NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	16941-12-1
Chemical Name	Hexachloroplatinic acid(IV)
Substance ID	m-nite-16941-12-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified	- -	-	-	Classified into Not classified since the substance is Non-combustible solid (GESTIS (access on Aug. 2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified	- -	-	-	Classified into Not classified since the substance is Non-combustible solid (GESTIS (access on Aug. 2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Classified into Not classified since the substance is Non-combustible solid (GESTIS (access on Aug. 2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Classified into Not classified since the substance is "Easily soluble in water" (Merck (14th, 2006)) though it contains metal (Pt).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	No data available. As relevant information, the substance is classified into R25 in EU classification (EU-Annex I (2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available. As relevant information, in EU classification, the substance is classified into R34 (EU-Annex I (2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] Because the salts of this substance are corrosive to the eye from (1)-(3), and this substance and its salts are categorized into substances with a similar hazard as shown in (4), this substance was classified in Category 1 by using information on the salts. [Evidence Data] (1) It is reported that in an eye irritation test with rabbits (OECD TG405, GLP-compliant), after application of ammonium hexachloroplatinate, two out of three animals showed severe and irreversible effects such as opacity and necrosis of the cornea, moderate circumcorneal hyperemia of the iris, diffuse redness of the conjunctiva, swelling of the eyelids, discoloration of the eyes (REACH registration dossier (Accessed Dec. 2018)). (2) It is reported that in an eye irritation test with rabbits (OECD TG405, GLP-compliant), as the result of application of potassium hexachloroplatinate, after 24 hours, corneal opacity score was 4, conjunctival redness score 3 (diffuse redness), and chemosis score was 4 (half-closed lids due to swelling), the eye was filled with white mucus and discolored to grey, the animals were sacrificed due to the severity of the symptoms at 24 hours (REACH registration dossier (Accessed Dec. 2018)). (3) It is reported that in eye irritation tests on chlorinated platinates, ammonium tetrachloroplatinate was corrosive, and potassium tetrachloroplatinate and sodium hexachloroplatinate were irritating (EHC 125 (1991)). (4) In the notice No. 181 issued by Director of Labour Standards Bureau, the Ministry of Labour (1996), CAS RN was clearly mentioned for this substance together with other salts (potassium tetrachloroplatinate, ammonium tetrachloroplatinate, sodium hexachloroplatinate, potassium hexachloroplatinate, and ammonium hexachloroplatinate), and it is also written that they cause anterior eye disorders, eye irritation, lacrimation, conjunctival hyperemia as symptoms and disorders. [Rationale for the Classification] Because the salts of this substance are corrosive to the eye from (1)-(3), and this substance and its salts are categorized into substances with a similar hazard as shown in (4), this substance was classified in Category 1 by using information on the salts. [Evidence Data] (1) It is reported that in an eye irritation test with rabbits (OECD TG405, GLP-compliant), after application of ammonium hexachloroplatinate, two out of three animals showed severe and irreversible effects such as opacity and necrosis of the cornea, moderate circumcorneal hyperemia of the iris, diffuse redness of the conjunctiva, swelling of the eyelids, discoloration of the eyes (REACH registration dossier (Accessed Dec. 2018)). (2) It is reported that in an eye irritation test with rabbits (OECD TG405, GLP-compliant), as the result of application of potassium hexachloroplatinate, after 24 hours, corneal opacity score was 4, conjunctival redness score 3 (diffuse redness), and chemosis score was 4 (half-closed lids due to swelling), the eye was filled with white mucus and discolored to grey, the animals were sacrificed due to the severity of the symptoms at 24 hours (REACH registration dossier (Accessed Dec. 2018)). (3) It is reported that in eye irritation tests on chlorinated platinates, ammonium tetrachloroplatinate was corrosive, and potassium tetrachloroplatinate and sodium hexachloroplatinate were irritating (EHC 125 (1991)). (4) In the notice No. 181 issued by Director of Labour Standards Bureau, the Ministry of Labour (1996), CAS RN was clearly mentioned for this substance together with other salts (potassium tetrachloroplatinate, ammonium tetrachloroplatinate, sodium hexachloroplatinate, potassium hexachloroplatinate, and ammonium hexachloroplatinate), and it is also written that they cause anterior eye disorders, eye irritation, lacrimation, conjunctival hyperemia as symptoms and disorders. [Reference Data, etc.] (5) In the announcement No. 33 of the Ministry of Labour (1996) (revised by the announcement No. 316 of the Ministry of Health, Labour and Welfare, 2013), this substance is designated as "chlorinated platinic acid and its compounds" in Simple chemical substances or compounds designated by the Minister of Health, Labour and Welfare based on Appended Table 1-2, (iv) 1 of the Ordinance for Enforcement of the Labor Standards Act, and a disease principally having specific symptoms and disorders (skin disorders, anterior eye disorders, or respiratory tract disorders) due to work involving exposure to this substance was designated as an occupational disease by the Minister of Health, Labour and Welfare. (6) In the notice No. 0811001 issued by Director of Labour Standards Bureau, the Ministry of Labour (2003), this substance is designated as "chlorinated platinic acid and its compounds" among hazardous substances for which installation of protective equipment to prevent eye disorders such as protective glasses is mandated in Article 593 in the Industrial Safety and Health Regulations. (7) It is reported that in an eye irritation test with rabbits (OECD TG405, GLP-compliant), after application of potassium tetrachloroplatinate, either of corneal opacity, iridial and conjunctival redness, or chemosis did not resolve in two out of three animals 72 hours after application (REACH registration dossier (Accessed Dec. 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	This substance is one of the compounds responsible for platinum salt hypersensitivity. The signs and symptoms of hypersensitivity include urticarial, contact dermatitis of the skin, and respiratory disorders ranging from sneezing, shortness of breath, and cyanosis to severe asthma (EHC (J) No.125 (2000)). In Japan Society For Occupational Health (JSOH), the following statement is found: "occupational exposure to water-soluble platinum salts causes allergic reaction, and asthmatic symptoms and skin sensitization are observed". Water-soluble platinum salts were classified as sensitizer (Category 1 for the respiratory tract and skin) (Recommendations for allowable concentrations (2008 and 2000)). The substance is water-soluble (Merck (14th, 2006)). Based on these information, the substance was classified into Category 1. As relevant information, the substance is classified into R42/43 in EU classification (EU-Annex I (access on July 2009)) and Asthma mark is assigned in ACGIH (ACGIH-TLV (2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	The substance is one of the compounds responsible for platinum salt hypersensitivity. The signs and symptoms of hypersensitivity include urticarial, contact dermatitis of the skin, and respiratory disorders ranging from sneezing, shortness of breath, and cyanosis to severe asthma (EHC (J) No.125 (2000)). In Japan Society For Occupational Health (JSOH), the following statement is found: "occupational exposure to water-soluble platinum salts causes allergic reaction, and asthmatic symptoms and skin sensitization are observed". Water-soluble platinum salts were classified as sensitizer (Category 1 for the respiratory tract and skin) (Recommendations for allowable concentrations (vol.50 (2008) and vol.42 (2000)). The substance is water-soluble (Merck (14th, 2006)). The substance was classified into Category 1. As relevant information, the substance is classified into R42/43 in EU classification (EU-Annex I (2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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