NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	13517-24-3
Chemical Name	Sodium metasilicate nonahydrate
Substance ID	m-nite-13517-24-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified	- -	-	-	From the information that it is "Not combustible" (PIM 500 (1997)); (ICSC (J) (2004)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified	- -	-	-	From the information that it is "Not combustible" (PIM 500 (1997)); (ICSC (J) (2004)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Not classified	- -	-	-	From the information that it is "Not combustible" (PIM 500 (1997)); (ICSC (J) (2004)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains a metal (Na) and a semimetal (Si), but it is conceivable that it does not react vigorously with water from data on the water solubility as "VERY SOLUBLE" (HSDB (2003)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Classification not possible	- -	-	-	An inorganic compound does not contain halogen but contains oxygen which is chemically bonded to elements other than carbon or hydrogen, but the classification is not possible due to no data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	The classification is not possible because a solid with a melting point of 55 degrees C or lower has no data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	From an LC50 value of an anhydrate for rats which was converted from 1152 to 1349 mg/kg into 2682 to 3140 mg/kg in molecular weight conversion (SIDS (2004)), it was classified as "Not classified" in JIS Classification (Category 5 in UN GHS classification). Besides, refer to an anhydrate of this substance (CAS: 6834-92-0) and a pentahydrate of this substance (CAS: 10213-79-3) for health hazards.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	From erythema and edema accompanied by necrosis lasted until day 5 and a primary dermal irritation index (PDII) of 8 which was assessed as corrosive in a semi-occlusive test applied 0.5g this substance moistened by water to rabbit skin for 24 hours (OECD TG404, GLP) (SIDS (2004)), it was classified in Category 1. On the other hand, erythema and edema were not observed when the dry powder of this substance was applied (SIDS (2004)). Besides, the pH of a 1% solution is 12 to 13 at 20 degrees C (IUCLID (2000)). And an anhydrate is classified in R34 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	From "corrosive" as a result of an in vitro test applied to rabbit eyes (GLP compliance), pH 12 to 13 of a 1% solution at 20 degrees C (IUCLID (2000)), and "Category 1 (corrosive)" classification in skin corrosion/irritation, it was classified in Category 1.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	Lack of data. Besides, a negative result in an LLMA test (OECD TG429) on an anhydrate in mice, and contact urticaria in a human in a case study and formation of ulcer and wheal in the same human in a patch test (30 control subjects showed negatives) (SIDS (2004)) were reported. But details are unknown.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	On the basis that a chromosomal aberration test using mouse bone marrow cells after oral administration of an anhydrate resulted in a negative (in vivo somatic cell mutagenicity test) (SIDS (2004)), it was classified as "Not classified." Besides, a negative result on an anhydrate was reported in an Ames test as an in vitro test (SIDS (2004)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	Lack of data. Besides, it is reported that significant effects were not observed in a drinking water administration test on an anhydrate in rats shortened to 14 months from 24 months as planned due to high mortality in all groups (SIDS (2004)), and carcinogenicity was not observed in another 2-year exposure test (IUCLID (2000)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	Lack of data. Besides, no effects on parameters such as an implantation number, litter size, fertility index, numbers of live/dead fetuses, fetal body weights nor increased malformations of inner organs and the skeleton were reported in observations of fetuses at the end of pregnancy and neonates after deliveries in oral administration of an anhydrate during pregnancy including an organogenetic period to mice (SIDS (2004)). But there are no data on effects on sexual function and fertility in parent animals.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	Lethargy, increased breathing frequency, platycoria, and cramps in a single oral administration test in rat (doses: males 538 to 2000 mg/kg, females 910 to 2600 mg/kg) and signs including lethargy, no reaction to external stimuli, hanging eyelids, paralysis of hind limbs, clonic/tonic cramps, cyanosis, and respiratory paralysis in a single oral administration test in mice (doses: males 500 to 1921 mg/kg, females 500 to 1372 mg/kg) (both SIDS (2004)) were reported as data on an anhydrate. Because doses converted to a nonahydrate by molecular weight conversion of the above nervous signs range to doses of a range of Category 2 in Guidance values ("1252 mg/kg or higher" or "1164 mg/kg or higher" respectively), it was classified in Category 2 (nervous system).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	A 26-day diet administration test using this substance in rats reported no adverse effects except tooth pigmentation, hair loss, seborrhea, and loss of tonicity (SIDS (2004)), but it is commented that the test is not a toxicity test due to the unsuitable test system having insufficient test items (SIDS (2004)). Because the doses converted to a nonahydrate by molecular weight conversion from the reported data on an anhydrate, NOAEL of 227 to 237 mg/kg/day in a 3-month drinking water administration test in rats (SIDS (2004)), NOAEL of 792 mg/kg/day in a 2-year dirnking water administration test in rats (IUCLID (2000)), and NOAEL of 260 to 284 mg/kg/day in a 3-month drinking water administration test in mice (SIDS (2004)), exceeded the upper limit of Category 2 in Guidance values, it corresponds to "Not classified" in an oral route. But it was classified as "Classification not possible" due to no information in other routes.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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