NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	1600-27-7
Chemical Name	Mercury diacetate
Substance ID	m-nite-1600-27-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified	- -	-	-	Non-flammable (ICSC, 2000)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive or self-reactive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	Non-combustible (ICSC, 2000)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Non-combustible (ICSC, 2000)	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Stable to water (water solubility: 40g/100mL (20degC), ICSC (2000))	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified	- -	-	-	No data available, though being organic compounds containing oxygen bound to carbon and hydrogen. Classified into Division 6.1 (UN#1629) (UN Recommendations on the Transport of Dangerous Goods)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no "-O-O-" structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	Based on the rat LD50 (oral route) value of 41mg/kg (RTECS (2005)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	Based on the rabbit LD50 (dermal route) value of 570mg/kg (RTECS (2005)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Based on the description in ICSC (J) (2000): The substance causes "skin burn and pain; Corrosive to the eye/skin/respiratory tract; Oral ingestion produces corrosive effects." The substance is thus considered corrosive to the skin and classified into Category 1A-1C. However, it should be placed in Category 1, if further subclassification is needed.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Based on the description in ICSC (J) (2000): The substance causes "skin burn and pain; Corrosive to the eye/skin/respiratory tract; Oral ingestion causes corrosive effects." The substance is thus considered corrosive to the skin and classified into Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Mercury is classified into "Skin Sensitizing Substance" by the ad hoc committee of the Japanese Society of Occupational Allergy, and "Skin Sensitizing Substance: Group 1"* by the Japan Society for Occupational Health. These classifications, though not specifying mercury acetate, seem to include mercury compounds. Mercury acetate, which is a mercury compound, should thus cause skin sensitization. * There is a provision to the effect that "the category refers to the substance concerned and its compounds, but does not identify all substances causing respiratory/skin sensitization.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	Based on positive data on somatic cell mutagenicity tests in vivo and the absence of data on germ cell genotoxicity in vivo. Positive results (as mercury compounds) are also available in multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, but not used for effects assessment.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Not classified	- -	-	-	Due to the fact that the substance is classified as Category A4 (as metal mercury and inorganic mercury compounds) by ACGIH (2001) and Group 3 (as metal mercury and inorganic mercury compounds) by IARC (1993).	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Based on the evidence of adverse developmental effects on pups (though no data are available on maternal toxicity), described in ATSDR (1999), CICAD 50 (2003) and EHC 118 (1991). As for the reproductive toxicity of inorganic mercury compounds, refer to "ID285, Mercury Chloride (II), CAS 7487-94-7."	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 2 (kidney, respiratory organs)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	Based on the description in ICSC (J): the substance causes "corrosion of the respiratory tract; oral ingestion causes corrosion; may adversely affect the kidney" (ICSC (J) (2000)). Classified as priority 2 by ICSC (J). Note: According to CICAD 50 (2003), "renal failure, cardiovascular collapse and severe digestive organ damage are considered to be the causes of death following oral exposure to inorganic mercury. Most common findings among these are gastrointestinal tract lesion and renal failure. Exposure to inorganic mercury appears to induce nephrotic syndrome in humans."	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (kidney), Category 2 (nervous system)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	Based on the description in ICSC (J): the substance "adversely affects the central/peripheral nervous systems and kidney, may cause ataxia, sense/memory disorder, tremor, muscular weakness and kidney damage" (ICSC (J) (2000)). Also based on the evidence from animal studies: "partial hypertrophy and dilation of proximal renal tubules were initially observed, which progressed to increased dilation, hyaline cast, fibrosis and inflammation, and resulted eventually in cyst, extensive fibrosis and alterations in the glomerulus" (ATSDR (1999)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. Classified as priority 2 by ICSC. Note: According to CICAD 50 (2003), "renal failure, cardiovascular collapse and severe digestive organ damage are considered to be the causes of death following oral exposure to inorganic mercury. Most common findings among these are gastrointestinal tract lesion and renal failure. Exposure to inorganic mercury appears to induce nephrotic syndrome in humans."	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 96 hours LC50=0.06mg/L of the crustacea (Glass Shrimp) (ECETOC TR91, 2003).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since acute toxicity was Category 1 and it was a metallic compound, and since an underwater action and bio-accumulation were unknown, it was classified into Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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