Item | Information |
---|---|
CAS RN | 16752-77-5 |
Chemical Name | Methomyl |
Substance ID | m-nite-16752-77-5_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid or solid substances at 140degC are not available. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Containing no -0-0- structure | FY2006 | GHS Classification Manual (10 Feb, 2006) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
SPECIES: Rat (male) ENDPOINT: LD50 VALUE: 51 mg/kg REFERENCE SOURCE: Agricultural Chemicals abstracts |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Dermal) | Category 4 |
Warning |
H312 | P302+P352 P362+P364 P280 P312 P321 P501 |
It was set as Category 4 based on rat (female) LD50 value: 1050mg/kg (Agricultural Chemicals abstracts). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on 25% wettable powder rat (male) LC50 (1 hour) value: 1.99mg/L (4-hour equivalent 0.498mg/L), and 35.56% liquid medicine rat (female) LC50 (1 hour) value: 0.61mg/L (4-hour equivalent 0.15mg/L) (all are agricultural-chemicals abstracts), the lower value was adopted and it was set as Category 2. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | Since it was judged to have no stimulativeness in the skin irritation test on rabbits (Agricultural-Chemicals abstracts), it was classified as out of Category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | Since change of the eye which was adapted to criteria for assessments of irritation in eye irritation tests using rabbits was not admitted (Agricultural-Chemicals abstracts), it was set as the outside of Category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Skin sensitization | Not classified |
- |
- | - | Since the rate of a positivity in the Buehler method test using the guinea pigs was 0% (Agricultural Chemicals abstracts), it was put outside of the Category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Since we found the negative results by the micronucleus examination which used the mouse marrow cells, and by the chromosomal aberration test which used the rat marrow cells, which were the in vivo mutagenicity tests using the somatic cells (Agrichemical Abstracts), we classified it as Out Of Category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Carcinogenicity | Not classified |
- |
- | - | Since it was classified into A4 (ACGIH 7th, 2001) according to ACGIH, it carried out the outside of Category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Reproductive toxicity | Not classified |
- |
- | - | Since there is no reproductive toxicity in the dose causing general toxicity to parent animals in teratogenicity test of rat and rabbit, and in the reproduction study on rat (Agricultural-Chemicals abstracts), it was considered as on the outside of Categry. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
In the oral administration and inhalation exposure tests using rats, symptoms suggesting the influences on the nerve systems such as clonic convulsion, shivering, salivation etc. were observed with the given dosage of guidance value range of Category 1 (Agricultural chemical abstracts). So it was set as Category1 (nerve systems). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (nervous system, blood) |
Warning |
H373 | P260 P314 P501 |
It was classified to as category 2 (nervous systems, blood) according to the symptoms which shows the effects on nervous systems such as decreased brain cholinesterase activity, tremor, aggressive behavior, and hyperreactivity, and the effects on blood systems such as decreased haemoglobin, reduction of red cell count, increased reticulocyte counts, and erythroid hyperplasia in marrow in the repeated oral test using rats were acknowledged with the given dose of the guidance value range of Category 2 (all by agricultural-chemicals abstracts). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified into Category 1 from 48-hour EC50=0.009mg/L of Crustacea (Daphnia magna) (EHC64, 1996) . | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=0.6(PHYSPROP Database, 2005)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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