NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	13494-80-9
Chemical Name	Tellurium
Substance ID	m-nite-13494-80-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	There is the information that it is combustible (ICSC (2000)), but the classification is not possible due to no data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 340 deg C (ICSC (2000)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Because there is the information that the experimental manufacturing method from tetradymite is done in water (Encyclopedia Chimica (Kyoritsu Shuppan Co., Ltd.) (1962)), it is estimated that it does not react vigorously with water.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	It is an inorganic substance not containing oxygen or halogen.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic substance.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on a report of an LD50 value of > 5,000 mg/kg (DFGOT Vol.22 (2006)) for rats, it was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a report of an LC50 value (4 hours) of > 2.42 mg/m3 (DFGOT Vol.22 (2006)) for rats, however, it is not possible to specify a category with this value alone. Based on information from DFGOT Vol.22 (2006) with higher priority which was obtained in this survey, the text was revised.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. There is no information on skin irritation among the information sources in List 1 or List 2. Since the information described in the previous classification was from the information source in List 3 and was not specific information, it was not adopted.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. There is no information on eye irritation among the information sources in List 1 or List 2. Since information described in the previous classification was from the information source in List 3 and was not specific information, it was not adopted.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	For this substance and insoluble tellurium compounds, classification was not possible due to lack of data. Besides, for information on soluble tellurium compounds, please refer to this hazard class of tellurium tetrachloride (CAS RN: 10026-07-0).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 1B,	Danger	H360 H362	P308+P313 P201 P202 P260 P263 P264 P270 P280 P405 P501	There is a report that increased incidence of hydrocephalus was observed in a test where metallic tellurium was administered by diet (165-220 mg/kg/day) to pregnant rats on organogenesis period (gestational day 6-15) (DFGOT vol. 22 (2006), PATTY (6th, 2012)), and a report that increased incidence of fetal encephalopathy was observed when metallic tellurium was administered by diet to pregnant rats during the gestation period (ACGIH (7th, 2001)), and there is a description that in a test where pregnant rats were dosed with tellurium dioxide by feeding during gestational days 15-19 (13-65 mg/kg/day), increased incidence of hydrocephalus, edema, exophthalmos was observed (DFGOT vol. 22 (2006)). Furthermore, there is a report that as a result of exposure to tellurium via breast milk until the postnatal day 0-28 in neonatal rats, Schwann cell and myelin degeneration in the sciatic nerves, and hypomyelination and myelin degeneration of the optic nerve in the central nervous system were observed (PATTY (6th, 2012)). From the above, since as a result of oral administration to pregnant animals, at doses where maternal toxicity is unknown, induction of external malformations such as hydrocephalus, and occurrence of encephalopathy were observed in fetuses, and myelination inhibition in the peripheral nerves and optic nerve were observed by exposure to this substance via breast milk in the neonatal period, multiple findings that oral exposure to this substance in the embryonic or neonatal period caused developmental disorders of the nervous system in the next generation were shown. Therefore, it was judged that the classification in Category 1B was appropriate for this hazard class, and "additional category for effects on or via lactation" was added.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	This substance is irritating to the respiratory tract (HSDB (Access on September 2015)). For humans, in worker exposure cases (unknown route), anorexia, nausea, a metallic taste, garlic-like odor in the breath and sweat, drowsiness were reported (ACGIH (7th, 2001), DFGOT Vol.22 (2006)). Other than these symptoms, there is also a description of liver injury (HSDB (Access on September 2015)), however, the details were unknown. As for experimental animals, there are descriptions that prominent features of acute effects of this substance were pneumonia, hemolytic anemia, acute oral or non-oral tellurium intoxication resulting in restlessness, tremor, hyporeflexia, paralysis, convulsions, drowsiness, coma, and hematuria (ACGIH (7th, 2001), DFGOT Vol.22 (2006)), however, since the doses were unknown, it was not possible to decide a category. From the above, this substance is irritating to the respiratory tract, and has narcotic effects, it was classified in Category 3 (respiratory tract irritation, narcotic effects). Besides, in the previous classification, it was classified in Category 2 (peripheral nervous system) based on a description in PATTY, but since this finding was not single exposure data, it was not adopted.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. In humans, in an occupational exposure case of exposure to tellurium fume (tellurium and tellurium oxide) at 0.01-0.1 mg/m3 for 22 months in a steel plant, garlic-like odor in the breath and sweat, dryness of the mouth, metallic taste, sleepiness were observed, and transient nausea was seen in workers close to the source of tellurium exposure (PATTY (6th, 2012), DFGOT Vol.22 (2006), ACGIH (7th, 2001)). As for experimental animals, in multiple tests with weanling rats dosed by feeding for 18 days to 6 months, effects on the nervous system (hindlimb paralysis caused by demyelination of the sciatic nerve, neural edema, Schwann cell degeneration, remyelination) were reported, and in a 30-day feeding tests with adult rats, garlic-like odor, blue-grey discolorations of the skin, restricted movement without signs of paralysis, death, and in the nerve fibers, myelin changes, segmental demyelination and remyelination were reported (DFGOT vol. 22 (2006)). These were seen in a range exceeding Category 2. Besides, there is a report that in a 13-15-week inhalation toxicity test with rats, at 10-100 mg/m3 (2 hours/day) (converted guidance value: 0.0033-0.033 mg/L) which was in a range of Category 1 or 2, decreased body weight, drowsiness, irritation of the respiratory tract, loss of fur, hemolysis (reduction in the number of erythrocytes and hemoglobin content, increase in bilirubin in the urine) etc. were observed, and half of the animals exposed at 100 mg/m3 died (other details were unknown) (DFGOT vol. 22 (2006)). However, since the original article was an abstract, and reliability could not be confirmed, it was not used for classification. From the above, no findings which should be adopted as the target organ were observed in humans. Effects on the nervous system were observed in experimental animals, however, the doses of these exceeded the range of Category 2. Therefore, it was classified as "Classification not possible" due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information