NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	1698-60-8
Chemical Name	chloridazon (ISO); 5-amino-4-chloro-2-phenylpyridazine-3-(2H)-one; pyrazon
Substance ID	m-nite-1698-60-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing chlorine and oxygen (but not fluorine), which are chemically bonded only to carbon or hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Its rat LD50 values are 647, 1210, 1000-1470, 1459, 3000, 3030, 3400, 3600, 4200 mg/kg bw (IUCLID (2000)); these values include 4 cases of Category 4 and 5 cases of "Not classified" category. From these results, the substance was classified into "Not classified" using the JIS classification criteria (Category 5 in the United Nations classification).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on its rat LD50 values of > 2500 and > 5000 mg/kg, and its rabbit LD50 value of > 4000 mg/kg (IUCLID (2000)), the substance was classified into "Not classified" (Category 5 or "Not classified" in the United Nations classification).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Its rat LC50 values are > 0.15 mg/L/4h and > 0.25 mg/L/4h (IUCLID (2000)), which are less than its saturated vapour pressure concentration of 0.598 mg/L. The concentration of 0.25 mg/L is a concentration of pesticide formulations and is equivalent to 0.16 mg/L of this substance. Overall, based on these LC50 values of > 0.15 mg/L (conversion value: 17 ppm) and > 0.16 mg/L (conversion value: 18 ppm), the category for this substance cannot be determined; thus, it was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Since its rat LC50 value of > 30.8 mg/L/4h (IUCLID (2000)) is higher than its saturated vapour pressure concentration of 0.598 mg/L, the substance was in a mist state. From these results, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Using rabbits, the substance has been evaluated to be not irritating in three tests, and slightly irritating in four tests (IUCLID (2000)). No other detailed information was obtained, and the substance was classified into "Classification not possible" due to lack of data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	Using rabbits, the substance has been evaluated to be not irritating in four studies, and slightly irritating in one study (IUCLID (2000)). In two tests in which no irritation was detected in rabbits, it is documented that redness was observed 1 and 24 hours after the application and the symptom healed in 8 days; or slight corneal hyperemia was observed 6 days after the application and it healed in 4 to 5 days. Since the symptoms were mild and the substance was evaluated to be not irritating, it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Not classified	- -	-	-	In guinea pigs (maximization tests: OECD 406, GLP-compliant), the substance was evaluated to be not sensitizing (IUCLID (2000)). In humans, allergic reactions were not detected in patch tests (IUCLID (2000)). Based on these results, the substance was classified into "Not classified". According to the EU, the substance was rated as R43 (equivalent to Category 1) (EU-Annex 1 (accessed in December 2008)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	Since in vivo tests using mice (dominant lethal tests and micronucleus tests) yielded negative results (IUCLID (2000)), the substance was classified into "Not classified". Among in vitro tests, Ames tests and unscheduled DNA synthesis tests yielded negative results.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Not classified	- -	-	-	Signs of carcinogenicity were not detected in the following tests documented: 103-109-week oral administration tests using rats (SD) that were applied with 150 to 4050 ppm, 81-96-week oral administration tests using mice (CFLP) that were applied with 160 to 20000 ppm (IUCLID (2000)), mixed diet tests using mice (B6C3F1/CrlBr) that were applied with 0 to 5000 ppm, and mixed diet tests using rats that were applied with 0 to 1000 ppm (IUCLID (2000)). Based on these results, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Not classified	- -	-	-	In 3-generation tests using rats that received 150 to 1350 ppm, symptoms of reproductive toxicity (mating, pregnancy rate, gestational period, and litter parameters) or teratogenicity were not detected (IUCLID (2000)). In teratogenicity tests using rats that received 0 to 250 mg/kg bw (OECD 414, GLP-compliant) and rabbits that received 55 to 495 mg/kg bw (OECD 414, GLP-compliant), no signs of teratogenicity, embryotoxicity, or fetal toxicity were observed at doses that showed toxic effects on maternal animals (IUCLID (2000)). In other tests, either reproductive toxicity or developmental toxicity was detected in mice that received 5000-10000 ppm (FDA guidelines) or rats that received 0 to 1600 ppm (HSDB (2007)). Based on these negative results, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	When pyrason was given intragastrically to rats, mice, cats, and guinea pigs, increased reflex excitability, disordered movement coordination, tonic convulsions, hypotension and decreased body temperatures were observed in the animal groups that received the doses of 2 to 4 ml (values corrected for specific gravity: 3.08-6.16 mg (PM (14th, 2006)) (IUCLID (2000)). However, administration doses of the solid substance were documented in terms of volume, doses per body weight could not be calculated, and only one dataset of a forced oral administration test was available. Thus, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In 35-day mixed diet tests using rats that received doses of 300-19200 ppm (90-day conversion values: 9.7-622 mg/kg bw), the effects of the substance observed across all the dose groups tested were limited to an increase in absolute and relative liver weight, and the effects on clinicochemical parameters (such as reduced glucose and increased bilirubin) (IUCLID (2000)). In addition, in 3-month mixed diet tests using dogs that received doses of 100 to 10000 ppm (2.4-326.6 mg/kg), findings were limited in changes in organ weight and clinicochemical parameters observed at 326.6 mg/kg (IUCLID (2000)); however, these results indicate that the substance is to be categorized into "Not classified" (oral route). Since information on other administration routes is not available, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Since its 72-hour EC50 = 0.6 mg/L for algae (Pseudokirchneriella subcapitata) (IUCLID, 2000), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since its classification for acute toxicity is Category 1 and it is not rapidly degradable (SRC: BioWin v4.10), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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