Item | Information |
---|---|
CAS RN | 13477-10-6 |
Chemical Name | Dihypochlorous acid barium salt |
Substance ID | m-nite-13477-10-6_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It was classified as "Not classified" because it is classified in Division 5.1, PG II in UNRTDG (UN2741), and it is considered to be not applicable to pyrophoric substances, hazards of the highest precedence. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains a metal (Ba), but it was classified as "Not classified" because it is estimated that it does not react vigorously with water from obtained data: it is slightly soluble in water (HSFS (2001)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Category 2 |
Danger |
H272 | P370+P378 P210 P220 P280 P501 |
It was classified in Category 2 because it is classified in Division 5.1, PG II in UNRTDG (UN2741). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Inorganic compound. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
[Rationale for the Classification] There were no data on this substance itself, but it was classified in Category 1 from (1). The classification result was changed based on new information. [Evidence Data] (1) In the same way that calcium hypochlorite (CAS RN 7778-54-3) is corrosive to the skin due to the alkalinity of the hypochlorite ion (AICIS (formerly, NICNAS) IMAP (2015)), this substance was considered to be corrosive to the skin. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
[Rationale for the Classification] It was classified in Category 1 from (1). The classification result was changed based on new information. [Evidence Data] (1) This substance was classified in Category 1 in skin corrosion/irritation (GHS classification result in FY2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There was no information on this substance itself, but because this substance was considered to dissociate into the hypochlorite ion and barium ion in aqueous solutions, an investigation was conducted based on information on sodium hypochlorite (CAS RN 7681-52-9) and barium chloride, dihydrate (CAS RN 10326-27-9). From (1) - (4), it was classified as "Classification not possible" due to lack of in vivo data on barium chloride, dihydrate. [Evidence Data] (1) As for in vivo data on sodium hypochlorite (CAS RN 7681-52-9), it was reported to be negative in micronucleus tests using the bone marrow after intraperitoneal or oral administration to mice, negative in a chromosomal aberration test using the bone marrow after oral administration to mice, and negative in a DNA damage test after oral administration to rats (EURAR (2007), NTP TR392 (1992), Patty (6th, 2012)). (2) As for in vitro data on sodium hypochlorite, it is reported that bacterial reverse mutation tests gave negative and positive results, chromosomal aberration tests with cultured mammalian cells gave negative and positive results (EURAR (2007), NTP TR392 (1992)), and a sister chromatid exchange test with cultured mammalian cells was positive (EURAR (2007)). (3) There were no in vivo data on barium chloride, dihydrate (CAS RN 10326-27-9). (4) As for in vitro data on barium chloride, dihydrate, it was reported to be negative in a bacterial reverse mutation test, and a chromosomal aberration test and a sister chromatid exchange test (SCE) with cultured mammalian cells, and positive in a mouse lymphoma test (CEBS (Access on August 2019), NTP TR432 (1994)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Not classified |
- |
- | - | [Rationale for the Classification] No classification results by domestic and international organizations or carcinogenicity reports were obtained for this substance, but because this substance was considered to dissociate into the hypochlorite ion and barium ion in aqueous solutions, it was classified as "Not classified" from classification results by other organizations in (1) and carcinogenicity test results in experimental animals for sodium hypochlorite in (2) and (3). [Evidence Data] (1) As for classification results by domestic and international organizations, ACGIH classified barium and soluble barium compounds in A4 (ACGIH (7th, 2001)). And IARC classified hypochlorite salts in Group 3 (IARC 52 (1991)), although this substance was not included. (2) In a 104-week drinking water administration test in rats and a 103-week drinking water administration test in mice both using sodium hypochlorite (CAS RN 7681-52-9), no significant increase in tumor incidences was observed (IARC 52 (1991)). (3) In a carcinogenicity test with mice using sodium hypochlorite in the dermal route, no carcinogenicity was seen (IARC 52 (1991)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There were no data on this substance, however, since this substance was considered to dissociate into hypochlorite ions and barium ions in aqueous solution, classification was made based on the data of hypochlorous acid (CAS RN 7790-92-3) and water-soluble barium. Based on the data of hypochlorous acid, it could be considered that there were generally no reproductive effects, however, since there were no data on developmental toxicity when administerted only during the organogenesis period, it was determined that classification was not possible due to lack of data. As for barium ions, classification was not possible. From the above, classification was not possible due to lack of data. [Evidence Data] (1) In a one-generation reproduction toxicity study by oral administration of hypochlorous acid to rats dosed by gavage, there were no clinical signs of toxicity, hematological changes, body weight depression, alterations in sperm