Item | Information |
---|---|
CAS RN | 1569-01-3 |
Chemical Name | 1-Propoxy-2-propanol |
Substance ID | m-nite-1569-01-3_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not an aerosol product. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of 48 degrees C [closed cup] (GESTIS (Access on May. 2011)), which is >= 23 degrees C and <= 60 degrees C, corresponds to Category 3. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is conceivable that it does not ignite at normal temperatures from an auto-ignition temperature of 252 degrees C (MSDS (Sigma-Aldrich) (Access on May. 2011)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for liquid substances. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | An organic compound contains oxygen which is not chemically bonded to elements other than carbon or hydrogen. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | An organic compound that does not contain -O-O- structure. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | On the basis of 4 LD50 values for rats (4370 mg/kg, 2510 mg/kg, 2890 mg/kg and 2800-3000 mg/kg) (all PATTY (5th, 2001)), it was classified as "Not classified" in JIS classification (Category 5 in UN GHS classification). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | On the basis of 4 LD50 values for rabbits (3550 mg/kg, 3810 mg/kg, 2820 mg/kg, 4370 mg/kg) (all PATTY (5th, 2001)), it was classified as "Not classified" in JIS classification (Category 5 in UN GHS classification). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No mortality in rats both in an 8-hour exposure to saturated vapour pressure concentration (11.7 mg/L) (converted to a 4-hour exposure equivalent value: 16.5 mg/L) and in 6-hour exposure to saturated vapour pressure concentration (10.8 mg/L) (converted to a 4-hour exposure equivalent value: 13.2 mg/L) were reported. (PATTY (5th, 2001) Because the category cannot be determined from the reports, it was classified as "Classification not possible." |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
On the basis that occlusive applications of 0.5 mL for 4 hours to rabbit skins produced mild to moderate erythema and edema in 4 out of 6 animals, but no necrosis or ulceration (PATTY (5th, 2001)), it was classified in Category 2. Besides, another test of an occlusive application to rabbits for 24 hours reports slightly irritant (ECETOC TR 95 (2005)), and another reports that severe irritation with persistent fissuring, desquamation, ulceration, and necrosis appeared under more rigorous conditions (PATTY (5th, 2001)). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
Because a reversing time is over 7-day in a test which reported that instillation of 0.005 to 0.1 mL into rabbit eyes caused severe conjunctivitis and a mild diffuse corneal injury which required 3 to 14 days for complete recovery (PATTY (5th, 2001)), it was classified in Category 2A. Besides, another test using rabbits reported that a moderate to severe irritation, a moderate corneal injury, and slight iritis observed reversed within a week (HSDB (2002)). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, negatives in an Ames test and a chromosomal aberration test using rat lymphocyte are reported as in vitro tests (ECETOC TR 95 (2005)). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In an inhalation test exposed to pregnant rats during an organogenetic period, only observed symptoms of periocular encrustation, microscopic evidence of a corneal ulcer in maternal animals, and poor ossification of proximal phalanges of the hind limb in fetuses, but no maternal or fetal toxicity were reported. (ECETOC TR 95 (2005)) In an inhalation test exposed to pregnant rabbits during an organogenetic period, symptoms of hypoactivity, ataxia, prostration, and emaciation, and a high degree of mortality (27.3%) in a high dose group, but no effects on pregnancy and fetal parameters were observed. (ECETOC TR 95 (2005)) However, it was classified as "Classification not possible" due to lack of data, because there are no data on adverse effects on sexual function and fertility caused by exposures prior to mating. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects) |
Warning |
H336 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
On the basis that anesthetization without mortality in an 8-hour inhalation exposure to rats, CNS depression by oral administration of high dose to rats, and comatose within 15 to 30 minutes of dermal application to rabbits were observed (all PATTY (5th, 2001)), it was classified in Category 3 (narcotic effects). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In an inhalation test exposed to two strains of rats (SD and Fisher 344) for 6 hours a day for 14 weeks, the female Fischer 344 rats showed decreased weight gains in a high concentration group (300 ppm), but both strains showed no difference from a control group in weights, food and water consumption, no abnormalities in necropsy, and no exposure-related changes in a pathological test. (ECETOC TR 95 (2005)). Three hundred ppm (1.475 mg/L) in the high concentration group, which is above the upper limit in Guidance value (1 mg/L), corresponds to "Not classified" in inhalation exposure, however, effects in other administration routes (oral, dermal) are unknown due to no data. Therefore, it was classified as "Classification not possible" in specific target organ toxicity (repeated exposures). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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