NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	13530-65-9
Chemical Name	Zinc chromate
Substance ID	m-nite-13530-65-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (ICSC (2012)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (ICSC (2012)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (2012)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Because the observation result of being insoluble in water (ICSC (2012)) was obtained, it is estimated that it does not react vigorously with water.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen (but not halogen). Because it is a chromate, it is estimated to be oxidizing, but the classification is not possible due to no data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, although there are no concrete test reports, etc., there are many reports describing that hexavalent chromium compounds were corrosive (EU-RAR (2005), DFGOT vol. 3 (1992), OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, although there are no concrete test reports, etc., there are many reports describing that hexavalent chromium compounds were corrosive (EU-RAR (2005), DFGOT vol. 3 (1992), OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	The Japan Society for Occupational Health (JSOH) classified chromium compounds in occupational sensitizers to the airway Group 2. Although this substance is not specified in this classification, there is a description in OEL Documentations (Japan Society For Occupational Health (JSOH), 1989) that hexavalent chromium compounds are more toxic than divalent and trivalent compounds. In addition, there is a description that chromium compounds caused asthma (ATSDR (2012), EU-RAR (2005)). From the above, it was classified in Category 1.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Chromium compounds including this substance were classified in occupational skin sensitizers Group 1 by Japan Society For Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2014)). Although this substance is not specified in this classification, there is a description that hexavalent chromium compounds are more toxic than divalent or trivalent compounds in the OEL Documentations (Japan Society For Occupational Health (JSOH), 1989). In addition, there were many reports of contact dermatitis in workers who handled this substance (DFGOT vol. 15 (2001)). Moreover, although it is not information limited to this substance, there is a description that hexavalent chromium compounds were sensitizing to the skin (EU-RAR (2005), ATSDR (2012), PATTY (6th, 2012)). From the above, it was classified in Category 1.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	There are no in vivo data. As for in vitro, it was positive in bacterial reverse mutation tests, a gene mutation test, a chromosomal aberration test and a sister chromatid exchange test with cultured mammalian cells (IARC 49 (1990)). This substance is water-insoluble and in vivo mutagenicity information on water-insoluble Cr (VI) compounds was not obtained. This substance is a water-insoluble hexavalent chromium compound and it was classified in Category 2 according to the classification of other water-insoluble hexavalent chromium compounds. The previous classification was changed.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	Since it was classified in Group 1 (as chromium (VI)) by IARC (IARC (1990)), as A1 (as chromium (VI) compound) by ACGIH (ACGIH (7th, 2001)), as K (as hexavalent chromium compound) by NTP (NTP RoC (2014)) and in Group 1 (as chromium compound (hexavalent)) by Japan Society For Occupational Health (JSOH) (Japan Society For Occupational Health (JSOH), 1989), it was classified in Category 1A. In addition, this substance is classified as "Carc. Cat. 2; R45" in EU DSD classification, and as "Carc. 1B H350" in EU CLP classification.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	There are no data on this substance. As for reproductive toxicity of chromium (VI), potassium dichromate (CAS: 7778-50-9) and potassium chromate (CAS: 7789-00-6), water-soluble substances, were classified in Category 1B. Because this substance is insoluble in water, it was hard to say that it caused obvious reproductive effects on experimental animals. Therefore, it was classified in Category 2. Besides, chromium and its compounds were classified in reproductive toxicants Group 3 (provisional) (correspond to Category 2) in Recommendation of Occupational Exposure Limits (2014) by Japan Society For Occupational Health (JSOH). However, because the classification of Recommendation of Occupational Exposure Limits was in a provisional period, it was not adopted.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, respiratory organs, cardiovascular system, blood system, liver, kidney)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	There are no data on this substance. There are reports that respiratory tract irritation, respiratory tract inflammation, nose and chest pain, cough, dyspnea, cyanosis and kidney damage were observed by human inhalation exposure to hexavalent chromium compounds, that vomiting, diarrhea, gastrointestinal tract bleeding, liver necrosis, and renal tubular necrosis in the kidney were observed by human oral exposure, and that severe respiratory, cardiovascular, gastrointestinal, hematological, hepatic, renal, and neurological effects were reported by an accidental or intentional human ingestion at high-doses (ACGIH (7th, 2001), CICAD 78 (2013), EHC 61 (1988), EU-RAR (2005), ATSDR (2012)). This substance is a hexavalent chromium compound, and it was considered possible to use the toxicity findings of hexavalent chromium compounds for classification of this substance. The findings on the gastrointestinal tract were not adopted because of local irritation. From the above, it was classified in Category 1 (central nervous system, respiratory organs, cardiovascular system, hemal system, liver, kidney). The previous classification was changed.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	In epidemiological studies in workers occupationally exposed (co-exposure with lead chromate at multiple plants) to this substance at chromium pigment manufacturing plants which were conducted in Norway, UK, USA and Germany, etc., although an increase in the incidence of pulmonary cancer is described in all reports, there was no description of non-neoplastic effects by chronic exposure (ACGIH (7th, 2001)). In addition, there were no reports of clear effects by repeated exposure to this substance in either humans or experimental animals. However, based on multiple reports that the incidence of pulmonary cancer was increased by exposure to this substance alone or co-exposure with lead chromate, "the lung" was considered a target organ. Additionally, in the hazard assessment of a series of hexavalent chromium compounds including this substance, irritation of the respiratory tract and eyes were observed in humans who were exposed occupationally to hexavalent chromium compounds, as a result, it may cause ulcer/perforations in the nasal septum (CICAD 78 (2013)). Based on the above descriptions, this substance was classified in Category 1 (respiratory organs) just like other hexavalent chromium compounds.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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