count, sperm motility, or sperm morphology, or histopathological lesions in the reproductive organs, and there were no dose-related effects on fertility, fetal viability, litter size, fetal body weight, day of eye opening, or day of vaginal patency (EURAR (2007), AICIS (previous NICNAS) IMAP (2014)). (2) In a test by oral administration of hypochlorous acid to female rats dosed by drinking water from 2.5 months before mating through the gestation period, no maternal toxicity or developmental toxicity was observed (EURAR (2007), AICIS (previous NICNAS) IMAP (2014)). (3) In the EURAR (2007), there were no data of sodium hypochlorite (CAS RN 7681-52-9). However, it was reported that, although the data available were limited, the results of the animal studies using hypochlorous acid and chlorine could draw the conclusion that there was no evidence to suggest that sodium hypochlorite would present adverse effects on development of the next generation or fertility. It was stated that, similarly, no such evidence was obtained from epidemiological studies on populations consuming chlorinated drinking water (EURAR (2007)). (4) As for reproductive effects of barium salt, classification was not possible due to lack of information for barium chloride (CAS RN 10361-37-2) and barium carbonate (CAS RN 513-77-9) (GHS Classification Results in FY2014). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, cardiovascular system, muscle, digestive organ), Category 3 (respiratory tract irritation) |
Danger Warning |
H370 H335 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
[Rationale for the Classification] There was no information on this substance, however, since this substance was considered to dissociate into hypochlorite ions and barium ions in aqueous solution, examination was carried out based on the information on sodium hypochlorite (CAS RN 7681-52-9) and water-soluble barium compounds. Based on (1) to (4), it was classified in Category 1 (nervous system, cardiovascular system, muscle, digestive organs) and Category 3 (respiratory tract irritation). New information sources were used and the classification results were changed from the previous classification. [Evidence Data] (1) It was reported that barium and its soluble compounds caused irritation of the eyes and skin, gastrointestinal distress including nausea, vomiting, colic, and diarrhea, and myocardial and other adverse muscular stimulation (ACGIH (7th, 2001)). (2) It was reported that poisoning by barium in humans included acute gastroenteritis, loss of deep reflexes with onset of muscular paralysis, and progressive muscular paralysis (EHC 107 (1990)). (3) It was reported that, in rats, the effects of barium ingestion included salivation, nausea, diarrhea, tachycardia, hypokalemia, twitching, flaccid paralysis of skeletal muscle, respiratory muscle paralysis, and ventricular fibrillation (EHC 107 (1990)). (4) The specific target organ toxicity (single exposure) of sodium hypochlorite (CAS RN 7681-52-9) was Category 3 (respiratory tract irritation) (GHS Classification Results in FY2020). [Reference Data, etc.] (5) The specific target organ toxicity (single exposure) of barium carbonate (CAS RN 513-77-9) was Category 1 (nervous system, cardiovascular system, muscular system) and Category 3 (respiratory tract irritation) (GHS Classification Results in FY2014). (6) The specific target organ toxicity (single exposure) of barium chloride (CAS RN 10361-37-2) was Category 1 (nervous system, cardiovascular system, muscular system, kidney) and Category 3 (respiratory tract irritation) (GHS Classification Results in FY2006). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (cardiovascular system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
[Rationale for the Classification] There was no information on this substance itself, however, since this substance was considered to dissociate into hypochlorite ions and barium ions in aqueous solution, examination was carried out based on the information on sodium hypochlorite (CAS RN 7681-52-9) and water-soluble barium compounds. Based on (3) and (4), repeated dose toxicity of sodium hypochlorite in the oral and dermal routes was considered to be low, but based on the information of water-soluble barium compounds in (1) and (2), it was classified in Category 1 (cardiovascular system). As a result of examination by adding new information, the classification results were changed from the previous classification. [Evidence Data] (1) In a human group in a community who ingested drinking water containing soluble barium, such as barium chloride, an increase in the incidence of hypertension, heart disease, or stroke was reported, and in another similar group, an increase in mortality due to cardiovascular disease and heart disease such as arteriosclerosis was observed (ATSDR (2007)). (2) It was reported that the incidence of hypertension increased in workers exposed to soluble barium of an average of 1.07 mg/m3 by mixing and grinding various grades of barium in a mineral processing facility (CICAD 33 (2001)). (3) In tests by oral administration of sodium hypochlorite to animals dosed by drinking water, only a decrease in body weight gain, presumably due to low water intake, was observed even when rats and mice were dosed for 90 days and 2 years (EURAR (2007), SIAR (2006)). (4) In a test by dermal application of an aqueous solution of sodium hypochlorite to guinea pigs for 51 weeks (twice a week), no treatment-related effects were observed (AICIS (previous NICNAS) IMAP (2015), EURAR (2007), SIAR (2006)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
|