Item | Information |
---|---|
CAS RN | 142459-58-3 |
Chemical Name | N-(4-Fluorophenyl)-N-isopropyl-2-{[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]oxy}acetamide; Flufenacet |
Substance ID | m-nite-142459-58-3_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | |
Sample SDS by MHLW (External link) | |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing fluorine and oxygen (but not chlorine) which are chemically bonded only to carbon or hydrogen. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
[Rationale for the Classification] It was classified in Category 4 from (1) - (3). [Evidence Data] (1) LD50 for rats (males): 683 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)) (2) LD50 for rats (males): 1,620 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)) (3) LD50 for rats (females): 589 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rats: > 2,000 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] The classification is not possible because effects are unknown at a dose near the upper limit for Category 4 in (1). [Reference Data, etc.] (1) LC50 for rats (4 hours): > 3.74 mg/L (mist) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 6) (GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation changes were seen in any animal (erythema/eschar score: 0/0/0/0/0/0, edema score: 0/0/0/0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in an eye irritation test with rabbits (n = 6) (GLP, 7-day observation), slight conjunctival redness in all the animals and slight chemosis in 5 were observed, but all of these disappeared within 7 days (corneal opacity score: 0/0/0/0/0/0, iritis score: 0/0/0/0/0/0, conjunctival redness score: 0.3/1/1/0.7/0.7/0.7, chemosis score: 0/0.3/0.3/0.3/0.3/0.3) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Category 1B |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
[Rationale for the Classification] It was classified in Category 1B from (1). [Evidence Data] (1) It is reported that in a maximization test with guinea pigs (n = 20) (GLP, intradermal administration: 5% solution), the positive rate was 60% (12/20), 45% (9/20) at 24, 48 hours after the removal of patches when challenged with a 25% solution, and the positive rate was 55% (11/20), 60% (12/20) at 24, 48 hours after the removal of patches when challenged with a 50% solution (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). [Reference Data, etc.] (2) A Buehler test with guinea pigs gave a negative result (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) to (4), it was classified as "Not classified." [Evidence Data] (1) In a micronucleus test using the bone marrow cells of mice (GLP, single intraperitoneal injection), negative results were reported (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (2) In a bacterial reverse mutation test (GLP), negative results were reported (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (3) In a gene mutation test using the cultured mammalian cells (CHL V79 cells) (GLP), negative results were reported (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (4) In a chromosomal aberration test using the cultured mammalian cells (CHO) (GLP), negative results were reported (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) to (3), it was classified as "Not classified." [Evidence Data] (1) As for the classification results by domestic and international organizations, the EPA classified this substance in NL (Not Likely to be Carcinogenic To Humans) (EPA Annual Cancer Report (2019): Classification in 1997). (2) In a two-year combined chronic toxicity/carcinogenicity study with rats dosed by feeding, no evidence of carcinogenicity was observed at doses up to 800 ppm (males/females: 39.0/49.8 mg/kg/day) at which apparent toxicity effects were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012), EPA Pesticides FACTS (1998)). (3) In a 20-month carcinogenicity study with mice dosed by feeding, no evidence of carcinogenicity was observed at doses up to 400 ppm (males/females: 62.2/77.2 mg/kg/day) at which apparent toxicity findings were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012), EPA Pesticides FACTS (1998)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) to (4), it was classified as "Not classified." [Evidence Data] (1) It was reported that in a two-generation reproduction toxicity study with rats dosed by feeding (GLP), no effect on fertility was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (2) It was reported that in a developmental toxicity study with rats dosed by gavage (GLP, days 6-15 of gestation), at 125 mg/kg/day, reduced body weight gain and a reduction in food consumption were observed in parental animals; and lower body weight, delayed ossification, and an increase in extra ribs were observed in pups, but no teratogenicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (3) It was reported that in a developmental toxicity study with rabbits dosed by gavage (GLP, days 6-18 of gestation), at 125 mg/kg/day, hepatocyte vacuolation (foamy), hypertrophy of