Item | Information |
---|---|
CAS RN | 1332-21-4 |
Chemical Name | Asbestos |
Substance ID | m-nite-1332-21-4_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Accessed Oct. 2018)). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Accessed Oct. 2018)). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (GESTIS (Accessed Oct. 2018)). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Because there is an observation result that it is insoluble in water (GESTIS (Accessed Oct. 2018)), it is estimated that it does not react vigorously with water. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen, but the classification is not possible due to no data. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic compound. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Solid (GHS definition) |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Solid (GHS definition) |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] It was classified in Category 2 based on (1) and (2). [Evidence Data] (1) Asbestos may induce genotoxicity directly by catalysing the generation of reactive oxygen species. Also, it is possible to physically interfere with the mitotic apparatus of the cell and this may result in aneuploidy of chromosomes and specific chromosomal alterations (IARC 100C (2012)). (2) There are several types of asbestos. Among them, 3 types of asbestos, amosite (CAS: 12172-73-5), chrysotile (CAS: 12001-29-5), crocidolite (CAS: 12001-28-4) have large numbers of test data. For these 3 types, positive results were obtained in in-vitro tests: chromosomal aberration tests, micronucleus tests, and sister chromatid exchange tests (ATSDR (2001)). [Reference Data, etc.] (3) There is no test result of in vivo germ cell mutagenicity nor in vitro test result for asbestos (CAS: 1332-21-4) (ATSDR (2001), IARC 110C (2012)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Category 1A |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] It was classified in Category 1A based on (1) and (2). [Evidence Data] (1) Based on numerous epidemiological evidence and test results in experimental animals, IARC concluded that there is sufficient evidence in humans and experimental animals for the carcinogenicity from all 6 types of asbestos (amosite, chrysotile, crocidolite, tremolite, actinolite, anthophyllite) (IARC 100C (2012)). (2) Based on (1), IARC classified carcinogenicity from all 6 types of asbestos in Group 1 (IARC 100C (2012)). Other than this, all the 6 types of asbestos are classified as A1 by ACGIH (ACGIH (7th, 2001)), and the carcinogenicity of asbestos is classified in Group 1 by Japan Society For Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (2018): proposed in 1981), as A by EPA (IRIS (1988)), as K by NTP (NTP RoC (14th, 2016)) and in Carc. 1A by EU CLP. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] It is reported that no effects on the fertility of the parent animals were observed after dietary administration of amosite, chrysotile and crocidolite as shown in (1), and that no developmental effect was observed by administration during the gestational period for chrysotile as shown in (2). However, there is no description of the general toxic effects on parental animals, so it is not possible to judge whether the dose given to the parental animals is sufficient. Therefore, it could not be classified as "Not classified" based on the results of (1) and (2) alone, so it was classified as "Classification not possible." [Evidence Data] (1) No reproductive effects were observed for the 3 types of asbestos, amosite, chrysotile and crocidolite, in diet administration tests with rats and hamsters (ATSDR (2001)). (2) As for the developmental toxicity test with pregnant animals dosed orally (by drinking water), it was reported that no developmental effect was detected with chrysotile (ATSDR (2001)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
[Rationale for the Classification] As for the acute effect of this substance, there is no report on either humans or experimental animals. However, based on the test data of chrysotile in (1), it is considered that serious respiratory lesions such as pulmonary fibrosis occur as a delayed effect after a single inhalation exposure within the range of Category 1 in experimental animals, although the onset time is unknown. Therefore, this substance was classified in Category 1 (respiratory organs) as a medium to long-term effect of single exposure. Besides, the classification was changed using the data of this one type of asbestos. [Evidence Data] (1) There is a report that pulmonary fibrosis occurred as a result of inhalation exposure to chrysotile with mice for 5 hours at the concentration of 132 fibers/mL (equivalent to 4 mg/m3, converted 4-hour equivalent value: 0.005 mg/L) within the range of Category 1 (ATSDR (2001)). [Reference Data, etc.] (2) Although it is data from another hazard class (carcinogenicity), as a result of single inhalation exposure to a standard sample (UICC/A) of this substance with rats for 7 hours at the concentration of 14.7 mg/m3 (converted 4-hour equivalent value: 0.026 mg/L) within the range of Category 1, thoracic tumors were observed in 5/45 animals (11%) (IARC 110C (2012)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 | P260 P264 P270 P314 P501 |
[Rationale for the Classification] It was classified in Category 1 (respiratory organs) based on (1)-(3). [Evidence Data] (1) As for three types of asbestos, amosite, chrysotile, and crocidolite, for which there are many test reports, among major kinds of asbestos, a variety of respiratory lesions are reported in a number of epidemiologic studies of workers who had been exposed to single or multiple types of those three types for a long time. Findings of respiratory lesions include various reports from anomalies of the lung parenchyma detected by chest x-rays and pleura thickening, etc., or cases diagnosed as pulmonary fibrosis, to cases of fatal asbestosis, or cases of chronic pharyngitis (ATSDR (2012)). (2) All types of asbestos are known to cause asbestosis, pleura changes and neoplastic lesions. However, based on the experimental and epidemiologic results, it is considered that there are differences in the potential of the different asbestos types to produce respiratory disease, and that crocidolite has the greatest potential, chrysotile has the smallest, and amosite occupies an intermediate position (ACGIH (7th, 2001)). (3) As for experimental animals, an increase in pulmonary fibrosis was observed as a result of inhalation exposure to this substance for one or two years with rats (ATSDR (2012)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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