NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	18454-12-1
Chemical Name	dilead chromate oxide
Substance ID	m-nite-18454-12-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified	- -	-	-	Since its melting point is high (920 degC), and it was considered to be nonflammable also from its composition, it was classified as out of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	The melting point was high (920 degC) and it was considered to be nonflammable also in composition, and was defined as "outside of Category".	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Since the melting point is high (920 degC) and also was considered to be nonflammable in composition, it is set to the outside of category.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Stable to water (insoluble in water)	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Data without. In addition, there is the description that "caustics or irritation" as an influence of chromate and its salts to the skin is seen (IRIS (1998), DHP (13th, 2002), DFGOT vol.3 (1992)). Moreover, also refer to the information on lead chromate (VI) (ID 21, Chemical Abstracts Service:7758-97-6).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	Although there is no report of this material itself, chromium and chromium compound were classified into "the 2nd group (material considered that there is probably sensitizing to human)" in Japan Association of Industrial Health, and chromium was classified into the material with respiratory sensitization in Japanese Society of Occupational Allergy Special Committee, this product thought that it had respiratory sensitization and was set to Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	In Japan Society for Occupational Health, although there was no report of this material itself, since chromium and chromium compound were classified into "the 1st group (material which has sensitizing clearly to human)", this product thought that it had skin sensitization, and was set to Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	No data. In addition, although this product is the insoluble hexavalent chromium compounds, the mutagenicity knowledge in in vivo is indicated about many flood solubility hexavalent chromium compounds (NTP RoC (11th, 2005), IARC49 (1990), EU-RAR (2005)). Refer to potassium dichromate (ID 262, Chemical Abstracts Service:7778-50-9). Moreover, inorganic lead compounds describes that a chromosome aberration is induced to humans in ATSDR (draft, 2005), and is classified into the germ cell mutagenicities 3A (equivalent to GHS Category 1B-2) in MAK/BAT (2005).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	As hexavalent chromium compounds, since it was was classified K (Chromium hexavalent (VI) compounds) in NTP (2005), group 1 (Chromium(VI)) in IARC (1990), and A (Chromium(VI), Inhalation route) in EPA (1986), respectively. So it was classified into Category 1A.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 1A	Danger	H360	P308+P313 P201 P202 P280 P405 P501	Although there is no this product data, there is the description that a lead (inorganic lead compound) shows humans reproductive toxicity (ATSDR (draft, 2005), Chemically Induced Birth Defects (3rd ed, 2000)), and it was set as Category 1A due to the category of reproductive toxicity has been done also by ACGIH (ACGIH-TLV (2005)). In addition, also refer to potassium dichromate (ID 262, CAS: 7778-50-9) as reproductive toxicity of hexavalent chromium compounds.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, blood, kidney)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	Although there is no data about this product, since about humans, as toxicity of the inorganic lead compounds "symptom that the acute influence of inorganic leads and chronic influence are almost the same is observed" (CERI Hazard Data 2001-9, 2002), in ACGIH-TLV (2005), it effects on the central nervous systems, blood, renal as inorganic leads compound, it was considered as Category 1 (a central nervous system, blood, kidney). In addition, there is description that when orally or percutaneous absorption is carried out as acute toxicities of the hexavalent chromium compound, vomiting, diarrhea, a spasm, a hemorrhagic nephritis, etc. are caused (DFGOT vol.3 (1992), DHP (13th, 2002)).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system, blood, kidney)	Danger	H372	P260 P264 P270 P314 P501	Although there was no data of this product, as an inorganic lead compound, it effects on central nervous systems, blood, and kidney (ACGIH-TLV (2005) in Priority 1 document). It was classified into Category 1 (central nervous system, blood, kidney). In addition, there is a description of effects on a kidney, nasal septum perforation, ulcers, etc. as chronic toxicity of hexavalent chromium compounds (ACGIH (7th, 2001), IRIS (1998), DHP (13th, 2002)).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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