Item | Information |
---|---|
CAS RN | 149-30-4 |
Chemical Name | 2-Mercaptobenzothiazole |
Substance ID | m-nite-149-30-4_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Classification not possible |
- |
- | - | It is combustible, but the classification is not possible due to no data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 628 deg C (ICSC(J) (2004)). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on the LD50 value of > 3,800 mg/kg (PATTY (6th, 2012)) for rats, this substance was classified as "Not classified" (Category 5 in UN GHS classification). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on the LD50 value of 7,940 mg/kg (PATTY (6th, 2012), BUA 237 (2000)) for rabbits, this substance was classified as "Not classified." | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a report that the LC50 value (4 hours) for rats is > 1,270 mg/m3 (gender unknown) (BUA 237 (2000)). However, classification is not possible because a category cannot be determined based on this value alone. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | No irritation was observed in a test using rabbits (PATTY (6th, 2012)) and in a human patch test (PATTY (6th, 2012)). Therefore, this substance was classified as "Not classified." | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | Since no irritation was observed in a study using rabbits (PATTY (6th, 2012)), this substance was classified as "Not classified." | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
A maximization test and Buehler test using the guinea pigs were positive (ECETOC (1999), PATTY (6th, 2012)), and a murine local lymph node assay was positive (ECETOC (1999)). Moreover, the occurrence of contact dermatitis and skin sensitization has also been reported in humans (ECETOC (1999), PATTY (6th, 2012)). From the above, this substance was classified in Category 1. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible," because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese Government. As for in vivo data, a mouse dominant lethal assay, a micronucleus assay and an unscheduled DNA synthesis assay using rat liver are negative (EPA RED (1994), PATTY (6th, 2012)). As for in vitro data, a bacterial reverse mutation test and a gene mutation test using mammalian cultured cells are negative, mouse lymphoma assays show positive and negative results, and a chromosomal aberration test and a sister chromatid exchange test are positive (EPA RED (1994), NTP TR332 (1988), PATTY (6th, 2012)). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Category 1B |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
IARC recently pre-announced that this substance has been classified in Group 2A, but details on humans etc. are unknown since the monograph itself is unpublished as of June 2016 (IARC 115 (in prep., Access in June 2016)). However, in experimental animals, in a carcinogenicity study using rats or mice given this substance by gavage administration for 2 years, as neoplastic changes showing dose-response relationships in rats, increases in pituitary gland adenomas (females), in the incidence of preputial gland adenomas or carcinomas (combined) (males), in the incidence of benign or malignant pheochromocytomas in the adrenal gland (combined) (males), etc. were observed; and in mice, an increase in the incidence of hepatocellular adenomas or carcinomas (combined) was observed in the low-dose female mice group (NTP TR332 (1988), EPA RED (1994)). As for classifications by other organizations, the EPA has previously classified this substance in Group C (possible human carcinogen: equivalent to Category 2) (EPA RED (1994)). As described above, in the experimental animals, positive results were obtained with two species. Therefore, this substance was classified in Category 1B for this hazard class, taking into account the IARC's pre-announced listing as well. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Not classified |
- |
- | - | In a 2-generation reproductive toxicity study using rats by oral administration (feeding), no effects on fertility were observed even at doses (695 to 783 mg/kg/day or above) where the effects of general toxicity (decreased weight gain, increased kidney weights, increased brown pigment in the kidneys, increased incidence of basophilic tubules, etc.) were observed in the parental animals (EPA RED (1994), PATTY (6th, 2012)). Also, in a combined repeated dose toxicity study with a reproduction/developmental toxicity screening test using rats, despite administration by gavage at up to 1,000 mg/kg, no reproductive/developmental effects were observed in either dams or fetuses (Safety Test (Ministry of Economy, Trade and Industry (METI), 2007)). On the other hand, it is described that in developmental toxicity studies using pregnant rats or pregnant rabbits by gavage administration during the organogenesis period (rats: Gestation days 6 to 15, rabbits: Gestation days 6 to 18), in the study using rabbits, no effects of administration were observed at up to 300 mg/kg/day in either dams or fetuses; and in the study using rats, increased post implantation loss was observed at 1,800 mg/kg/day where reduced body weight gain and food consumption were observed in the dams (EPA RED (1994)). However, it is reported that this finding is equivocal and is unlikely to be of toxicological significance (PATTY (6th, 2012)). From the above, there were no effects on fertility and pups even when administered at up to the limit dose, and clear developmental toxicity effects have not been reported from exposure to pregnant animals either. Therefore, this substance was classified as "Not classified" for this hazard class. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | There is no relevant information on humans. Besides, as for experimental animals, in a 13-week repeated dose toxicity study using rats by gavage administration, necrosis of the renal distal convoluted tubular epithelium is reported at 3,000 mg/kg/day, which is a dose exceeding Category 2 (PATTY (6th, 2012)). In addition, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using rats by gavage administration, effects on the liver (increased relative weights, centrilobular hepatocellular hypertrophy in the liver, high values in gamma-GTP) are reported at 1,000 mg/kg/day (converted guidance value: 466.7 mg/kg/day), which is a dose exceeding Category 2 (Safety Test (Ministry of Economy, Trade and Industry (METI), 2007)). Moreover, in a 2-year repeated dose toxicity study using rats by gavage administration, effects on the kidney (hyperplasia of the epithelium of the renal pelvis, focal hyperplasia of the tubular epithelium) are reported at 375 mg/kg/day or more, which is a dose exceeding Category 2; in a 13-week repeated dose toxicity study using mice by gavage administration, there are reports that lethargy was observed at 375 mg/kg/day (converted guidance value: 271 mg/kg/day), which is a dose above Category 2, and that effects on the nervous system (clonic seizure, lacrimation, salivation) were observed at 750 mg/kg/day (converted guidance value: 542 mg/kg/day) (NTP TR332 (1988)). As described above, effects on the liver, kidney, and nervous system were observed. However, they were observed at doses above the guidance value ranges of Category 2, so this substance was classified as "Classification not possible." |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
From 72-hour ErC50 = 0.5 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)), it was classified in Category 1. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (Non-biodegradable, a degradation rate by BOD: 2.5 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1977)), and 72-hour NOEC (r) = 0.066 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (Non-biodegradable, a degradation rate by BOD: 2.5 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1977)), and LC50 (unknown time) = 0.73 mg/L for fish (Oncorhynchus mykiss) (U.S.EPA: RED, 1994). It was classified in Category 1 from the above results. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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