NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	1918-02-1
Chemical Name	Picloram
Substance ID	m-nite-1918-02-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Classification not possible	- -	-	-	No data available. Besides, there is information that it is flammable (ICSC (2012)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available. Besides, it is described that it is slightly corrosive to mild steel only(HSDB (Access on Aug 2014)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	There are 5 reports of LD50 values of 4,012 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)), >5,000 mg/kg (male), 4,012 mg/kg (female) (EPA Pesticide (1995)), 8,200 mg/kg (ACGIH (7th, 2001)) and about 8,200 mg/kg (IARC 53 (1991)) for rats. It was classified as "Not classified" (2 values corresponded to Category 5 in UN GHS classification, and 3 values to "Not classified.") to which the larger number of values corresponded based on the revision of the GHS classification guidance for the Japanese Government.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on reports of LD50 values of >2,000 mg/kg (female and male) (EPA Pesticide (1995)) and >4,000 mg/kg (IARC 53 (1991)) for rabbits, it was classified as "Not classified." New information sources (EPA Pesticide (1995), IARC 53 (1991)) were added, and the classification was revised.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a report of an LC50 value (4 hours) of > 0.035 mg/L for rats (EPA Pesticide (1995)). Besides, since the LC50 value was higher than the saturated vapor concentration (7.8*10-13), the reference value as the dust was applied.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Not classified	- -	-	-	There is a report that no skin irritation was observed in a test with rats, and it was classified in IV in the category of EPA Pesticide (EPA Pesticide (1995)). In addition, there is a report that in a skin irritation test with rabbits, slight erythema was observed in 5 of 6 animals after application of a formulation containing 20% of this substance but disappeared within 72 hours (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.12 (1992)). On the other hand, although there are descriptions that it was irritating to the skin (Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010), HSDB (Access on June 2014)), and that it was mildly irritating (HSDB (Access on June 2014)), the details were unknown. From the above results, it was classified as "Not classified" (Category 3 in UN GHS classification). Information was added, and classification was conducted according to the GHS Classification Guidance for the Japanese Government.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	There is a report that it was moderately irritating to the eyes in a test with rats, and it was classified in III in the category of EPA Pesticide (EPA Pesticide (1995)). In addition, there is a report that there was moderate irritation which was reversible (HSDB (Access on June 2014)). From the above results, it was judged as Category 2. Since there was no detailed description of recovery properties, no subcategorization was done. Besides, there is a report that in a primary irritation test with rabbits, conjunctival edema, secretion and redness of the iris were observed after application of a 20% formulation of this substance but disappeared 14 days after treatment (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.12 (1992)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Not classified	- -	-	-	There are reports that no positive reaction was observed in a patch test with 29 healthy men under the modified Draize method (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.12 (1992)), and that no sensitization was observed in a volunteer experiment with application to the skin at a 5% concentration (Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)). In addition, there is a report that there was no sensitization in a test with rats (EPA Pesticide (1995)). From the above results, it was judged as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mice, chromosomal aberration tests with rats and mice and an unscheduled DNA synthesis test (UDS test) with cultured rat primary hepatocytes (ACGIH (7th, 2001), EPA Pesticide (1995), IARC 53 (1991), Pesticide safety information (Japan Crop Protection Association, Access on June 2014)). As for in vitro, although it showed negative results all in multiple tests, including bacterial reverse mutation tests, gene mutation tests and chromosomal aberration tests with cultured mammalian cells (ACGIH (7th, 2001), IARC 53 (1991), EPA Pesticide (1995), NTP DB (Access on July 2014), Pesticide safety information (Japan Crop Protection Association, Access on June 2014)), there were also positive results in a chromosomal aberration test and a sister chromatid exchange test with cultured mammalian cells (NTP DB (Access on July 2014)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Since it was classified in Group 3 by IARC (IARC 53 (1991)), in A4 by ACGIH (ACGIH (7th, 2001)) and as Group E by EPA (EPA Pesticide (1995)), the classification by IARC and ACGIH was prioritized, therefore, it was classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Not classified	- -	-	-	In a two-generation reproductive toxicity study with rats by the oral route, no reproductive toxicity was observed even at a dose (1,000 mg/kg/day) where parental toxicities (histopathological lesions in the kidney, occult blood in urine, decreased urine specific gravity, increased absolute and relative kidney weight, etc.) were observed (EPA Pesticide (1995)). There are reports that neither fetotoxicity nor teratogenicity was observed even at doses where maternal toxicity was observed in teratogenicity tests with rats and rabbits by the oral route (EPA Pesticide (1995)), and that in a teratogenicity test with rats by the oral route, although retarded fetal growth was observed at a dose (1,000 mg/kg/day) where maternal toxicity (details unknown) was observed, no effects on teratogenicity, postnatal survival rate and development were observed (ACGIH (7th, 2001), IARC 53 (1991)). Therefore, it was judged that there was no reproductive toxicity, and it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	In humans, there are descriptions of irritation to the respiratory tract by the inhalation route, of nausea, burning sensation and cough by the oral route, and of nausea by the excessive ingestion (Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010), HSDB (Access on June 2014)), and in experimental animals, although details such as the route were unknown, there are descriptions of hair loss, tachycardia, ataxia, diarrhea and leukopenia (HSDB (Access on June 2014)). From the above, this substance was considered to be irritating to the respiratory tract, and it was classified in Category 3 (respiratory tract irritation).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)	Warning	H373	P260 P314 P501	In 13-week feeding tests with mice and rats, no effects were observed in any tests within or lower than the dose range of Category 2 (ACGIH (7th, 2001), EPA Pesticide (1995), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)). However, in a 2-year feeding test with rats, increased liver weight and centrilobular hepatocellular hypertrophy were observed at 60 mg/kg/day (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), IRIS (1992)), and in a 6-month feeding test with dogs, increased liver weight (male only) was observed at 35 mg/kg/day (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), IRIS (1992)). The US EPA considered 35 mg/kg/day where increased liver weight was observed in a 6-month feeding test with dogs as the lowest-observed-effect level (LOEL) and calculated the oral RfD value from a no-observed-effect level (NOEL) of 7 mg/kg/day (IRIS (1992)). Therefore, although no serious change was observed in the liver, it was classified in Category 2 (liver) in consideration of the opinion of EPA.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 96-hour LC50=0.027mg/L of Crustacea (Amphipod) (HSDB, 2004).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=0.3(PHYSPROP Database, 2005)).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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