NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	135186-78-6
Chemical Name	7-[(4,6-Dimethoxypyrimidin-2-yl)sulfanyl]-3-methylisobenzofuran-1(3H)-one; Pyriftalid
Substance ID	m-nite-135186-78-6_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)
Sample SDS by MHLW (External link)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rats: > 5,000 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008))	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rats: > 2,000 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008))	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LC50 for rats (4 hours): > 5.54 mg/L (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007))	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
2	Skin corrosion/irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 6) (GLP, 4-hour application, 7-day observation), slight erythema and edema were observed from 1 hour after the removal of patches but disappeared after 7 days (mean erythema score: 1.0, mean edema score: 0.39) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
3	Serious eye damage/eye irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in an eye irritation test with rabbits (n = 6) (GLP, 72-hour observation), conjunctival irritation was seen after 1 hour and later but disappeared within 48 hours (mean corneal opacity score for all the animals: 0, mean iritis score: 0, mean conjunctival redness score: 0.39, mean chemosis score: 0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
4	Skin sensitization	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in a maximization test with guinea pigs (n = 20) (GLP, intradermal administration: unknown concentration), a positive rate was 0% (0/20) at both 24, 48 hours after a challenge (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
5	Germ cell mutagenicity	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) to (6), it was classified as "Not classified." [Evidence Data] (1) In a micronucleus test with the bone marrow cells of mice and the hepatocytes of rats (GLP, single oral dose), negative results were obtained (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). (2) In an unscheduled DNA synthesis (UDS) test (GLP), which was carried out as an in vivo/in vitro test, negative results were obtained (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). (3) In a bacterial reverse mutation test (GLP), the substance was negative (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). (4) In a gene mutation test with the lymphoma-derived cultured cells of mice (GLP), the substance was negative (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). (5) In a chromosomal aberration test with the Chinese hamster ovary cells and human lymphocytes (GLP), the substance was negative (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). (6) In an unscheduled DNA synthesis test with the hepatocytes from rats (GLP), the substance was negative (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
6	Carcinogenicity	Not classified	- -	-	-	[Rationale for the Classification] There was no classification result by domestic and international organizations. However, based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) In a 2-year combined chronic toxicity/carcinogenicity study with rats (GLP, dosed by feeding), no incidence nor increase of tumors associated with the sample administration was observed at doses up to 3,000 ppm in males and up to 7,500 ppm in females. The carcinogenicity was not observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). (2) In an 18-month carcinogenicity study with mice (GLP, dosed by feeding), the incidence frequency of hepatocellular adenoma increased in females of the group dosed at or above 2,500 ppm (male/female: 337/325 mg/kg/day) compared to the control group, but since there was no statistically significant difference and no earlier onset was observed, it was not considered to be the effect of the sample administration. The carcinogenicity was not observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
7	Reproductive toxicity	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) to (3), it was classified as "Not classified." [Evidence Data] (1) It was reported that in a two-generation reproduction toxicity study with rats dosed by feeding (GLP), at 5,000 ppm, increases in absolute and relative weight of the liver and kidney, hypertrophy of the hepatocytes (centrilobular), hypertrophy of the follicular cells of the thyroid (P and F1 male/female), inhibition of body weight gain (P male/female), an increase in relative weight of the thyroid (P male), and basophilic changes of the tubules of the kidney (with tubular cast in males) (F1 male/female) were observed in parent animals; and increases in absolute/relative weight of the liver and hypertrophy of the hepatocytes (centrilobular) (F1 and F2 male/female) were observed in offspring, but no effect on reproductive ability was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). (2) It was reported that in a developmental toxicity study with rats dosed by gavage (GLP, days 6 to 15 of gestation), no teratogenicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). (3) It was reported that in a developmental toxicity study with rabbits dosed by gavage (GLP, days 7 to 19 of gestation), no teratogenicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
