Item | Information |
---|---|
CAS RN | 2212-67-1 |
Chemical Name | S-Ethyl hexahydro-1H-azepine-1-carbothioate; Molinate |
Substance ID | m-nite-2212-67-1_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Not classified |
- |
- | - | It was classified as "Not classified" from a flash point of 100 deg C (closed cup) (GESTIS (Access on June 2020)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to liquid substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
[Rationale for the Classification] It was classified in Category 4 from (1) - (6). [Evidence Data] (1) LD50 for rats: 369 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010), GESTIS (Access on June 2020)) (2) LD50 for rats: females: 560 mg/kg, males: 614 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)) (3) LD50 for rats: females: 560.2 mg/kg, males: 613.7 mg/kg (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)) (4) LD50 for rats: males: 584 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)) (5) LD50 for rats: females: 660 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)) (6) LD50 for rats: males: 722 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1) - (3). Besides, the classification result was changed from the previous classification by using new information sources. [Evidence Data] (1) LD50 for rabbits: > 2,000 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)) (2) LD50 for rabbits: 3,540 mg/kg (GESTIS (Access on June 2020)) (3) LD50 for rabbits: > 10,000 mg/kg (HSDB (Access on June 2020)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 4 |
Warning |
H332 | P304+P340 P261 P271 P312 |
[Rationale for the Classification] It was classified in Category 4 from (1). Besides, because an exposure concentration was higher than the saturated vapor pressure concentration (0.06 mg/L), a reference value in the unit of mg/L was applied as mist. [Evidence Data] (1) LC50 for rats (4 hours): females: 1.39 mg/L, males: 2.91 mg/L (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), Japanese Journal of Pesticide Science Vol. 15, No. 1 (Pesticide Science Society of Japan, 1990), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)) (2) Vapor pressure of this substance: 0.0056 mmHg (25 deg C) (HSDB (Access on May 2020)) (converted value for the saturated vapor pressure concentration: 0.06 mg/L) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" (equivalent to Category 3 in UN GHS classification) from (1), (2). [Evidence Data] (1) In a skin irritation test with rabbits, slight irritation was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), Japanese Journal of Pesticide Science Vol. 15, No. 1 (Pesticide Science Society of Japan, 1990)). (2) In a skin irritation test with rabbits by 24-hour occlusive application, slight irritation was observed (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)). [Reference Data, etc.] (3) This substance was not irritating to the skin (EHC 76 (1988)). (4) In a test in which a 1% solution of this substance was applied to the skin of 294 patients with contact dermatitis or non-allergic dermatitis, no irritation or allergic reactions were seen (Environmental Risk Assessment for Chemical Substances vol. 8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
[Rationale for the Classification] It was classified in Category 2A from (1) - (4). The classification result was changed because new data (4) indicating Category 2A were obtained. [Evidence Data] (1) This substance was moderately irritating to the eyes (EHC 76 (1988), HSDB (Access on June 2020)). (2) In an eye irritation test with rabbits, moderate to severe irritation was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (3) In an eye irritation test with rabbits, moderate irritation was found and disappeared after 72 hours (Japanese Journal of Pesticide Science Vol. 15, No. 1 (Pesticide Science Society of Japan, 1990)). (4) In an eye irritation test with rabbits, moderate to severe irritation was seen and completely reversed 11 days after application (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] There were descriptions of (1) - (4), but because the details were unknown, or it was information that could not be used for classification, the classification was not possible. As a result of reviewing obtained data, the classification result was changed. [Reference Data, etc.] (1) In a test in which a 1% solution of this substance was applied to the skin of 294 patients with contact dermatitis or non-allergic dermatitis, no irritation or allergic reactions were seen (Environmental Risk Assessment for Chemical Substances vol. 8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)). (2) It was negative in a skin sensitization test with guinea pigs (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (3) It was negative in a skin sensitization test with guinea pigs (open epicutaneous test) (Japanese