ppm exposure. In 3312ppm, ataxia, tachypnoea, eye irritation, and rhinitis were developed during exposure, and the symtoms of decreased weight and lethargic developed for more than 14 days. In 4835ppm exposure, three of five animals dead within 24 hours, and after exposure bloody urine and decreased weight were observed in the survived individual (ACGIH (2001)). Thereby, it was classified into Category 3 (anesthetic action). Moreover, the respiratory tract irritation is reported as acute symptoms by the human occupation exposures (ACGIH (2001)). So it was classified into Category 3 (respiratory irritant).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, kidney, thymus)	Warning	H373	P260 P314 P501	By the rat inhalation exposure, in the range of the value of Category 2 ,"Reduction of thymus size" is seen, moreover, "centrilobular hepatocyte growth, nephrosis, and kidney tubulars dilatation" are seen in the range of the value of Category 2 by inhalation exposure of a mouse (ACGIH (2001)).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available on chemical pneumonia	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 72-hour ErC50 = 1.83 mg/L for algae (Pseudokirchneriella subcapitata) (Ecotoxicity tests, Environment Agency, 1997; Result of the initial environmental risk assessment of chemicals, Vol. 7, Ministry of the Environment in Japan, 2009), it was classified in Category 2.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 due to lack of rapid degradability (a degradation rate by BOD: 0% (the existing chemicals survey program, 1988)), and 21-day NOEC = 0.353 mg/L for crustacea (Daphnia magna) (Ecotoxicity tests, Environment Agency, 1997; Result of the initial environmental risk assessment of chemicals, Vol. 7, Ministry of the Environment in Japan, 2009). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to lack of rapid degradability (a degradation rate by BOD: 0% (the existing chemicals survey program, 1988)), and 96-hour LC50 = 4.16 mg/L for fish (Oryzias latipes) (Ecotoxicity tests, Environment Agency, 1997; Result of the initial environmental risk assessment of chemicals, Vol. 7, Ministry of the Environment in Japan, 2009). It was classified in Category 2 from the above results.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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