NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	148-24-3
Chemical Name	8-Quinolinol
Substance ID	m-nite-148-24-3_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 degC) substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on a LD50 value of 1200 mg/kg for rats (NTP TR276 (1985)), the substance was classified into Category 4.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	A LD50 value of 6 mg/animal (200 - 300 mg/kg; converted using body weight of 20 - 30 g) for mice (IARC 13 (1977)) corresponds to Category 3.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. As relevant information, a LC50 value was >1210 mg/m3/6h (>1800 mg/m3/4h) (RTECS (2008), the original literature: Journal of the American College of Toxicology.), classification was not possible since the value was in multiple categories.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on a result of "mild" in the Draize test where 500 mg was applied to the skin of rabbits for 24-hour (RTECS (2008); Journal of the American College of Toxicology), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] Based on (1), it was classified in Category 1. Besides, based on the new findings, the classification result was changed. [Evidence Data] (1) It was reported that, in an acute eye irritation/corrosion test (OECD TG 405, GLP, 20-day observation) with rabbits (n=3), no effects on the cornea were observed in two animals, while one animal showed effects on the cornea that persisted until day 20 (corneal opacity score: 1/0/0, iritis score: 0/0/0, conjunctival redness score: 1/1.3/1.3, chemosis score: 0.3/0.3/0.7) (ECHA RAC Opinion (2015), CLH Report (2014), AICIS IMAP (2019), REACH registration dossier (Accessed Dec. 2021)). [Reference Data, etc.] (2) In an eye irritation test with rabbits (n=8), no eye irritation was observed (corneal opacity score: 0/0/0/0/0/0/0/0, iritis score: 0/0/0/0/0/0/0/0, conjunctival redness score: 0/0/0/0/0/0/0/0, chemosis score: 0/0/0/0/0/0/0/0) (CLH Report (2014), AICIS IMAP (2019)). (3) It was reported that, in an eye irritation test with rabbits (n=6), 5 animals had ocular irritation, with corneal opacity in 4 of the animals (AICIS IMAP (2019)). (4) It was reported that, in an eye irritation test with rabbits, mild irritation that was reversible in 4 days was observed and the primary irritation index was 15.3 (full scale: 110) (AICIS IMAP (2019)). (5) In the ECHA, it was classified in Eye Dam. 1.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] Based on (1) to (3), it was classified in Category 1. Besides, based on the new findings, the classification result was changed. [Evidence Data] (1) It was reported that, in three patch tests using this substance in humans, the rates of positive response were 4.7%, 8%, and 6% (ECHA RAC Opinion (2015), CLH Report (2014), AICIS IMAP (2019)). (2) It was reported that, in a skin patch test series for the determination of contact eczema caused by drugs, hypersensitivity to this substance was observed only in three patients out of 450. In this report, this substance was considered to be a weak allergen (ECHA RAC Opinion (2015), CLH Report (2014), AICIS IMAP (2019)). (3) It was reported that, in the three skin sensitization studies in humans in (1), although all positive response rates were considered high frequency (>= 0.2% of general population, >= 1% of un-selected dermatitis patients, >= 2% of selected dermatitis patients), sub-categorization was considered not to be possible due to the lack of information with regards to grade of exposure, duration of studies and mode of application (ECHA RAC Opinion (2015)). [Reference Data, etc.] (4) In the ECHA, it was classified in Skin Sens. 1.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on negative results in an intraperitoneal injection mouse bone marrow micronucleus test and a chromosome aberration test (in vivo somatic cell mutagenicity tests) (NTP DB (access on Aug. 2009)), the substance was classified as "Not classified". As relevant information, a negative result is reported in intraperitoneal injection mouse bone marrow sister chromatid exchange (SCE) analysis (in vivo genotoxicity tests in somatic cells) (NTP DB (access on Aug. 2009). From in vitro tests, there are reports of a positive Ames test, a positive mouse lymphoma test and a positive CHO cell chromosomal aberration test (NTP DB (access on Aug. 2009)). The substance is an existing chemical substance for which mutagenicity was established under the provisions of Article 57-3 of the Industrial Safety and Health Law.