Journal of Pesticide Science Vol. 15, No. 1 (Pesticide Science Society of Japan, 1990), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)). (4) It was classified in Skin Sens. 1 (H317) in EU-CLP classification (EU CLP classification (Access on June 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1) - (3). [Evidence Data] (1) As for in vivo, it was reported to be negative in a micronucleus test with mouse bone marrow cells (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)). (2) As for in vitro, it was reported to be weakly positive in a gene mutation test with cultured mammalian cells in the presence of metabolic activation, but it was reported to be negative in other in vitro tests such as a bacterial reverse mutation test, a chromosomal aberration test and a sister chromatid exchange test in cultured mammalian cells (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014), Food sanitation research Vol. 51 No. 1 (Japan Crop Protection Association, 2001)). (3) It is reported that it was considered that this substance did not have genotoxicity that could pose a problem in vivo (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Category 2 |
Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] It was classified in Category 2 from (1) - (3). An investigation was conducted by using new information sources, and the classification result was changed. [Evidence Data] (1) As for classification results by domestic and international organizations, it was classified in S (Suggestive Evidence of Carcinogenicity, but not Sufficient to Assess Human Carcinogenic Potential) by EPA (EPA Annual Cancer Report 2019 (Access on September 2020): classified in 2000), Carc.2 in EU CLP classification (EU CLP classification (Access on May 2020)). (2) In two combined chronic toxicity/carcinogenicity tests by 2-year diet administration of this substance to male and female rats (Wistar and SD), a significant increase in the incidence of interstitial cell tumors of the testis was observed in males in a test with Wistar rats, and a significant increase in the incidence of renal cell adenoma or carcinoma (combined) was observed in males in a test with SD rats. In either test, no tumor formation was found in females (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (3) In a carcinogenicity test by 18-month diet administration of this substance to male and female mice, no treatment-related increase in neoplastic lesions was seen (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] Based on (1) to (3), in which reproductive effects of this substance were shown, and based on (1), in which effects on fertility due to toxicity on the male and female reproductive organs were observed, it was classified in Category 1B. New information sources were used and the classification results were changed from the previous classification. [Evidence Data] (1) In a two-generation reproduction study with rats dosed by feeding, parental male animals showed an increase in the number of abnormal spermatozoa at or above 10 ppm (0.8 to 1.1 mg/kg/day) and a decrease in sperm motility, etc. at 15 ppm (1.3 mg/kg/day); parental female animals showed vacuolation and hypertrophy of interstitial gland cells in the ovaries, diffuse fine fatty degeneration of the zona fasciculata of the adrenal glands, etc. at or above 50 ppm (4.7 to 5.6 mg/kg/day); and in both generations, a decrease in the number of live pups (at birth and during lactation period) was observed in males at 15 ppm (P: 1.3 mg/kg/day, F1: 1.6 mg/kg/day) and in females at 300 ppm (P: 28.8 mg/kg/day, F1: 34.5 mg/kg/day); and in F1 generation, lower successful mating rate, etc. were observed in males at 15 ppm (F1: 1.6 mg/kg/day) and females at 300 ppm (F1: 34.5 mg/kg/day) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (2) In a developmental toxicity study with female rats dosed by gavage on days 6 to 15 of gestation, at a dose (140 mg/kg/day) at which severe maternal toxicity ((1 animal sacrificed in extremis), salivation, reduced body weight gain, a decrease in food consumption, and inhibition of erythrocyte cholinesterase (ChE) activity (20% or higher)) was observed, an increase in the number of resorbed embryos in early and middle gestation periods, a decrease in the number of live fetuses, lower body weight, and increases in external, visceral, and skeletal variations were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (3) In a developmental toxicity study with female rabbits dosed by gavage on days 7 to 19 of gestation, at a dose (200 mg/kg/day) at which severe maternal toxicity (abortions (4 cases), reduced body weight gain, increases in absolute and relative liver weight) was observed, skeletal variations (incomplete ossification of the sternebrae, shortened 15th rib) were observed in fetuses (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). [Reference Data, etc.] (4) In the reproduction study of (1) above, a decrease in sperm motility, lower successful mating rate, etc. were observed in rats. As a result of a mechanism examination test, it was suggested that the mechanism of development of reproductive toxicity in males was inhibition of steroid synthesis due to disorders of cholesterol metabolism (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (5) In the EU CLP classification, it was classified as Repr.2 (Classification in EU CLP (Access on June 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system), Category 2 (reproductive organs (male)), Category 3 (respiratory tract irritation) |
