Item | Information |
---|---|
CAS RN | 13718-26-8 |
Chemical Name | Sodium metavanadate |
Substance ID | m-nite-13718-26-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified |
- |
- | - | Not combustible (ATSDR DRAFT (2009)) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Not combustible (ATSDR DRAFT (2009)) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | Not combustible (ATSDR DRAFT (2009)) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Although it contains a metal (V), its water solubility is 21 g/100 g (25 degC) (Lide (88th, 2008)) and it is considered that the substance doesn't react strongly with water. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | This substance is an inorganic compound containing oxygen which is chemically bonded to the element other than carbon or hydrogen. However, due to lack of additional data, classification is not possible. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Inorganic compound | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
Based on the rat LD50 values of 98 mg/kg (CICADs 29 (2001)) and 212 mg/kg (DFGMAK-Doc.25 (2009)), the substance was classified into Category 3. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | The rat LC50 values of 4.98 mg/L (male) and 3.73 mg/L (female) was documented (DFGMAK-Doc.25 (2009)). Because of the uncertainty of the exposure time, the classification was not possible. Based on the state of solid (GHS definition), it was presumed that the tests were carried out with dust, and the criterion values for dust/mist were adapted. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
In the rabbit test, 20% solution of test substance caused irritation (EHC 81 (1998)). In the human case, 10% solution caused primary skin irritation (NIOSH Publications 77 - 222 (1977)). Based on these documents, the substance was classified as Category 2. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Insufficient data were available. In the case report of workers exposed to vanadium compound, patch tests to nine workers who presented dry dermatitis revealed one positive result, thus it was suggested that dry dermatitis was allergic reaction (DFGMAK-Doc. Vol. 25 (2009), original literature: SJOEBERG, S.-G. Vanadium pent oxide dust (1950)). Five of 125 workers with contact dermatitis by cement revealed a positive reaction to the substance in patch tests (EHC 81 (1988), original literature: Schweizerische Medizinische Wochenschrift NI'. 32 (1968)). However, neither report has clear mention that this substance is a skin sensitizer. Furthermore, none of the 17 workers that were exposed to dust containing vanadium, while cleaning boilers in oil power plant revealed positive reactions in patch tests (DFGMAK-Doc. Vol. 25 (2009), original literature: British Journal of Industrial Medicine (1980)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Although there was a positive result in the dominant lethal test (in vivo inheritable mutagenicity test in germ cell) in mice administered test substance by drinking water, the test did not meet standard protocol, and insufficient methods were used in the test such as no positive controls were employed and the examinations of female mice were conducted on the 10th day after mating. Therefore, it was concluded that there was a considerable limitation for utilization of this negative data (DFGMAK-Doc. Vol. 25 (2009)). No other in vivo test data are found. Accordingly, it was classified as "Classification not possible". As relevant information, as for in vitro tests, there are negative results in the Ames test (NTP DB (Access on May 2010)), positive results in the chromosomal aberration test and the micronucleus test using human lymphocytes (CICADs 29 (2001)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
In the feeding study in female rats during pregnancy and lactation periods (through day 21 postpartum), decreased survival of pups (PATTY, 5th (2001), ATSDR DRAFT (2009)), decreased maternal body weight gain and decreased food consumption as maternal toxicity were observed (ATSDR DRAFT (2009)). In the oral study in rats administered from 60 days before mating for males and during mating and pregnancy/organogenetic periods for females, there was no influence in fertility and reproductive functions of parents, and there wasn't maternal toxicity either, but, significantly lower body weight and body length were observed in both sex of pups until 21th day after birth (Japan Society For Occupational Health (JSOH), Recommendations for allowable concentrations, (2003), CICADs 29 (2001)). In an oral administration study via drinking water to male mice from 64 days before mating, a decrease in spermatid/spermatozoa count and in conception rate were observed in the high dose group (ACGIH (2009), CICADs 29 (2001)). There was some conclusion that there was no evidence of the direct reproduction/developmental toxicity of this substance, considering its maternal toxicity (CICADs 29 (2001)). However, the toxic effects cannot be denied. Therefore, the substance was classified as Category 2. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system, nervous system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
None of the data limited to this substance were available. In humans, however, as remarkable symptoms in the acute occupational exposure to the dust of the mixture consisting of this substance, vanadium pentaoxide, and ammonium metavanadate etc., severe neurosis and disorders of nervous system containing tremor of fingers and hands were reported (PATTY, 5th (2001)). It was also reported about the effects of acute occupational exposure to vanadium as follows: rhinitis with a sneezing or coughing and burning sensation in the throat as mild symptoms, and irritation of the upper respiratory tract and bronchitis with expiratory dyspnea and bronchospasm as moderate symptoms, and bronchitis and bronchopneumonia as severe symptoms (PATTY, 5th (2001)). Furthermore, in the animal experiments, toxic signs reflecting the effect on nerve system such as reduced motility, torpor, paralysis of hind legs and decreased sensitivity to pain, etc. were reported as common symptoms in rats exposed to vanadium compounds (DFGMAK-Doc. 25 (2009)). Based on the information, the substance was classified as Category 1 (nervous system, respiratory organs). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
No human information limited to the substance was available. It was reported, however, that workers who were occupationally exposed to dust mixtures of the substance and vanadium pentaoxide for several months or years caused various signs such as conjunctivitis, rhinitis, irritation of the mucous membrane of the respiratory tract, coughing with hemorrhage, dyspnea, convulsive bronchitis and chronic bronchitis, etc. (DFGMAK-Doc. 4 (1992)), and was reported, in numerous reports, that workers exposed to vanadium dusts occupationally revealed the symptoms as follows: bronchitis, bronchospasm, persistent cough, irritating symptoms of nasal mucosa, wheezing, rales, coarse crackles, greenish tongue, and dyspnea or palpitation were added at higher concentrations. In addition, the risk of occurrence of pulmonary emphysema was pointed out (Japan Society for Occupational Health (JSOH), Recommendations for allowable concentrations, vol. 45 (2003)). Thus, the substance was classified as Category 1 (respiratory system). Besides, regarding the toxicity studies in experimental animals, hypertrophy and hyperplasia of white pulp in spleen were observed in rats exposed to this substance via drinking water for three months, while decreases in hemoglobin concentration and hematocrit value and increases in reticulocyte were observed in another 10-week drinking study with rats. Both were inconsistent findings, but it was described the cause of contradicting results were unknown (ATSDR (2012)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
Classified into Category 2 from its 48h-LC50 = 2.3 mg/L for crustacea (Daphnia magna) (AQUIRE, 2011). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
Classified into Category 2 since its acute toxicity is Category 2 and adequate data on rapid degradation are not available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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