NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	1570-64-5
Chemical Name	4-chloro-o-cresol; 4-chloro-2-methyl phenol
Substance ID	m-nite-1570-64-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified	- -	-	-	Its autoignition point is 520degC (Hommel (1996)), which is >= 70degC.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Its melting point is 51degC (Howard (1997), Lide (88th, 2008), HODOC (3rd, 1997), HSDB (2003); Test methods applicable to solid (melting point <= 140degC) substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing chlorine and oxygen (but not fluorine), which are chemically bonded only with carbon or hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on its rat LD50 values of 2650, 2700, and 3195 mg/kg (SIDS (accessed in December 2008)), the substance was rated as "Not classified" using the JIS classification criteria (Category 5 in the United Nations classification).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on its rat LD50 value of 2240 mg/kg (OECD TG401, GLP-compliant) (SIDS (accessed in December 2008)), the substance was rated as "Not classified" using the JIS classification criteria (Category 5 in the United Nations classification).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Its saturated vapour pressure concentration is 17 mg/m3 (the unit converted). Since its rat LC50 values of 900 mg/m3/4h and > 30000 mg/m3/4h (SIDS (accessed in December 2008)) are higher than its saturated vapour pressure, the substance was classified into Category 3 using criteria for mist, GLP-compliant data and lower LC50 value.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In the rabbit tests (OECD TG404, GLP-compliant), the substance was evaluated to be highly irritating and its Primary Dermal Irritation Index value was 8 (which is the maximum score) (SIDS (accessed in December 2008)). In other two tests using rabbits, the substance was concluded to be corrosive (IUCLID (2000)). Based on these results, the substance was classified into Category 1. In other tests using unknown animal species, necrosis was detected 1 minute after the exposure (SIDS (accessed in December 2008), BUA (Report 134, 1993)). Although these results indicate a more refined classification of the substance into Category 1A, further classification was not considered due to lack of information on the species and quantity of animals tested.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Using rabbits, the substance has been documented to be strongly corrosive, and symptoms including hyperemia, and oedema and opacity of the cornea 1 hour after the exposure were detected. These symptoms lasted for 8 days and, additionally, staphyloma were observed (SIDS (accessed in December 2008)). Furthermore, in two other tests using rabbits, the substance was found to be irritating (IUCLID (2000)); and it is rated as Category 1 for skin corrosion and irritation. Thus, the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Not classified	- -	-	-	In guinea pigs (maximization tests: OECD TG406, GLP-compliant, Buehler tests: non-GLP), the substance was evaluated to be not sensitizing (SIDS (accessed in December 2008)). Thus, it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	Since in vivo mutagenicity tests using mouse somatic cells (micronucleus tests) (SIDS (accessed in December 2008)) yielded negative results, the substance was classified into "Not classified". Although positive results were found in micronucleus tests conducted long time ago, the EU-RAR determined that the negative results obtained from above mentioned tests were more reliable. As additional information, in vitro mutagenicity tests (chromosomal aberration tests using Chinese hamsters) yielded positive results (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in December 2008).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	In combined repeated oral dose toxicity study with the reproduction/developmental toxicity tests using both female and male rats (20-day forced oral administration during a 2-week period before mating and the gestation period: OECD TG422, GLP-compliant), reproductive or developmental toxicity was not observed (SIDS (accessed in December 2008)). However, since the information on teratogenicity of the offspring was not available, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	In dermal administration tests using rats of both sexes (1667-2880 mg/kg: OECD TG402), depressions and paresis were observed (SIDS (accessed in December 2008)). Thus, the substance was classified into Category 3 (narcotic effects).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In 28-day oral route tests using rats that received doses of 0-1000 mg/kg, epithelial hyperplasia in the mucosa of the urinary bladder was observed in the animal groups of both sexes that received 250 mg/kg (90-day correction value: 38.9 mg/kg/day); hyperplasia of squamous epithelium in the forestomach mucosa was detected in males; and a total serum bilirubin in males and relative weight of the kidney in females increase. However, the change in forestomach is thought to be caused by irritation to the digestive tracts, and the change in the urinary bladder is thought to be caused by a reactive increase by metabolites (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in December 2008). In other 28-day oral route tests using rats that received doses of 0-500 mg/kg, necrosis in the small intestine mucosa was detected in the animal groups that received 100 mg/kg (90-day correction value: 77.8 mg/kg) (SIDS (accessed in December 2008)). In combined repeated oral dose toxicity study with the reproduction/developmental toxicity tests using rats that received doses of 0-600 mg/kg bw for 40-45 days (OECD TG422, GLP-compliant), the LOEL was 600 mg/kg bw (90-day correction values: 266-300 mg/kg), which is considered to fall under "Not classified" category (SIDS (accessed in December 2008). Based on these results, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Since its 48-hour LC50 = 0.29 mg/L for crustaceans (Daphnia magna) (SIDS, 1998), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since its classification for acute toxicity is Category 1, and it is not rapidly degradable (non-biodegradable, BOD degradability: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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