Item | Information |
---|---|
CAS RN | 138-22-7 |
Chemical Name | n-Butyl lactate |
Substance ID | m-nite-138-22-7_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P210 P280 P403 P501 |
Classified into Category 4 since flash point is 71 degC (NFPA (13th, 2006)). |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Auto-ignition point is 382 degC (NFPA (12th, 1997)). |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance contains oxygen (but not fluorine or chlorine) in the molecule which is chemically bonded only to carbon or hydrogen. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | A LD50 value of >2000 mg/kg for rats (PATTY (5th, 2001)) corresponds to "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification). |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. As relevant information, LD50 values are >5000 mg/kg for rabbits and >5000 mg/kg for rats (RTECS, 2008). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | A LC50 (4h) value of >5.14 mg/L for rats (PATTY (5th, 2001)) corresponds to "Not classified". Since the saturated vapour pressure concentration for the substance was 3.20 mg/L and the test was considered to be conducted for mists, the classification criteria for dust and mist was adopted. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. As relevant information, there is a result of "moderate irritation" after application to the skin of rabbits (RTECS (2005)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | There is a report that complaints of irritation of the conjunctiva were not confirmed by examination (ACGIH (7th, 2001)). Animal test data are not available. Based on these information, classification was not possible due to lack of data. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | No data available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335 H336 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
There is a report that prolonged exposures of humans resulted in irritation of the pharyngeal and laryngeal mucosa, with coughing, headache and sleepiness (ACGIH (7th, 2001)). A second report states: "Symptoms; irritation nose and throat, drowsiness, headache, central nervous system depression. Target Organs; respiratory system, central nervous system" (NIOSH Pocket Guide to Chemical Hazards (2005)). Based on this information, the substance was classified into Category 3 (respiratory tract irritation, narcotic effects). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | There is a report that occupational exposures results in irritation of the pharyngeal and laryngeal mucosa, with coughing and some workers complained of sleepiness and headache after work (ACGIH (7th, 2001)). This information indicate that the substance may possible cause damage to the respiratory system and nervous system. Classification was not possible due to lack of sufficient data. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
Classified into Category 3 from its 96h-LC50 = 75 mg/L for fish (Zebrafish) (AQUIRE, 2011). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Classified into Not classified since mean of 28d-BOD degradation rate tested by OECD TG301D (Closed Bottle Method) is 63% and the lactate is judged to be easily degradable from test results of other lactates (Bowmer et al, 1998), and low bioaccumulative potential is estimated (log Kow = 0.8 (PHYSPROP Database, 2009)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
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