Item | Information |
---|---|
CAS RN | 178961-20-1 |
Chemical Name | 2-Chloro-N-(2-ethyl-6-methylphenyl)-N-[(R)-1-methoxypropan-2-yl]acetamide; (S)-Metolachlor |
Substance ID | m-nite-178961-20-1_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | |
Sample SDS by MHLW (External link) | |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to liquid substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Not classified" for this hazard class (GHS classification result in FY2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Not classified" for this hazard class (GHS classification result in FY2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] The classification is not possible from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Classification not possible" for this hazard class (GHS classification result in FY2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Not classified" for this hazard class (GHS classification result in FY2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Not classified" for this hazard class (GHS classification result in FY2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Not classified" for this hazard class (GHS classification result in FY2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] The classification is not possible from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Classification not possible" for this hazard class (GHS classification result in FY2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
[Rationale for the Classification] It was classified in Category 1 from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)) (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified in Category 1 for this hazard class (GHS classification result in FY2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) Based on the comparison between the test results on the racemic mixture of this substance and those on the S-metolachlor, it was considered that both had similar dynamics and metabolism, and their toxicological profile and the degree of toxicity were almost the same (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor (CAS RN 51528-45-2) containing this substance (R isomer) was classified as "Not classified" for this hazard class (GHS Classification Results in FY2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Classification not possible." [Evidence Data] (1) Based on the comparison between the test results on the racemic mixture of this substance and those on the S-metolachlor, it was considered that both had similar dynamics and metabolism, and their toxicological profile and the degree of toxicity were almost the same (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor (CAS RN 51528-45-2) containing this substance (R isomer) was classified as "Classification not possible" for this hazard class (GHS Classification Results in FY2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) Based on the comparison between the test results on the racemic mixture of this substance and those on the S-metolachlor, it was considered that both had similar dynamics and metabolism, and their toxicological profile and the degree of toxicity were almost the same (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor (CAS RN 51528-45-2) containing this substance (R isomer) was classified as "Not classified" for this hazard class (GHS Classification Results in FY2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1 (central nervous system). [Evidence Data] (1) Based on the comparison between the test results on the racemic mixture of this substance and those on the S-metolachlor, it was considered that both had similar dynamics and metabolism, and their toxicological profile and the degree of toxicity were almost the same (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor (CAS RN 51528-45-2) containing this substance (R isomer) was classified in Category 1 (central nervous system) for this hazard class (GHS Classification Results in FY2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Classification not possible." [Evidence Data] (1) Based on the comparison between the test results on the racemic mixture of this substance and those on the S-metolachlor, it was considered that both had similar dynamics and metabolism, and their toxicological profile and the degree of toxicity were almost the same (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor (CAS RN 51528-45-2) containing this substance (R isomer) was classified as "Classification not possible" for this hazard class (GHS Classification Results in FY2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] The classification is not possible from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Classification not possible" for this hazard class (GHS classification result in FY2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
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