NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	1344-48-5
Chemical Name	Mercury(II) sulfide
Substance ID	m-nite-1344-48-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on August 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on August 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (GESTIS (Access on August 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It is estimated that it does not react vigorously with water due to the observation result of being insoluble in water (CICAD 50 (2003)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an inorganic substance not containing oxygen or halogen.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1A	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Mercury and its compounds are designated as Group 1 of occupational skin sensitizer in Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2016). In addition, it is described that patch tests in humans show cross-reactivity between various inorganic and organic forms of mercury (CICAD 50 (2003), ATSDR (1999)). Therefore, the substance was classified in Category 1A.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	For metallic mercury and inorganic mercury compounds, IARC classified them in Group 3 (IARC 58 (1993)), and ACGIH classified in A4 (ACGIH (7th, 2001)). Therefore, it was classified as "Classification not possible." 　Besides, there is a history that EPA classified inorganic mercury compounds as Group C (possible human carcinogen) based on the carcinogenicity test data of mercuric chloride (II) (EPA Technology Transfer Network (Access on July 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	No data available for the effects on reproduction of this substance itself. 　As for reports on the developmental effects of inorganic mercury compounds, as a result of administration of mercury acetate or mercury chloride (II) to pregnant mice or pregnant hamsters by oral or parenteral route (subcutaneous, intraperitoneal, intravenous administration), increased incidence of malformations (cleft palate, hydrocephalus) and abnormal fetuses (dwarf, edematous fetuses) and increased embryonic resorptions and fetal death, etc. were reported (CICAD 50 (2003)). On the other hand, although intake amount was unspecified, elevated mercury urine levels were observed in two subjects who ingested this substance (ATSDR (1999)). In mice orally given mercury chloride (II) or this substance, mercury levels in the tissues were increased, but the degree of increase was greater with mercury chloride (II) (ATSDR (1999)). From these findings, it is suggested that this substance is absorbed somewhat by oral administration. Therefore, an increase in the occurrence of malformations by this substance can also be sufficiently considered in experimental animals on oral route. Moreover, the Japan Society for Occupational Health classified inorganic mercury including mercury vapor in reproductive toxicants group 2 (equivalent to Category 1B) (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health, 2016)). 　Therefore, based on the findings in laboratory animals and the classification result of the Society of Occupational Health, this substance was classified in Category 1B for this hazard class.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, peripheral nervous system, kidney, gastrointestinal tract)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	This substance is an inorganic mercury compound that is insoluble in water, but there is no data available on single exposure in humans or laboratory animals. Although they were not the data of this substance, it is reported that metallic mercury or other inorganic mercury compounds caused nausea, vomiting, diarrhea, tremor, central nervous system depression, emotional instability/irritability, peripheral neuropathy, gingivitis, stomatosis, vision changes, hearing loss, and renal impairment in humans (unspecified route) (ACGIH (7th, 2001)) and that the cause of death from oral exposure was renal failure, cardiovascular collapse, and severe gastrointestinal disorder, and the most common findings were gastrointestinal lesions and renal failure (CICAD 50 (2003)). In experimental animals, neurophysiological effects, electrophysiological effects and effects on the kidney, and behavior effects were observed in the exposure to metallic mercury or other inorganic mercury compounds (ACGIH (7th, 2001)). From the above, it is considered reasonable to classify this substance based on toxicity information of metallic mercury and other inorganic mercury compounds. Therefore, this substance was classified in Category 1 (central nervous system, peripheral nervous system, kidney, gastrointestinal tract).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system, kidney)	Danger	H372	P260 P264 P270 P314 P501	No hazardous findings of repeated exposure to this substance were available either for human or experimental animals. However, as for the findings of repeated exposure to inorganic mercury compounds, in multiple cases of humans who ingested mercury chloride (mainly mercury chloride (II)) (ATSDR (1999)) and in many studies in which mercury chloride (II) was orally administered to rats or mice for 2 weeks to 2 years (CICAD 50 (2003)), the effect on the kidney (renal failure (human), nephropathy, degeneration of renal tubular epithelium, glomerular thickening (rat, mouse)) were observed. From these findings, it was considered that the kidney was the target organ. Moreover, it is reported that central nervous symptoms (excitement, sleeplessness, muscle twitching, etc.) were seen in multiple case reports of humans who ingested medicines containing mercuric chloride, and chronic intoxication cases showed development of dementia and irritability, and at necropsy of a few death cases, a decrease in the weight and volume of the brain and a decrease in the number of neurons in the cerebellum were seen, and accumulation of mercury was confirmed in neurons by electronic microscopy observation (ATSDR (1999)). From the above, it was considered reasonable to conduct GHS classification of this substance by referring to the hazardous findings of inorganic mercury compounds such as mercuric chloride, therefore, this substance was classified in Category 1 (central nervous system, kidney).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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