NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	139920-32-4
Chemical Name	(RS)-2-Cyano-N-[(R)-1-(2,4-dichlorophenyl)ethyl]-3,3-dimethylbutyramide [diclocymet]
Substance ID	m-nite-139920-32-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)
Sample SDS by MHLW (External link)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	Due to no data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Classification not possible	- -	-	-	Due to no data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Due to no data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	It is an organic compound which does not contain fluorine but contains oxygen and chlorine and the oxygen and the chlorine are not chemically bonded to the elements other than carbon or hydrogen.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an organic compound that does not contain bivalent -O-O- structure in the molecule.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No established test method suitable for solid substances.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	From a reported LD50 value of > 5,000 mg/kg (males, females) for rats (Pesticide abstract (2008); Pesticide evaluation report, Food Safety Commission of Japan (2008); Japan Crop Protection Association: Pesticide safety information (Access on November 2015)), it was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	From a reported LD50 value of > 2,000 mg/kg (males, females) for rats (Pesticide abstract (2008); Pesticide evaluation report, Food Safety Commission of Japan (2008); Japan Crop Protection Association: Pesticide safety information (Access on November 2015)), it was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, an LC50 value (4 hours) of > 1.18 mg/L (males, females) for rats was reported (Pesticide abstract (2008); Pesticide evaluation report, Food Safety Commission of Japan (2008); Japan Crop Protection Association: Pesticide safety information (Access on November 2015)), but the category cannot be determined only by this data. Because a test substance is a solid, a reference value of dust was applied.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	It is reported that in a skin irritation test using rabbits, local reactions such as erythema and edema were not observed after application of this substance, and a primary irritation index on the Draize criteria was 0 (Pesticide abstract (2007); Pesticide evaluation report, Food Safety Commission of Japan (2008)). From the above, the substance was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It is reported that in a primary eye irritation test using rabbits, this substance was slightly irritating because conjunctival erythema and edema, corneal opacity, and iris congestion were observed after application of 100 mg the substance but resolved after 72 hours. (Pesticide abstract (2007); Pesticide evaluation report, Food Safety Commission of Japan (2008)) From the above, the substance was classified in Category 2B.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Not classified	- -	-	-	It is reported that in a maximization test using guinea pigs, this substance was not sensitizing because sensitizing reaction by the substance was not observed after induction and challenge (Pesticide abstract (2007); Pesticide evaluation report, Food Safety Commission of Japan (2008)). Because the above test is a GLP compliance test corresponding to OECD TG406, the substance was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	As for in vivo, a micronucleus test in mouse bone marrow cells after oral administration was negative (Pesticide abstract (2008)). As for in vitro, a bacterial reverse mutation test and a chromosomal aberration test in cultured mammalian cells were negative (Pesticide abstract (2008); Japan Crop Protection Association: Pesticide safety information (Access on November 2015); Food sanitation research, Vol.54 No.1 (2004)). Therefore, the substance was classified as "Classification not possible" in accordance with Guidance.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	In a carcinogenicity test in diet administration of this substance for 2 years in rats, or 1.5 years in mice, in rats, tumor lesions related to administration of test substance were not observed at the doses up to 2,000 ppm where weight gain reduction tendency and high liver weight were found in males and females (Pesticide abstract (2008); Food Safety Commission of Japan (2008)). On the other hand, in mice, increased hepatocellular adenoma was observed in males at 50 ppm or higher (Pesticide abstract (2008); Pesticide evaluation report, Food Safety Commission of Japan (2008)). Although an incidence of hepatocellular adenoma increased in male mice at 50 ppm or higher, it is difficult to consider that a mechanism of tumor occurrence is through genotoxicity, taking into account negatives in all genotoxicity tests and test results on a mechanism of benign liver tumors. Therefore, Food Safety Commission of Japan concluded that a threshold could be set in an assessment of this substance (Pesticide evaluation report, Food Safety Commission of Japan (2008)). As above, an increase of liver tumor was limited to a benign liver tumor in mice, and there is no evidence of carcinogenicity in rats. Moreover, there is no carcinogenicity classification result by the international organization. Therefore, the substance was classified as "Classification not possible" due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Not classified	- -	-	-	In a two-generation breeding toxicity test using rats in diet administration, effects on fertility were not observed in parent animals at the doses up to 2,000 ppm where effects on the liver (increased liver weight, centrilobular hypertrophy of hepatocytes) were found in F0, F1 parent animals. However, pups of both F1 and F2 generations showed weight gain reduction during a late nursing period at 200 ppm or higher (Pesticide abstract (2008); Pesticide evaluation report, Food Safety Commission of Japan (2008)). On the other hand, in a teratogenicity test in pregnant rats or rabbits in gavage administration during an organogenetic period, maternal animals of both species showed weight gain reduction after administration at doses of 1,000 mg/kg/day for rats and 300 mg/kg/day for rabbits. However, fetuses did not show abnormality related to administration of test substance (Pesticide abstract (2008); Pesticide evaluation report, Food Safety Commission of Japan (2008)). From the above, except slight growth suppression found in offspring during a nursing period (not used as a rationale for the classification due to slight effects) at the doses where general toxicity effects occurred in parent animals in the two-generation breeding toxicity test in rats, there are no findings showing reproductive/developmental toxicity for this substance. Therefore, it was classified as "Not classified" in this hazard class.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Not classified	- -	-	-	There are no human data. As for experimental animals, only decreased spontaneous motility in rats and mice in oral administration (a dose above Category 2) and decreased reaction to external stimuli in rats in inhalation exposure (a dose corresponding to Category 1) were observed as findings. (Pesticide abstract (2008); Pesticide evaluation report, Food Safety Commission of Japan (2008)) However, because an abnormality in signs and necropsy findings was not observed in any test even after administration up to the limit dose (or maximum possible concentration), the substance was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver)	Danger	H372	P260 P264 P270 P314 P501	In a 78-week diet administration toxicity test using mice, effects on the liver (increases of mass, enlarged and discolored regions in the liver, increased eosinophilic variant foci of hepatocytes) were observed at 50 to 500 ppm within a range of Category 1 (males: 8.4 to 86 mg/kg/day, females: 9.9 to 108 mg/kg/day). Moreover, in a 104-week diet administration toxicity test using rats, effects on the liver (centrilobular hypertrophy of hepatocytes) were found at 500 ppm within a range of Category 2 (males: 26.0 mg/kg/day, females: 33.9 mg/kg/day). (Pesticide abstract (2008); Pesticide evaluation report, Food Safety Commission of Japan (2008)) Therefore, the substance was classified in Category 1 (liver).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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