8	Specific target organ toxicity - Single exposure	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) to (4), in all of the oral, dermal, and/or inhalation routes, it was classified as "Not classified." [Evidence Data] (1) It was reported that in an acute oral toxicity test with rats, at 5,000 mg/kg (in the range corresponding to "Not classified"), no death nor appearance of symptoms was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)). (2) It was reported that in an acute oral toxicity test with mice, at 5,000 mg/kg (in the range corresponding to "Not classified"), no death nor appearance of symptoms was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)). (3) It was reported that in an acute dermal toxicity test with rats, at 2,000 mg/kg (within the range for Category 2), no death nor appearance of symptoms was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)). (4) It was reported that in an acute inhalation (dust, mist) exposure test with rats (4 hours), at 5.54 mg/L (in the range corresponding to "Not classified"), there was no death, and a mild decrease in the respiration rate, smudge around the eye, and blepharospasm were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Based on (5), histopathological changes were observed in the peripheral nerves in rats at and above the dose of Category 1, but in a long-term administration test with mice in (6), the same changes were not observed after the administration in super large amounts. Based on (1) to (4), no finding related to neurotoxicity was observed in tests with rats and dogs either, therefore, there was insufficient evidence for considering the nervous system as the target organ. Furthermore, since no target organ toxicity was observed within the dose range for Category 1 and Category 2, it was considered to be classified as "Not classified" in the oral route, however, classification was not possible since there was not sufficient information on toxicity available for classification in the other routes. [Evidence Data] (1) It was reported that in a 90-day oral toxicity test with rats dosed by feeding (GLP), at or above 3,000 ppm (242 mg/kg/day (male), 265 mg/kg/day (female), in the range corresponding to "Not classified"), effects on the liver, kidney, blood system, etc. were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)). (2) It was reported that in a 90-day subacute neurotoxicity test with rats dosed by feeding (GLP), no neurotoxicity was observed at doses up to the maximum dose of 15,000 ppm (1,140 mg/kg/day (male), 1,230 mg/kg/day (female), in the range corresponding to "Not classified") (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)). (3) It was reported that in a 90-day oral toxicity test with dogs dosed by feeding (GLP), at 1,000 ppm (37.1 mg/kg/day (male), 44.6 mg/kg/day (female), within the range for Category 2), increases in absolute/relative weight of the liver were observed in males, and at 30,000 ppm (1,130 mg/kg/day (male), 1,290 mg/kg/day (female), in the range corresponding to "Not classified"), an increase in weight of the liver was observed also in females, but no histopathological change was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)). (4) It was reported that in a 1-year chronic toxicity study with dogs dosed by feeding (GLP), at or above 6,000 ppm (176 mg/kg/day (male), 193 mg/kg/day (female), in the range corresponding to "Not classified"), effects on the blood, liver, and thyroid were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)). (5) It was reported that in a 2-year combined chronic toxicity/carcinogenicity study with rats dosed by feeding (GLP), at 100 ppm (4.31 mg/kg/day (male), 5.37 mg/kg/day (female), within the range for Category 1), demyelination of the sciatic nerve was observed in females; at 1,000 ppm (43.9 mg/kg/day (male), 54.3 mg/kg/day (female), within the range for Category 2), demyelination of the sciatic nerve, and minor effects on the liver (an increase in relative weight, an increase in GGT) were observed in males; and at 3,000 ppm (129 mg/kg/day (male), 163 mg/kg/day (female), in the range corresponding to "Not classified"), demyelination of the lumbar spinal nerve root, degeneration of the skeletal muscle, effects on the liver, blood system, etc. were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)). (6) It was reported that in an 18-month carcinogenicity study with mice dosed by feeding (GLP), at or above 2,500 ppm (337 mg/kg/day (male), 325 mg/kg/day (female), in the range corresponding to "Not classified"), effects on the liver, kidney, and blood (female only) were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	It was classified as "Not classified" from 72-hour ErC50 > 0.9 mg/L for algae (Raphidocelis subcapitata), 48-hour EC50 > 1.8 mg/L for crustacea (Daphnia magna), and 96-hour LC50 > 0.33 mg/L for fish (Cyprinus carpio) (all, limit test, Document for registration standards for agricultural chemicals set by the Minister of Environment to prevent harm to animals and plants in areas of public waters, 2013)).	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (BIOWIN) and 72-hour NOErC = 0.95 mg/L for algae (Raphidocelis subcapitata) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2008)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained (crustacea, fish), it is not rapidly degradable (BIOWIN), 48-hour EC50 is > 1.8 mg/L for crustacea (Daphnia magna), 96-hour LC50 is > 0.33 mg/L for fish (Cyprinus carpio) (both, limit test, Document for registration standards for agricultural chemicals set by the Minister of Environment to prevent harm to animals and plants in areas of public waters, 2013)), and it is not water-insoluble (water solubility = 1.8 mg/L, A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2008)) and it is estimated to be a low bioaccumulation (logKow = 2.6, A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2008)), therfore, it is classified as "Not classified." By drawing a comparison between the above results, it was classified in Category 2.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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