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Not classified	- -	-	-	Based on the classification of "Group 3" in IARC (IARC suppl.7 (1987)), the substance was classified as "Not classified". As relevant information, in 2-year feeding tests with rats and mice, there was no evidence of carcinogenicity (NTP TR276 (1985)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] At high doses where general toxicity effects occurred in parent animals, adverse effects on sexual function, genetic organs, and fertility were observed as written in (1). At doses where transient symptoms occurred immediately after administration in maternal animals, an increased incidence of a malformation (omphalocele) was observed in fetuses as written in (2). It is classified in Category 2 by judging the category based on the Guidance, however, at the dose (15 mg/kg/day) where severe developmental effects were seen in (2), the toxicity which occurred in maternal animals were only slight symptoms (excitement, lethargy). Therefore, it was judged to be appropriate to classify it in Category 1B. Besides, the category was revised by the use of a new information source. [Evidence Data] (1) In a two-generation reproductive toxicity test with rats dosed by diet (OECD TG 416, GLP), in F0, F1 parent animals, general toxicity effects (reduced weight gain, decreased food consumption, pigmentation in the liver and so on) were found at or above 3,000 ppm (F0 mating: 291 mg/kg/day), a decrease in the number of estrus cycle and extended length of estrus cycle, decreases in weights of genetic organs (testis, seminal vesicle, prostate, ovary), a decrease in the number of live born pups per litter were observed at the highest dose, 8,000 ppm (before mating of F0: 855 mg/kg/day) as reproductive effects. In offspring, low values of body weight at weaning at 3,000 ppm and at postnatal days 7-21 at 8,000 ppm were found in both F1 and F2, and delayed sexual maturation (delays in preputial separation (males) and vagina opening (females)) was observed in F1 (Background Document to ECHA RAC Opinion (2015)). (2) In a developmental toxicity test (OECD TG 414, GLP) in which pregnant rabbits were dosed by gavage at up to 60 mg/kg/day on gestation days 6-28, symptoms of excitement and lethargy were found in maternal animals after doses of 15 mg/kg/day, and at the same dose or above, an increased incidence of omphalocele, that is a malformation, was observed in fetuses. Except for the above, an increased incidence of preorbital hemorrhage at 15 mg/kg/day and an increased incidence of retinal fold at 60 mg/kg/day were found in fetuses, however, these were regarded as findings within visceral variations (Background Document to ECHA RAC Opinion (2015)). [Reference Data, etc.] (3) In a developmental toxicity test (OECD TG 414, GLP) in which pregnant rats were dosed by gavage at up to 600 mg/kg/day on gestation days 6-19, symptoms (nervous system excitement, lethargy), reduced weight gain, decreased food consumption were found in maternal animals at or above 300 mg/kg/day as clear toxicity. In fetuses, only low values of fetal body weight, visceral variations (enlarged nasal cavity, unilateral hydronephrosis), and skeletal variations (supernumerary rib, delayed ossification) were observed at up to 600 mg/kg/day, and these were findings within slight effects which were not regarded as evidence of developmental effects (Background Document to ECHA RAC Opinion (2015)). (4) It was classified in Repr. 1B in EU CLP.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a report of 13-week feeding tests with rats and mice (NTP TR276 (1985)), no exposure related effects were observed in all examinations including histopathological examination except for decreases in body weight gain and food consumption at the highest dose level of 12,000 ppm (660 mg/kg/day) in rats or 6,000 ppm (774 - 888 mg/kg/day) in mice. Although the substance corresponds to "Not classified" with oral exposure since these levels exceed the guidance value range, classification was not possible due to lack of data with other exposure routes.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Classified into Category 1 from its 72h-EC50 = 0.52 mg/L for algae (Pseudokirchneriella subcapitata) ((Ministry of the Environment), 2004).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (Non-biodegradable, decomposition by BOD degradation rate: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1994)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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