NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	143-08-8
Chemical Name	Nonan-1-ol
Substance ID	m-nite-143-08-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Since the flash point by NFPA(13th,2002) is 74degC, it was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified	- -	-	-	Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 260degC (Lide,88th,2007)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	The test method suitable for liquid substances is not established.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	The organic compound not including peroxy group in molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Although lower value of 3,560 mg/kg corresponded to the U.N. GHS acute toxicity Category 5 from LD50 value 3,560 mg/kg of the oral administration test employing a rat and 12,000 mg/kg (the MOE risk assessment / 6th volume (2008), HSDB (2006)) At home, it fell under unadopted category in Japan and was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Although LD50 value 2,960 mg/kg of the dermal administration test employing a rabbit (Patty (5th, 2001)) corresponded to the U.N. GHS acute toxicity Category 5, it fell under unadopted category in Japan and was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Saturated vapor pressure level at 25degCis 0.18 mg/L.. Since LC50 value of 2-hour inhalation exposure test employing mice is 5,500 mg/m3 (the 6th volume (2008) of the MOE Risk Assessment, Patty (5th, 2001)), the mist standard is applied. 4-hour equivalent LC50 value is 2.75 mg/L, and it was classified into Category 4 by applying the mist standard.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Although there is a description, "The irritation scores in undeluted liquid were 5.8/8.0 and they recovered in 10-14 days,"(HSDB (2006)) as a result of the 24 hour skin irritation test with rabbits classification is not possible, due to insufficiency of data. Incidentally, although there is a description, " Vaseline containing 2% of this substance did not cause irritation nor sensitivity in an volunteered experiment,"(MOE Risk Assessment, Vol. 6 (2008), Patty (5th, 2001)), it cannot be adopted, because it is not a datum with this substance undeluted.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	From the descriptions that "If 1-Nonanol eye irritation score is evaluated at the EU standard, it is thought to be eye irritant" (Patty (5th, 2001)) and that "The average irritation score of the non-diluted solution is 33.3/110 in 24-hours eye irritation test employing a rabbit and the symptom was slight actinic erythema, large amounts of copious discharge, and unrefined corneas" (HSDB (2006)), it was classified into Category 2A.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	Although it has been described that "vaseline which contains 2% of the substance did not show an irritation or sensitization to skin in a volunteer test" (the 6th volume of MOE Risk Assessment (2008)), or that "Nonanol (2% Petrolatum solution) is not a skin sensitizing substance to humans" (Patty (5th, 2001)), classification is not possible since they are inadequate for generalizing and there is no animal data in addition.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	It is described as follows in the 7 hour inhalation exposure test using female rats of 1-19 day pregnancy, "No effect related with the administration on mother rats' body weight, resorption, fetal animals' body weight, gender ratio, bone structure, internal organs, etc."(MOE Risk Assessment Vol. 6 (2008), Patty (5th, 2001)). In addition, there is a description as follows in the oral administration study using female rats of 1-15 day pregnancy, " Delayed growth of fetuses including embryos/fetal toxicity and delayed ossification has been reported" (Patty (5th, 2001)), and when the primary literature (Sov. J. Dev. Biol. 22 (1990)) was reviewed, symptoms were those of the intake result of some alcohol from Methanol to Decanol and the type of symptoms expressed with Nonanol was unknown, although there was a description as follows, " No teratogenicity is observed with fetuses but growth abnormalities of internal organs and bone structure are caused." Based on the above-mentioned, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	In the results of acute test against animals, from a description of "It has irritation to the skin, eye, and respiratory tract."(Patty (5th, 2001)), it was classified into Category 3 (Respiratory tract irritation). Although there is a description of "Weight reduction, increasing weakness, gum of eyelid, and sign of atrophy occur and, as a result of autopsy, bleeding of lungs, discoloration of liver, and gastroenteritis were observed"as a result of the oral administration test employing rats (HSDB (2006)), the discovered dose is unknown.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (eye)	Warning	H373	P260 P314 P501	In a 6-month inhalation exposure test with rabbits, it was reported that "changes were observed in the fine structure of the photoreceptor cells and the Muller fibers of the retina" (MOE Risk Assessment, vol. 6 (2008), HSDB (2006)). These were within the range of guidance values for Category 2, so it was classified as Category 2 (eye).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	"Ten out of the ten rats died by aspiration, and the deaths were caused immediately by respiratory arrest" (Patty (5th, 2001)). Moreover, although the kinematic viscosity at 20degC is calculated to be 14.13mm2/s (HSDB (2006)) and the viscosity at 40degC is expected to be 20.5mm2/s or less, the classification is not possible since the substance is not hydrocarbon. Although it falls into the U.N. GHS Category 2, the classification is not possible in Japan since it is categorized into "Not applicable."	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	It was classified into Category 2 from 72 hours EC50=2.2mg/L of the algae (Pseudokirchneriella subcapitata) (Environmental Agency eco-toxicity tests of chemicals (1999)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Since acute toxicity was Category 2 and there were no data about rapid degradability, it was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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