Latest GHS Classification Results by the Japanese Government (edited by NITE)
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 156-60-5 |
| Chemical Name | trans-1,2-Dichloroethylene |
| Substance ID | m-nite-156-60-5_v1 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | To Guidance List |
| UN GHS document (External link) | To UN GHS document |
| FAQ（GHS classification results by the Japanese Government） | To FAQ |
| List of Information Sources (Excel file) | List of Information Sources |
| List of Definitions/Abbreviations | Definitions/Abbreviations |
| Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
| Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
| OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
|---|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 6 | Flammable liquids | Category 2 |
 Danger |
H225 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It was classified in Category 2 based on a flash point of 6 deg C (closed cup) and a boiling point of 48.7 deg C (HSDB (Access on June 2014)). Besides, it is classified in Class 3, PG II (UN1150) in UNRTDG. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule, but commonly distributed products contain a stabilizer. This substance is classified in Class 3, PG II (UN1150) in UNRTDG. Therefore, the stabilized one was classified in Type G. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 440 deg C (GESTIS (Access on June 2014)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to low-temperature-boiling liquids are not available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 17 | Desensitized explosives | - |
- |
- | - | - | - | - |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
|---|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 | P301+P312 P264 P270 P330 P501 |
There were 7 reports of LD50 values of 1,235 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)), 1,280 mg/kg (IRIS TR (2010)), 1,275 mg/kg (ACGIH (7th, 2001)), 7,900 mg/kg (male), 10,000 mg/kg (female) (ATSDR (1996)), 7,902 mg/kg (male), 9,939 mg/kg (female) (IRIS TR (2010)), 7,900 mg/kg (male), 9,900 mg/kg (female) (PATTY (6th, 2012)) and 1,235-10,000 mg/kg (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)) for rats. Although the category to which the larger number of values corresponded, was Category 4 or "Not classified" (3 cases each), it was classified in Category 4 to which the minimum LD50 value corresponded. Besides, because the remaining one was aggregated datum, it was not included in the number of applicable data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a report of an LD50 value of >5,000 mg/kg for rabbits (IRIS TR (2010), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005)), it was classified as "Not classified." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not classified |
- |
- | - | Based on a report of an LC50 value (4 hours) of 95,400 mg/m3 (=24,041 ppm) for rats (IRIS TR (2010)), it was classified as "Not classified." Besides, the LC50 value was lower than 90% of the saturated vapor concentration (435,526 ppm), the reference value in units of ppm was applied as a vapour without a mist. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
There are reports that mild to moderate erythema was observed in a skin irritation test by 24-hour occlusive application of a 0.5 mL of undiluted liquid of this substance to rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (1996), IRIS TR (2010)). In addition, there is a report that, after application of 5,000 mg/kg of this substance to the skin of rabbits, although severe skin irritation was observed, recovery was unknown (ATSDR (1996)). Moreover, in humans, there is a description that it was irritating to the skin (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). From the above result, it was classified in Category 2. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
There is a report that, in an eye irritation test in which 0.01 mL of the undiluted liquid of this substance was applied to the eyes of rabbits, with eyes washed 20 seconds after application, severe corneal opacity was observed in washed eyes, and although moderate iritis and conjunctivitis were observed whether or not washed, both 2 animals recovered 3 days after application (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (1996), IRIS TR (2010)). Moreover, in humans, there was a report of pain in the eyes with a burning sensation and mild inflammation by exposure to this substance (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). From the above results, it was classified in Category 2A. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test and a chromosomal aberration test with bone marrow cells and peripheral blood erythrocytes of mice, a sister chromatid exchange test with mice bone marrow cells (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), ATSDR (1996), IRIS TR (2010), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), NTP DB (Access on July 2014)). As for in vitro, although there were positive results in bacterial reverse mutation tests and a mammalian cell chromosome aberration test (heteroploidy), it was negative in other bacterial reverse mutation tests, and a chromosomal aberration test, a sister chromatid exchange test and an unscheduled DNA synthesis test with cultured mammalian cells (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), ATSDR (1996), IRIS TR (2010), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), NTP DB (Access on July 2014)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | There is a report that, in a teratogenicity test with rats by the inhalation route, decreased fetus body weight was observed at doses where maternal toxicities (decreased body weight, decreased feed consumption, coma, lethargy, salivation, alopecia) were observed (IRIS TR (2010), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Since the effects on fetuses were few, they were not adopted. Because effects on fertility were unknown due to lack of data, it was classified as "Classification not possible." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs, liver), Category 2 (heart), Category 3 (narcotic effects) |
