Item | Information |
---|---|
CAS RN | 17689-77-9 |
Chemical Name | Ethyltriacetoxysilane |
Substance ID | m-nite-17689-77-9_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified |
- |
- | - | It was classified as "Not classified" from a flash point of 106 deg C (closed cup) (GESTIS (Accessed Jan. 2019)). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains a metalloid (Si), but from data on water solubility: 41.6 g/L (SIDS (2005)), it is estimated that it does not react vigorously with water. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen which is chemically bonded to the element other than carbon or hydrogen (Si). However, the classification is not possible due to no data on oxidization. |
FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
It was classified in Category 4 based on an LD50 value of 1,462 mg/kg for rats [OECD TG401; GLP] (SIDS (2005)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. Besides, for acetic acid, the related substance, there is a report on an LD50 value of 1,060 mg/kg for rabbits (SIDS (2005)), corresponding to Category 4. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. Besides, for acetic acid, the related substance, there is a report on an LC50 value by 4-hour exposure for rats of 11.4 mg/L (4,641 ppm), corresponding to Category 4 (regardless of whether mist was mixed or not). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
In a test by a 3-minute semi-occlusive application of 0.5 mL of undiluted this substance to the rabbit skin, severe lesions were observed 72 hours after the application in four out of six animals, and reversibility was slight during a 14-day observation period. And the primary dermal irritation index (PDII) was 4.28, and it was judged as corrosive (SIDS (2005)). Therefore, it was classified in Category 1. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
It was classified in Category 1 because it was classified as a corrosive substance in skin corrosion/irritation. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, as for in vitro mutagenicity tests, it was reported to be negative in an Ames test (SIDS (2005)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 2 (systemic) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
In an acute oral toxicity test with rats (OECD TG401, GLP-compliant), deaths occurred at or above 1500 mg/kg corresponding to the guidance values for Category 2, and symptoms such as decreased activity, lethargy, lacrimation, salivation, irregular gait, hunched posture, and labored respiration are reported (SIDS (2005)), but the target organ cannot be specified. Therefore, it was classified in Category 2 (systemic toxicity). Besides, as remarkable findings at necropsy, discoloration, adhesions, and thickening of the mucous membranes in the stomach/gastrointestinal tract were dose-dependently observed (SIDS (2005)), but it was not adopted for the rationale for classification because the above findings in the gastrointestinal tract were regarded as local effects by oral administration of a corrosive substance (this substance was classified as a corrosive substance for the skin and eye). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Data are lacking. Besides, after 7-day repeated oral administration to rats, gastrointestinal tract injury characterized by ulceration of the esophagus and stomach was observed at or above 100 mg/kg/day (SIDS (2005)), but all these effects were regarded as local effects due to irritation of acetic acid, which was produced by hydrolysis of this substance. And it is described that in a test by inhalation exposure to acetic acid for 3-35 days in rats and mice, decreased activity, behavioral changes, and reduced work capacity at or above 15 ppm, and decreased growth, increased kidney weights, and signs of kidney damage at 23-31 ppm were found (SIDS (2005)), but the details are unknown. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | it was classified as "Not classified" from 48-hour EC50 = 6000 mg/L for crustacea (Daphnia magna) for acetic acid (pH adjustment), the hydrolysis product (SIDS, 2006). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. As for acetic acid, the hydrolysis product, it is not water-insoluble (water solubility: 243000 mg/L, PHYSPROP Database, 2009), and it corresponds to "Not classified" in acute toxicity for crustacea (SIDS, 2006), therefore the substance was classified as "Not classified." | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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