hepatocytes, and an increase in frosted glass-like cytoplasm in hepatocytes were observed in parental animals; and an increase in skeletal variations (extra ribs, extra lumbar vertebral arches, and extra lumbar centrums) was observed in pups, but no teratogenicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (4) It was reported that in a developmental neurotoxicity test with rats dosed by feeding (GLP, from day 6 of gestation to day 11 of lactation, or days 6-24 of gestation), at 100 ppm, reduced body weight gain and a decrease in food consumption were observed in parental animals; and lower body weight, a delay in opening of the eyes, and a delay in preputial separation were observed in pups, but no developmental neurotoxicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
[Rationale for the Classification] Based on (1) to (4), the symptoms in the nervous system were observed after administration by the oral route, and in (1), effects were observed in the dose range for Category 1. Therefore, it was classified in Category 1 (nervous system). [Evidence Data] (1) It was reported that in an acute neurotoxicity test by oral administration to rats, ataxia, hypoactivity and stained fur around the reproductive organs (females) were observed at or above 75 mg/kg (within the range for Category 1); reductions in locomotor activity and locomotion performance (females) were observed at or above 150 mg/kg (within the range for Category 1); and ataxia, hypoactivity and reductions in locomotor activity and locomotion performance (males) were observed at or above 200 mg/kg (within the range for Category 1) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (2) It was reported that in an acute oral toxicity test with rats, hypoactivity, lacrimation, reddish tears, salivation, and staining of the natural cavities were observed in males and the LD50 was 683 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (3) It was reported that in an acute oral toxicity test with rats, ataxia, labored breathing, hypoactivity, stained fur, and increased secretion were observed and the LD50s were 1,620 mg/kg (males) and 589 mg/kg (females) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (4) It was reported that in an acute oral toxicity test with mice, hypoactivity, hyperreactivity, convulsions, unkempt fur, salivation, and lacrimation were observed and the LD50s were 1,330 mg/kg (males) and 1,760 mg/kg (females) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (nervous system, eye, blood system, liver, kidney) |
Warning |
H373 | P260 P314 P501 |
[Rationale for the Classification] The target organs were considered to be the blood, thyroid, liver, and kidney based on (1) to (6), the nervous system based on (3) and (4), and the eyes based on (5) and (6). The findings in the thyroid among these organs were considered to be due to physiological reactions associated with drug hypermetabolism in the liver, and the thyroid was excluded from the target organs. Adverse effects on the target organs were observed in the dose range for Category 2. Therefore, it was classified in Category 2 (nervous system, eyes, blood system, liver, kidney). [Evidence Data] (1) It was reported that in a 90-day oral toxicity test with rats dosed by feeding, at or above 400 ppm (24.3 mg/kg/day (males), at 28.8 mg/kg/day (females), within the range for Category 2), hematological effects (decreases in red blood cell count (RBC) and hemoglobin (Hb), a decrease in hematocrit (Ht) (males)), liver effects (hypertrophy of hepatocytes, an increase in smooth endoplasmic reticula, an increase in relative liver weight (males), single cell necrosis of hepatocytes (females)), and kidney effects (hyaline droplet deposition/degeneration in the proximal renal tubules (males), brown pigmentation of the proximal ureter (females), hyperplasia and foreign bodies of the renal pelvic epithelium (males)), and other effects were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (2) It was reported that in a 90-day oral toxicity test with dogs dosed by feeding, at 800 ppm (27.7 mg/kg/day (males), 28 mg/kg/day (females), within the range for Category 2) and 2,400 ppm (96.9 mg/kg/day (males), 93.2 mg/kg/day (females), within the range for Category 2), hematological effects (decreases in RBC, Hb, and Ht, an increase in platelet count (PLT)), thyroid effects (decreases in T3 and T4, hypertrophy of thyroid follicular cells (females)), liver effects (increases in absolute and relative liver weight, diffuse hypertrophy of hepatocytes, an increase in ALP), kidney effects (an increase in relative kidney weight, hyperplasia of the epithelium of the renal papilla (males), vacuolation of the cytoplasm in the renal collecting tubules (females), hyperplasia of the epithelium of the renal papilla (females)), brain effects (vacuolation of the cerebral cortex), and other effects were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (3) It was reported that in a 90-day repeated oral dose neurotoxicity test with rats dosed by feeding, an increase in the number