Item | Information |
---|---|
CAS RN | 13464-38-5 |
Chemical Name | Sodium arsenate |
Substance ID | m-nite-13464-38-5_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Not classified |
- |
- | - | Since sodium arsenate dibasic (CAS 7778-43-0, ID 20A2355) is not combustible (ICSC, 1999), we estimated that this substance is also non-combustible. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Not combustible. Since sodium arsenate dibasic (CAS 7778-43-0, ID 20A2355) is not combustible (ICSC, 1999), we estimated that this substance is also non-combustible. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | Not combustible. Since sodium arsenate dibasic (CAS 7778-43-0, ID 20A2355) is not combustible (ICSC, 1999), we estimated that this substance is also non-combustible. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is stable in contact with water. (It is readily soluble in water according to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001).) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | Given its substance-specific UN No. 1685, the substance is rated as Division 6.1, II; not Division 5.1, by the UNRTDG, which indicates oxidizing substances. Despite this information, due to lack of additional data, classification is not possible. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Inorganic compound | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
Since the LD50 for rats is 112 mg/kg (DFGOT 21, 2005), the substance was classified into Category 3. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Inorganic arsenic compounds are reported to cause irritation (DFGOT vol. 21, 2005). However, since no further information is available, classification is not possible. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
Since inorganic arsenic compounds are reported to irritate human eyes (HSG 70, 1992; PIM 042, 1996), this substance was classified into Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Not classified |
- |
- | - | Since this substance was not allergenic in the guinea pig maximization test (positive reaction rates: 0-8%) (Initial Risk Assessment Report (NITE, CERI, NEDO) (2008); EHC 224 (2001)), it was classified into the "Not classified" category. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | In vitro tests (mouse lymphoma assays and transformation assays (Initial Risk Assessment Report (NITE, CERI, NEDO) (2008)) gave positive results. However, due to insufficient test results available, classification is not possible. According to MAK/BAT (2007), arsenic and its inorganic compounds are classified into Category 3A for germ cell mutagenicity (which is equivalent to Category 1B to 2 in the GHS classification). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Category 1A |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
According to IARC Suppl. 7 (1987), ACGIH-TLV (2008), and MAK/BAT (2007), arsenic and its inorganic compounds are categorized as human carcinogens. Thus, the substance was classified into Category 1A. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
Hamsters that received intravenous administration (EHC 224, 2001) and mice that underwent intraperitoneal administration (Initial Risk Assessment Report (NITE, CERI, NEDO) (2008)) showed signs of developmental toxicity (increased incidences of malformations in the neural tube). In addition, according to description for arsenic and arsenic compounds documented in EHC 224 (2001) which is a List 1 information source, these substances are suggested to affect human reproduction (increased fetal, neonatal and postnatal mortality, spontaneous abortions, and congenital malformations, etc.) and have teratogenic effects at doses that are toxic to maternal animals. Thus, the substance was classified into Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Category 1 (gastrointestinal system, circulatory system, nervous system, blood system, respiratory organs, skin, kidney, liver) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
Nephrotoxic effect was seen in a dog that underwent intravenous administration (EHC 224, 2001). In humans, the following acute toxic effects by arsenic compounds are documented: symptoms of the gastrointestinal tract, cardiovascular system, nerves, and blood system; conjunctivitis and dermatitis as well as irritation to the nasal mucosa, pharynx, and trachea; frequent urination or anuria due to a blockage of renal tubules with clots of hemoglobin (IARC 23 (1980)); depression of bone marrow functions; and hepatomegaly (EHC 224 (2001)). In accordance with these reports, the digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, and liver were considered to be target organs of these compounds, and this substance was classified into Category 1 (digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, and liver). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (gastrointestinal system, circulatory system, nervous system, kidney, liver, blood system, respiratory system, skin) |
Danger |
H372 | P260 P264 P270 P314 P501 |
Alterations in kidney and liver were observed in rats exposed to this substance (dose: approx. 4 mg/kg bw/day) repeatedly for 320 days (EHC 224, 2001; Initial Risk Assessment Report (NITE, CERI, NEDO), 2008). In addition, according to EHC 224 (2001) on arsenic and its inorganic compounds in relation to humans, gastrointestinal tract disorder; nervous disorder; effects on the blood system; and abnormalities in cardiovascular system, kidney, and liver were observed. Thus, target organs for these substances are the gastrointestinal tract, heart, brain, and kidney. In addition, the skin, bone marrow and peripheral nervous system are also affected by these substances. Moreover, according to ACGIH (2001), the upper respiratory tract and lung are also affected. Based on these reports, this substance was classified into Category 1 (digestive system, circulatory system, nervous system, kidney, liver, blood system, respiratory system, and skin). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified into Category 1 from 96-hour EC50=159.3microg/L of algae (Scenedesmus) (AQUIRE, 2003). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Classified into Category 1, since acute toxicity was Category 1, and it is a metallic compound, behavior in water and bioaccumulative potential are unknown. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
|