NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	1929-82-4
Chemical Name	2-Chloro-6-trichloromethylpyridine; Nitrapyrin
Substance ID	m-nite-1929-82-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	There is information that it is combustible (ICSC (2001)), but the classification is not possible due to no data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	Not classified	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 4. [Evidence Data] (1) LD50 for rats: 940 mg/kg (ACGIH (7th, 2019)) (2) LD50 for rats: males: 1,070 mg/kg, females: 1,230 mg/kg (EPA Pesticide (2005), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	[Rationale for the Classification] Based on (1), by putting an emphasis on a GLP test and adopting it, it was classified as "Not classified." [Evidence Data] (1) LD50 for rabbits: >2,000 mg/kg (EPA Pesticide (2005), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)) [Reference Data, etc.] (2) LD50 for rabbits: 850 mg/kg (ACGIH (7th, 2019))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Based on (1), since the category could not be specified, it was classified as "Classification not possible." [Evidence Data] (1) LC50 (4 hours) for rats: >0.03 mg/L (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007), EPA Pesticide (2005))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." The category was changed due to new data obtained. [Evidence Data] (1) In a skin irritation test with rabbits according to OECD TG 404 and EPA OPPTS 870.2500, mean scores at 24/48/72 hours were all less than 2.3 (REACH registration dossier (Access on September 2019), EPA Pesticide (2005), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	[Rationale for the Classification] Based on (1), it was classified in Category 2A. [Evidence Data] (1) In an eye irritation test with rabbits according to OECD TG 405 and EPA OPPTS 870.2400, the mean scores at 24/48/72 hours for conjunctival redness/edema, corneal opacity and the iris were 2.6/1.3, 0.3 and 1.0, respectively. In addition, all were resolved 21 days post-exposure (REACH registration dossier (Access on September 2019), EPA Pesticide (2005), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Though there is data in (1), it was not data of a standard test. Therefore, it was classified as "Classification not possible" due to lack of data. [Reference Data, etc.] (1) In a skin sensitization test (modified Maguire method) with guinea pigs, a positive result (positive rate 30%) was reported (EPA Pesticide (2005), REACH registration dossier (Access on September 2019), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Not classified	- -	-	-	[Rationale for the Classification] From (1) and (2), based on expert judgment, it was classified as "Not classified." [Evidence Data] (1) As for in vivo, there is a report of a negative result in a micronucleus test with mice (EPA Pesticide (2005), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)). (2) As for in vitro, there are reports of negative results in bacterial reverse mutation tests, except for some bacterial strains, and an unscheduled DNA synthesis test and a gene mutation test (HGPRT) with cultured mammalian cells (EPA Pesticide (2005), NTP DB (Access on July 2019), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)). [Reference Data, etc.] (3) It is predicted that this substance is mutagenic based on certain structural activity factors (EPA Pesticide (2005)). (4) It was concluded that no effects on fertility, no teratogenicity and no genotoxicity causing trouble in vivo were observed in the results of various toxicity tests (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Based on the classification results by other organizations in (1), it was classified as "Classification not possible" in accordance with the GHS Classification Guidance for the Japanese Government. [Evidence Data] (1) As for the classification results by domestic and international organizations, it was classified as A4 by ACGIH (ACGIH (7th, 2019)), as "NL (Not Likely to be Carcinogenic to Humans)" by EPA (EPA Annual Cancer Report (2018): classified in 2018).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Not classified	- -	-	-	[Rationale for the Classification] Based on (1)-(3), since no reproductive toxicity corresponding to any category was observed, it was classified as "Not classified." The classification result was changed by the use of new information sources. [Evidence Data] (1) In a two-generation reproduction toxicity study with rats by oral dose, increased absolute and relative weights of the liver and kidney, and diffuse centrilobular hepatocyte hypertrophy were observed in parental animals, and decreased body weight gain and centrilobular hepatocyte vacuolation with fatty degeneration in the liver were observed in pups. However, no effects on fertility were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)). (2) In a developmental toxicity test in which female rats were orally administered on gestational days 6-15, a decrease in body weights, and increases in skeletal variations (lumbar ribs) and delayed ossification of the sternebra were observed in pups at the dose where maternal toxicity (decreased body weight gain and decreased feed consumption) was observed. However, no teratogenicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)). (3) In a developmental toxicity test in which female rabbits were orally administered on gestational days 6-18, an increased incidence of crooked hyoid bones was observed in pups at the dose where maternal toxicity (decreased body weight gain and increased absolute and relative weights of the liver) was observed. However, no teratogenicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	[Rationale for the Classification] The reports of single inhalation exposure in humans to this substance were not obtained from information sources in List 1 and List 2. Based on information about experimental animals in (1), it was classified in Category 2 (central nervous system). Since information adopted as evidence of respiratory tract irritation in the previous classification was from the reference in List 3, it was not adopted. Therefore, the classification result was changed. [Evidence Data] (1) In an acute neurotoxicity test with rats, following a single oral dose of 400 mg/kg (corresponding to Category 2) of this substance, slight tremors, gait incoordination and decreased total motor activity were observed (Federal Register vol. 82, No. 229, November 30, 2017).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, kidney)	Warning	H373	P260 P314 P501	[Rationale for the Classification] Based on (1)-(4), since effects on the liver and kidney were observed within the range of Category 2 by oral administration to experimental animals, it was classified in Category 2 (liver, kidney). [Evidence Data] (1) In a test in which rats were dosed by feeding for 90 days, increased weight of the liver, hepatocyte hypertrophy, lesions of the renal tubules, etc. were observed at or above 40 mg/kg/day (within the range of Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)). (2) In a combined chronic toxicity/carcinogenicity study (feeding) with rats for 2 years, increased weights of the liver and kidney, hepatocellular hypertrophy and vacuolation (fatty degeneration), and chronic progressive glomerulonephropathy were observed in males and females at 60 mg/kg/day (within the range of Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007), EPA Pesticide (2005)). (3) In a carcinogenicity study (feeding) with mice for 2 years, homogeneous cellular changes in the centrilobular hepatocytes were observed in males and females at 25 mg/kg/day (within the range of Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)). (4) In a chronic toxicity test (feeding) with dogs for 1 year, increases in ALP activity and total cholesterol concentration, increased weight of the liver and hepatocyte hypertrophy were observed at 15 mg/kg/day (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 72-hour EC50 (growth) = 1.1 mg/L for algae (Pseudokirchneriella subcapitata) (EPA AQUIRE: 2018, EPA Pesticide Ecotoxicity Database (1992)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 2 because it is not rapidly degradable and was classified in Category 2 in acute toxicity.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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