 Danger Warning |
H370 H371 H336 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
In humans, it was irritating to the respiratory tract (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). In addition, by inhalation, there were reports of cough, sore throat, dizziness, nausea, drowsiness, weakness, vomiting, prostration, tremors, hallucinations, false recognition, depressed consciousness and elevated intracranial pressure, which suggested central nervous system depression, and abdominal pain might occur by oral ingestion. Moreover, this substance was used as an anesthetic and causes narcotic effects such as dizziness and nausea (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ACGIH (7th, 2001), ATSDR (1996)). As for experimental animals, narcotic effects were observed by inhalation exposure. In addition, there were reports on slight-severe fatty degeneration or fatty accumulation in hepatic lobules and Kupffer cells at 0.79 mg/L in rats, fibrous swelling and hyperemia of the cardiac muscle, disappearance of the striated pattern of the cardiac muscle at 11.90 mg/L, and severe pulmonary hyperemia, alveolar septal distention and pneumonic infiltration at 3.97 mg/L and 11.90 mg/L (whether the trans-isomer or not was unknown) (ACGIH (7th, 2001), ATSDR (1996), PATTY (6th, 2012)). There were reports of decreased activity, ataxia, loss of righting reflex, piloerection, hunched posture, depressed respiration, hyperemia of the mucosal surface of the stomach and small intestine at 1,000 mg/kg by the oral administration to rats or mice. In necropsy findings of rats, severe pulmonary capillary hyperemia, alveolar septal distention, fibrous swelling and hyperemia in the cardiac muscles were observed. In necropsy findings of mice, hyperemia of the mucosal surface of the stomach and small intestine was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ACGIH (7th, 2001), ATSDR (1996), PATTY (6th, 2012)). Besides, in the above findings on experimental animals, effects on the respiratory organs and the liver were observed within the guidance value range corresponding to Category 1, and effects on the heart were observed within the guidance value range corresponding to Category 2. From the above, it was classified in Category 1 (respiratory organs, liver), Category 2 (heart), Category 3 (narcotic effects). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In humans, there were no available data for classification. As for experimental animals, in a 90-day administration test with mice by drinking water, or in a 14-week administration test with rats by feeding, effects on the liver (increased weight, increased serum ALP), the blood system (a decrease in erythrocyte counts, hemoglobin, hematocrit value, and leukocyte counts), the immune system (decreased humoral immunity (only mice)) were observed at a high dose (175 mg/kg/day) exceeding Category 2 (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), IRIS TR (2010), Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005)). On the other hand, by the inhalation route, in a test in which rats were exposed to this substance (estimated as the vapour) by inhalation for 16 weeks (8 hours/day), effects on the respiratory organ (pulmonary hyperemia with alveolar septal distention) and the liver (fatty accumulation in hepatic lobules and Kupffer cells) were observed at a concentration (200 ppm: 790-802 mg/m3 (converted guidance value: 1.05-1.07 mg/L/6 hours)) slightly exceeding Category 2 (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), IRIS TR (2010), Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005)). However, in a 90-day inhalation exposure test with rats which was conducted after this test, only a decrease in total leukocyte counts and lymphocyte counts was observed, and no other hazardous effects were found at a high concentration (15.8 mg/L/6 hours) far exceeding the upper limit of Category 2. Therefore, IRIS questioned the reliability of these tests and judged that RfD calculation by the inhalation route was difficult due to lack of information (IRIS (2010)). From the above, although it was corresponding to "Not classified" by the oral route, it was judged that there were no adequate data to use for classification by the inhalation route because there is a lack of consistency in the target organs and effective concentrations between the 2 inhalation exposure tests with rats by the inhalation route. So, it was classified as "Classification not possible" due to lack of data. Besides, it was estimated that although IRIS (1998) was used as an information source in the previous classification, the revised IRIS (2010) was used as an information source this time, therefore, the classification result was changed. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
|---|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | It was classified as "Not classified" from 48-hour LC50 = 220 mg/L for crustacea (Daphnia magna) (Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005), Initial Risk Assessment (NITE, CERI, NEDO, 2008)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (water solubility = 4520 mg/L, PHYSPROP Database 2009), and it was classified as "Not classified" in acute toxicity. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
NOTE:
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