Item | Information |
---|---|
CAS RN | 13464-82-9 |
Chemical Name | Indium(III) sulfate |
Substance ID | m-nite-13464-82-9_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Classification not possible |
- |
- | - | Although it is estimated to be not combustible, the classification is not possible due to no data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | Although it is estimated to be not combustible, the classification is not possible due to no data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Although it is estimated to be not combustible, the classification is not possible due to no data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that it does not react vigorously with water due to the observation result of water solubility (117 g/1,000 g (20 deg C), Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013)). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen, but the classification is not possible due to no data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic compound. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, an LDLo value of 1,200 mg/kg for rats was reported (PATTY (6th, 2012)) and this value suggests Category 4 or above, however, the classification is not possible only from this data. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is described that indium and its compounds are irritants to skin (HSDB (Access on June 2016)), however, the source of this report is listed as List 2 and the original source of this information was not confirmed. Therefore, it was not adopted as the evidence of the classification. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
It is described that the soluble indium salts are very irritating to the eyes (ACGIH (7th, 2001)), therefore this substance was classified in Category 2A. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | There is no information related to carcinogenicity of the substance itself. Therefore, classification was not possible due to lack of data. Besides, as described in the same hazard class of the GHS classification of indium oxide (CAS RN 1312-43-2), as results of the classification by other organizations of related compounds, indium phosphide is classified in Group 2A by IARC (IARC 86 (2006)) and hardly soluble inorganic indium compounds are classified in Category 2A by the Japan Society For Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (2015)). However, since this substance is a soluble compound, these classifications cannot be adopted. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. No studies regarding a single exposure of humans to indium sulphate are reported. As for experimental animals, the LDLo value of oral administration for rabbits was 1,300 mg/kg and spastic paralysis, gastrointestinal tract necrotic changes, and interstitial nephritis occurred by gastrointestinal tract absorption (PATTY (6th, 2012)). It is reported that the LDLo value of oral administration for rats was 1,200 mg/kg and ulceration or bleeding of the stomach and necrosis of the gastrointestinal tract occurred (PATTY (6th, 2012)). However, information regarding doses is not enough to make a decision for classification. Besides, it is described in the Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), that Indium is irritating to the respiratory tract, but this information is from ICSC, so the original source cannot be confirmed. Also, it is not clear whether this description is regarding only metallic indium or indium compounds. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | No information regarding this substance is available. Besides, there is a report that indium chloride (III) (CAS RN 10025-82-8), which is also a soluble indium compound as well as this substance, caused decreased weight gain at 1,200 and 2,000 mg/kg/day in a 3-month repeated dose toxicity test using rats given by feeding (PATTY (6th, 2012), Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)), however, there is no data regarding inhalation route. However, in a single exposure test (doses: 0.2, 2.0, 20 mg/m3) in which rats were exposed to an aerosol of indium (III) chloride for 1 hour, in proportion to the level of lung injury at 7th day after exposure, an restrictive lung lesion and increased airway sensitivity to acetylcholine were observed. Moreover, the lung collagen levels at 42 days after the exposure increased, depending on the exposure concentration. It is reported that these results indicate that exposure to indium (III) chloride is the cause of acute pulmonary inflammation (Japan Society For Occupational Health (JSOH) Recommendation of Occupational Exposure Limits Vol.49 (2007), Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)). As for indium (III) nitrate (CAS RN 137770-61-1), which is also a soluble indium compound, it is reported that in a 20-week study (unknown frequency) on the oral route using rabbits, diffuse hepatocellular necrosis and changes in spleen weight and in blood occurred at 21,920 mg/kg (PATTY (6th, 2012)). However, the details are unknown, and there is no data by the inhalation route. As described above, there is no information on this substance and information on soluble indium compounds which is similar to this substance is insufficient. Therefore it was classified as "Classification not possible" due to lack of data. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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