NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	13446-34-9
Chemical Name	Manganese(II) chloride tetrahydrate
Substance ID	m-nite-13446-34-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on November 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on November 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (GESTIS (Access on November 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains a metal (Mn), but it is estimated that it does not react vigorously with water because the measurement result of water solubility 1,980 g/L were obtained (GESTIS (Access on November 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified	- -	-	-	The substance is an inorganic compound containing oxygen and chlorine. Oxygen is from crystalline water, and chlorine is a chlorine ion, both of which do not contribute to oxidation.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Classification not possible	- -	-	-	It is an inorganic compound.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on a report of an LD50 value of 7.5 mmol/kg (converted LD50 value with a molecular weight of 197.9: 1,484 mg/kg) (Holbrook DJ Jr. et al.: Environ Health Perspect., 10, 95 (1975)), this substance was classified in Category 4. 　As for the following health hazard classes, please refer to also manganese chloride (II) (CAS RN 7773-01-5), which is the anhydrous substance of this substance.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	As for in vivo tests, it was negative in chromosomal aberration tests using spermatogonial cells and bone marrow cells of rat (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999), ATSDR (2012)). As for in vitro tests, positive and negative results were reported in bacterial reverse mutation tests; a mouse lymphoma test of cultured mammalian cells, and a chromosome aberration test of human lymphocyte cultured cells were positive (ATSDR (2012)). From the above, this substance was classified as "Classification not possible" in accordance with the GHS Classification Guidance for the Japanese Government.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Data is not available for this substance itself. However, as the data on divalent soluble manganese compounds, there is a carcinogenicity test report by NTP, in which manganese sulfate monohydrate was administered in the diet to rats or mice for 2 years. There was no evidence of carcinogenicity in both male and female rats, but in mice, there was a slight increase in thyroid follicular cell adenoma in both males and females. It was concluded by NTP that the evidence of carcinogenicity was equivocal (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), NTP TR428 (1993), CICAD 12 (1999), ATSDR (2012)).There is no classification result for manganese compounds by other organizations. Therefore, the classification of this substance for this hazard class was not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a test in which this substance was subcutaneously administered to pregnant mice (Gestation days 6 to 15), at doses in which suppression of maternal weight gain and reduction in feed intake were observed in maternal animals or even at lower doses, increased embryo resorptions, hypoplasia of the kidney, and wavy ribs were observed in the fetuses (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999)). In a test in which manganese chloride was intravenously administered to pregnant rats during organogenesis (Gestation Days 6 to 17), fetal death, skeletal abnormality, wavy ribs, and bending of limbs were observed even at doses lower than that at which the maternal toxicity (suppression of body weight gain, implantation number reduction) was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999)). In addition, it is also reported that increased exencephaly and embryo resorptions were observed in a single intraperitoneal administration of manganese sulfate to pregnant mice on the 8th day of gestation, and at higher doses, inhibition of implantation was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). On the other hand, in a test in which manganese chloride was administered in the drinking water to pregnancy rats, throughout the pregnant period, even at doses exceeding the expression of maternal toxicity (suppression of body weight gain, decrease in water intake), low body weight of the offspring was the only observation seen (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). 　As described above, although it is limited to some extent, the toxicity information of the divalent soluble manganese compounds including this substance showed skeletal abnormalities, external malformation, inhibition of implantation, etc. in the fetuses through injection routes such as subcutaneous, intravenous or intraperitoneal injection. Therefore, it was deemed appropriate to classify this substance in Category 2.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	Although it is not regarding this substance, when humans are exposed to excess amounts of manganese, by the oral or inhalation route, effects such as memory disorders or psychiatric symptoms were observed as acute effects. As for chronic effects, symptoms of manganese addict similar to those of Parkinson's disease were seen, such as gait disturbance and language disorders. Serious effects were observed especially in inhalation exposure (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As for the oral route, in cases of drinking well water containing high concentrations of manganese, and in epidemiological investigations on residents living in regions with high manganese concentration, symptoms similar to manganese addiction symptoms such as mask-like faces, muscle rigidity, tremors and psychiatric disorders were reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). The influence on the neurobehavioral function by exposure to the dust of manganese dioxide, trimanganese tetraoxide, and manganese salts (sulfate, carbonate, nitrate) at plants manufacturing manganese oxides and manganese salts were reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Occurrence of neurotoxicity due to manganese poisoning has been reported as a result of occupational exposure to manganese dioxide. In addition to impaired visual reaction time and hand-eye coordination, rigidity of the hands has been observed (SIDS (2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2012)). Furthermore, many cases revealed that manganese compounds, mainly manganese dioxide, produce respiratory disorders (cough, bronchitis, pneumonia, etc.) (ATSDR (2012)). 　As for experimental animals, it is reported that in a 60-day repeated dose toxicity test by gavage using young rats of 3 weeks of age, at doses of 0.31 mg/kg/day (converted guidance value: 0.21 mg/kg/day), which corresponds to Category 1, increased brain monoamine oxidase activity and neurodegeneration in the cerebellar and cerebral cortex and caudate nucleus were observed (ATSDR (2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). In addition, in a 10-week toxicity test using rats dosed with this substance in the drinking water, at doses of 6.5 mg/kg/day, which is equivalent to Category 1, decreases in spatial memory performance, open field locomotor activity and acoustic startle response, and increased latency of sensory evoked potentials were reported (ATSDR (2012)). 　Therefore, this substance was classified in Category 1 (nervous system, respiratory organs).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	From 72-hour ErC50 = 82 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2008)), it was classified in Category 3.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Due to unknown environmental dynamics of the inorganic compound, and 21-day NOEC (reproduction) = 0.16 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2008)), it was classified in Category 2.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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