NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	21908-53-2
Chemical Name	Mercury(II) oxide
Substance ID	m-nite-21908-53-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (ICSC (2001)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (ICSC (2001)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (2001)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Because the observation result of being insoluble in water (ICSC (2001)) was obtained, it is estimated that it does not react vigorously with water.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen (but not halogen), but the classification is not possible due to no data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	Based on a report of an LD50 value of 18 mg/kg for rats (GESTIS (Access on September 2014) original reference: National Technical Information Service. vol. PB214 270), it was classified in Category 2. A new information source (GESTIS (Access on September 2014)) was added and the category was revised.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	Based on a report of an LD50 value of 315 mg/kg for rats (GESTIS (Access on September 2014) original reference: Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. vol. 25 (7), Pg. 27, 1981), it was classified in Category 3. A new information source was added and the category was revised.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Although there is no specific description, since there is a description that this substance was irritating to the skin (CICAD 50 (2003)), it was classified in Category 2.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Although there is no specific description, since there is a description that this substance was irritating to the eyes (CICAD 50 (2003)), it was classified in Category 2.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	The Japan Society For Occupational Health classifies mercury (the substance itself and its compounds) in occupational skin sensitizers Group 1. Although this substance is not specified in this classification, this substance is considered to be included in mercury compounds, therefore it was classified in Category 1. Besides, according to the classification of the Japan Society For Occupational Health, there is a provision that "not all substances that cause sensitization have been identified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Since it was classified in Group 3 (as metallic mercury and inorganic mercury compounds) by IARC (IARC 58 (1993)) and in A4 (as metallic mercury and inorganic mercury compounds) by ACGIH (ACGIH (7th, 2001)), it was classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	In a teratogenicity study by the oral route with rats, at doses where maternal toxicity was not seen, increased external malformations, increased number of runts and inhibition of eye formation were observed in the fetuses (EHC 118 (1991)). Therefore, it was classified in Category 1B.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, peripheral nervous system, kidney, gastrointestinal tract)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	There is very little information limited to this substance, and in humans, there are reports of hemiparesis, generalized muscle stiffness, muscle tremors, acrodynia and coma through the percutaneous treatment of yellow mercury oxide ointment for eczema to infants (CICAD 50 (2003)). There are descriptions that not this substance but metallic mercury or inorganic mercury compounds caused nausea, vomiting, diarrhea, tremors, central nervous system depression, emotional instability and irritability, peripheral neuropathy, gingivitis, stomatitis, vision change, hearing loss and renal impairment in humans (route unknown) (ACGIH (7th, 2001)), and that the causes of death by oral exposures were kidney damage, cardiovascular collapse and severe gastrointestinal disorders and the most common findings are gastrointestinal disorders and renal failure (CICAD 50 (2003)). In experimental animals, neurophysiological effects, electrophysiological effects and effects on the kidney and behaviors were observed (ACGIH (7th, 2001)). Gastrointestinal tract disorders were not judged to be local effects. From the above, it was classified in Category 1 (central nervous system, peripheral nervous system, kidney, gastrointestinal tract).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system, kidney)	Danger	H372	P260 P264 P270 P314 P501	There are no findings of hazards by repeated exposures to this substance in either humans or experimental animals. However, as for findings by repeated exposures to inorganic mercury compounds, in multiple cases in humans who ingested mercury chloride (mainly mercuric chloride) (ATSDR (1999)) and in many studies which rats or mice were dosed orally with mercuric chloride for 2 weeks to 2 years (CICAD 50 (2003)), renal effects (renal failure (humans), nephropathy, tubular epithelial degeneration, glomerular thickening (rats and mice)) were observed. Therefore, the kidney is considered the target organ. In addition, it is described that in several case reports of humans who took drugs containing mercury chloride, CNS symptoms (irritability, sleeplessness, muscle twitching, etc.) were observed, and in chronic poisoning cases, progress of dementia and irritability occurred, and at necropsy of the cases of a small number of deaths, a decrease in the weight and volume of the brain and a decrease in the number of nerve cells in the cerebellum were observed and the accumulation of mercury was confirmed in the neurons by electron microscopic observation (ATSDR (1999)). From the above, it is considered appropriate to classify this substance also in this GHS classification with reference to the hazardous findings of inorganic mercury compounds such as mercury chloride. Therefore, this substance was classified in Category 1 (central nervous system, kidney).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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