NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	1335-88-2
Chemical Name	Tetrachloronaphthalene
Substance ID	m-nite-1335-88-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	It is combustible (ICSC(J) (2001)), but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	Because it is reported that there is no autoignition temperature to a boiling point (311.5-360 deg C) (HSDB (Access on October 2016)), it is estimated that it does not ignite at normal temperatures.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data. It was described in CICAD 34 (2001) that the LD50 of 2,3,6,7-tetrachloronaphthalene (CAS RN 34588-40-4) for guinea pigs was >3 mg/kg. It corresponded to Category 1 - "Not Classified," however, only from this value, the category cannot be determined.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Strong dermal irritations were reported in guinea pigs dermally exposed to polychloronaphthalenes (CICAD 34 (2001)), however, it was not adopted as the evidence for classification because the cause of the irritation was not specified to be this substance.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Irritation of the eyes was reported in workers exposed to polychloronaphthalenes, however, because it was pointed out that there had been possible exposure to other chemicals (CICAD 34 (2001)), it was not adopted as the evidence for classification.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	There was no in vivo data. As for in vitro data, a bacterial reverse mutation test was negative (CICAD 34 (2001), DFGOT vol. 13 (1997), HSDB (Access on August 2016), NTP DB (Access on August 2016)). From the above, according to the GHS classification guidance for the Japanese government, the substance was classified as "Classification not possible."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. There was no data with regard to single exposure of this substance in humans and experimental animals. There were descriptions that chlorinated naphthalenes exhibited liver toxicity (CICAD 34 (2001), DFGOT Vol. 13 (1997)) and, description that symptoms in workers exposed to chlorinated naphthalenes included irritation of the eyes, fatigue, headaches, anaemia, haematuria, anorexia, vomiting, and severe abdominal pain etc. (CICAD 34 (2001)). None of these had information on the number of exposure times.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, skin)	Danger	H372	P260 P264 P270 P314 P501	There was no information with regard to this substance as a single substance. 　Besides, for humans, severe skin reactions (chloracne) and liver disease both were reported after occupational exposure to chlorinated naphthalenes (CICAD 34 (2001), DFGOT vol. 13 (1997), ACGIH (7th, 2001)). The toxicity varies depending on the number of chlorine atoms, it was reported that studies in humans and animals showed that toxicity was dependent on the congener/isomer and that there was agreement in all the studies that the penta- and hexa- naphthalenes were the most toxic (CICAD 34 (2001)). 　Among these, with regard to the effects on the skin, it was reported that chloracne was observed with trichloronaphthalenes and higher chlorinated naphthalenes (DFGOT vol. 13 (1997)). 　It was reported that the incidence and severity of chloracne were less when trichloronaphthalene (usually mixed with some of this substance) was used rather than when penta- and hexachloronaphthalene were present (ACGIH (7th, 2001)). It was also reported that dermal application to volunteers caused chloracne only in Halowax 1014, containing penta- and hexachloronaphthalenes and that Halowaxes containing mono-, di-, tri-, tetra-, hepta-, and octachloronaphthalenes did not (CICAD 34 (2001)). 　With regard to the effects on the liver, as information in which the substance is identified to some extent, a non-fatal case of hepatitis induced by occupational exposure to trichloronaphthalene (this substance was probably also present (CICAD 34 (2001)) at 3mg/m3 was reported (ACGIH (7th, 2001)). On the other hand, as for higher chlorinated congeners, it was reported that mixtures of pentachloronaphthalene and hexachloronaphthalene at the concentration of 1 to 2 mg/m3 in workplace environments, caused fatal cases of yellow atrophy of the liver to occur (ACGIH (7th, 2001)). 　As for experimental animals, in toxicity tests using rats in inhalation of trichloronaphthalene and small amounts of this substance for 2.5 months (1,232 hours) or 4 months (1,896 hours), very slight swelling of the liver at 0.0013 mg/L and hepatic hypertrophy with granulocytosis and mitotic figures at 0.011 mg/L were observed within the range of Category 1 (ACGIH (7th, 2001)). 　Besides, it was reported that in medium-term experiments performed with technical mixtures of polychloronaphthalenes in rats and guinea pigs, liver damage (mainly enlarged liver cells with increased granularity and vacuolization) etc. were found and the higher chlorinated mixtures appeared to be more toxic (CICAD 34 (2001)). 　As described above, chlorinated naphthalenes affected the liver and skin, and pentachloronaphthalene which has five chlorine atoms and hexachloronaphthalenes which has six chlorine atoms were thought to be the major causal substances for toxicity from chlorinated naphthalenes. There was no information on this substance as of single substance, however, because chloracne was reported in humans from mixtures of this compound containing lower chlorinated congeners, and as the effects on the liver were observed at doses corresponding to Category 1 in experimental animals, the substance was classified in Category 1(liver, skin).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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