Item | Information |
---|---|
CAS RN | 140-11-4 |
Chemical Name | Benzyl acetate |
Substance ID | m-nite-140-11-4_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P210 P280 P403 P501 |
It was classified in Category 4 from a flash point of 90 deg C (closed cup) (HSDB (Access on September 2013)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 460 deg C (HSDB (Access on September 2013)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" (Category 5 in UN GHS classification) based on LD50 values for rats of 2,490 mg/kg (ACGIH (7th, 2001), PATTY (6th, 2012)) and 3,690 mg/kg (ACGIH (7th, 2001)). Besides, data in PATTY (6th, 2012) obtained in this investigation were added, and the classification was changed from Category 5 to "Not classified" according to the Classification JIS. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" based on an LD50 value of > 5,000 mg/kg for rabbits (PATTY (6th, 2012), IUCLID (2000)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
It was classified in Category 2 because it is described that it is irritating to the skin, eye, and respiratory tract (HSDB (Access on September 2013)), and it was moderately irritating in rabbits and humans in a GLP test according to the EC guideline (IUCLID (2000)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
It is described that it causes irritation to the eye (IARC (1986)), and it is irritating to the eye, and blepharospasm was observed in an eye irritation test with rabbits (HSDB (Access on September 2013)). Because there are no descriptions of reversibility, it was classified in Category 2 based on the above information. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | It is described in ACGIH (7th, 2001) that no reaction was observed at an 8% concentration of this substance in a sensitization test in volunteers, and it is described that it was negative in a Buehler test and a maximization test with guinea pigs and negative in a patch test in humans (IUCLID (2000)), but there is a description that sufficient data on sensitization were not available (ACGIH (7th, 2001)). Therefore, it was classified as "Classification not possible." | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in all of micronucleus tests with bone marrow cells and peripheral blood erythrocytes of mice (IARC (1999), JECFA TRS 909 (2002), NTP DB (Access on June 2013), IUCLID (2000)), a chromosomal aberration test with mouse bone marrow cells (IARC (1999), JECFA TRS 909 (2002), NTP DB (Access on June 2013)), a sister chromatid exchange test with mouse bone marrow cells (IARC (1999), JECFA TRS 909 (2002), NTP DB (Access on June 2013), IUCLID (2000)), an unscheduled DNA synthesis test with rat hepatocytes, and a DNA strand-break test with rat pancreas (IARC (1999), JECFA TRS 909 (2002)). As for in vitro, there are positive data in a mouse lymphoma test with cultured mammalian cells (IARC (1999), JECFA TRS 909 (2002), NTP DB (Access on June 2013)), but it was negative in a bacterial reverse mutation test (IARC (1999), ACGIH (7th, 2001), JECFA TRS 909 (2002), NTP DB (Access on June 2013), IUCLID (2000)) and a chromosomal aberration test with cultured mammalian cells (IARC (1999), JECFA TRS 909 (2002), NTP DB (Access on June 2013)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it is classified in A4 in ACGIH (1994) and Group 3 in IARC 71 (1999). The category was changed according to the GHS classification guidance for the Japanese government. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, as for developmental toxicity, in a developmental toxicity test with rats in the oral (gavage) route, maternal animals showed slightly reduced weight gain, and a decrease in fetal body weights was observed. No malformations were seen, but internal and skeletal variations were found, which were thought to be due to maternal toxicity and lower fetal body weights (JECFA FAS 868 (1996)). Furthermore, it is reported that in 13-week oral administration toxicity tests with rats or mice, no effects on the sperm and genetic organs were seen in males, and extension of the estrous cycle was observed in female mice, but this was associated with lower body weights (JECFA FAS 868 (1996), NTP TR431 (1993)), and it is described in PATTY (6th, 2012) that this substance was not considered to be a reproductive toxin because no compound-related effects on the genetic organs were found in subchronic toxicity tests with rats and mice. However, it was classified as "Classification not possible" because no sufficient tests on fertility effects were conducted. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs), Category 3 (narcotic effects) |
Danger Warning |
H370 H336 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
It was classified in Category 1 (respiratory organs), Category 3 (narcotic effects) because it is described that it produces respiratory tract irritation and narcotic effects in humans (NTP TR250 (1986), ACGIH (7th, 2001)), and lung hyperemia, pulmonary edema (ACGIH (7th, 2001)), and central nervous system depression (NTP TR431 (1993)) were observed in mice after exposure to vapour (1.3 mg/L) within the guidance value range for Category 1. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (kidney), Category 2 (nasal cavity) |
Danger Warning |
H372 H373 |
P260 P264 P270 P314 P501 |
It was classified in Category 1 (kidney) because it is described that continued inhalation exposure to this substance results in kidney damage in humans (NTP TR250 (1986)). On the other hand, as for experimental animals, no toxicity effects were seen even after exposure to the doses above the range for Category 2 in a 2-year diet administration test with rats (NTP TR431 (1993)), but it is described that nasal lesions (atrophy and degeneration of the olfactory epithelium, hyperplasia of the nasal submucosal glands, pigmentation of the nasal mucosal epithelium) were observed at the dose (35-40 mg/kg/day) within the guidance value range for Category 2 in a 2-year diet administration test with mice (NTP TR431 (1993)). It was classified in Category 2 (nasal cavity) from the viewpoint of assessing adverse effects while standing on the safe side. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified in Category 2 from 96-hour LC50 = 4 mg/L for fish (Oryzias latipes) (ECETOC TR91, 2003). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 3 |
- |
H412 | P273 P501 |
It was classified in Category 3 due to rapid degradability (a 28-day degradation rate by BOD = 95% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1989)), and 28-day NOEC = 0.92 mg/L for fish (Oryzias latipes) (ECETOC TR91, 2003). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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