of swollen axons in the cerebellum and the medulla oblongata and spinal cord was observed at or above 600 ppm (38.1 mg/kg/day (males), 42.6 mg/kg/day (females), within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (4) It was reported that in a one-year chronic toxicity study with dogs dosed by feeding, hematological effects (decreases in RBC, Hb, and Ht) were observed at 800 ppm (27.8 mg/kg/day (males), 26.8 mg/kg/day (females), within the range for Category 2) and liver effects (vacuolation of hepatocytes, hypertrophy of centrilobular hepatocytes, an increase in ALP), effects on the brain and nervous system (degeneration of axons in the spinal cord and the brain, abnormal brain waves, abnormal gait, abnormal posture, degeneration of axons in the sciatic nerve, hyporeactivity, an increase in muscle tone, and abnormal physiological nystagmus), and cardiac effects (an increase in relative cardiac weight, ventricular extrasystole, electrocardiogram abnormalities (notch in R wave/T wave, peaked T wave)), and other effects were observed at 1,600 ppm (62.2 mg/kg/day (males), 58.8 mg/kg/day (females), within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (5) It was reported that in a two-year combined chronic toxicity/carcinogenicity study with rats dosed by feeding, at 400 ppm (19.3 mg/kg/day (males), 24.4 mg/kg/day (females), within the range for Category 2) and 800 ppm (39 mg/kg/day (males), 49.8 mg/kg/day (females), within the range for Category 2), hematological effects (an increase in methemoglobin (MetHb), an increase in PLT (males)), liver effects (increases in absolute and relative weight, hypertrophy of hepatocytes, single cell necrosis of hepatocytes, hyperplasia of the intrahepatic bile duct (males)), kidney effects (mineral deposits in the renal pelvis, hyperplasia of the epithelium of the renal pelvis (males), an increase in nitrites in urine (males), an increase in pH of urine), effects on the eyes (mineral deposits in the sclera, cataract (females)), effects on the uterus (cystic hyperplasia of the endometrium), and other effects were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (6) It was reported that in a 20-month carcinogenicity study with mice dosed by feeding, an increase in cataract (males) was observed at or above 50 ppm (7.4 mg/kg/day (males), 9.4 mg/kg/day (females), within the range for Category 1); and an increase in MetHb and an increase in cataract (females) were observed at or above 200 ppm (30.4 mg/kg/day (males), 38.4 mg/kg/day (females), within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). [Reference Data, etc.] (7) In the results of various toxicity tests, the effects of the administration of flufenacet were observed mainly on the liver (hypertrophy of hepatocytes), the thyroid (hyperplasia of the follicular epithelium, etc.), the kidney (hyperplasia of the epithelium of the renal pelvis, etc.), the blood (an increase in MetHb, anemia), and the eyes (cataract: mice). In a subacute oral toxicity test (dogs), vacuolation of the cerebral cortex was observed in males and females in the group dosed at 2,400 ppm, and in a subacute neurotoxicity test (rats), swollen axons in the cerebellum and the medulla oblongata and spinal cord were observed in males and females in the group dosed at or above 600 ppm. Thus, neurotoxicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (8) With respect to the effects on the thyroid, an explanation was given that a decrease in thyroid hormone (T3/T4) due to the induction of UDP-glucuronosyltransferase in the liver activated the hypothalamus-anterior pituitary-thyroid axis, resulting in an increase in thyroid weight (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 72-hour ErC50 = 0.134 mg a.i./L for algae (Raphidocelis subcapitata) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012), Document for registration standards for agricultural chemicals set by the Minister of Environment to prevent harm to animals and plants in areas of public waters, 2013). (a.i.: active ingredient) | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (BIOWIN) and 72-hour NOErC = 0.000138 mg a.i./L for algae (Raphidocelis subcapitata) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012), Document for registration standards for agricultural chemicals set by the Minister of Environment to prevent harm to animals and plants in areas of public waters, 2013). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained (crustacea, fish), then it is classified in Category 3 due to being not rapidly degradable, and 48-hour EC50 = 30.3 mg/L for crustacea (Daphnia magna) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012), Document for registration standards for agricultural chemicals set by the Minister of Environment to prevent harm to animals and plants in areas of public waters, 2013). By drawing a comparison between the above results, it was classified in Category 1. (a.i.: active ingredient) |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
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