Danger Warning |
H370 H371 H335 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
[Rationale for the Classification] There was no report on acute exposure effects of this substance in humans. Based on (1) to (6), it was classified in Category 1 (nervous system), Category 2 (reproductive organs (male)), and Category 3 (respiratory tract irritation). New information sources were used and the classification results were changed from the previous classification. [Evidence Data] (1) In an acute oral toxicity test with female rats, a decrease in motor activity was observed at or above 200 mg/kg (within the range for Category 1); and sedation, salivation, lacrimation, dyspnea, frequent urination, and subnormal temperature were observed at or above 1,000 mg/kg (within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)). (2) In an acute oral toxicity test with male rats, sedation and frequent urination were observed at or above 464 mg/kg (within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)). (3) In an acute oral toxicity test with male rats, sedation, salivation, and excessive masticatory movement were observed at or above 492 mg/kg (within the range for Category 2); and hypokinesis and lacrimation were observed at or above 1,060 mg/kg (within the range for Category 2). In the rats that died at 1,060 mg/kg, ataxia, intermittent tremors, exudation of blood around the eyes, frequent urination, and lower body temperature were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)). (4) In an acute oral toxicity test with rats, convulsion of the hindlimbs and eye discharge were observed at or above 288 mg/kg (within the range for Category 1), and clonic convulsion or tremor was observed at the time of death (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)). (5) In an acute neurotoxicity test by oral administration to rats, at 350 mg/kg (within the range for Category 2), decreases in body weight and food consumption, inhibition of erythrocyte cholinesterase (ChE) activity, and testicular atrophy were observed in males; and lower body weight, inhibition of brain ChE activity, and necrosis of the brain piriform cortex and dentate gyrus nerve cells (one case) were observed in females (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (6) In a 4-hour acute inhalation exposure test with rats, salivation was observed at or above 0.41 mg/L (within the range for Category 1), lacrimation was observed at 2.59 mg/L (within the range for Category 2), and rhinorrhea was observed at or above 1.09 mg/L (within the range for Category 2). At or above 2.59 mg/L (within the range for Category 2), lower reactivity to sound, increased depth of respiration, a decrease in respiratory frequency, a decrease in reflection response, sedation, a decrease in motor activity, a decrease in respiration rate and increased depth of respiration, tremor, expanded stride, crouching, hypokinesis, and abnormal respiratory sound (slight irritation of the upper respiratory tract) were observed. At the necropsy in males, discoloration and smaller shapes of the testes, renal hypertrophy, and pale kidney were observed. In a histopathological examination, bilateral infarction in the testes and a decrease in sperm count in the epididymis were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, muscle, reproductive organs (male)), Category 2 (adrenal gland, reproductive organs (female)) |
Danger Warning |
H372 H373 |
P260 P264 P270 P314 P501 |
[Rationale for the Classification] Based on (1) to (6), it was classified in Category 1 (nervous system, muscle, reproductive organs (male)), and Category 2 (adrenal gland, reproductive organs (female)). As a result of examination using new information sources, the classification results were changed from the previous classification. [Evidence Data] (1) In a 90-day feeding study with rats, a dose-related increase in neuropathy target esterase (NTE) activity was observed in males and females at or above 50 ppm (males/females: 4.0/4.5 mg/kg/day, within the range for Category 1), and additionally, inhibition of brain and erythrocyte cholinesterase (ChE) activity was observed in females at or above 150 ppm (males/females: 11.7/13.9 mg/kg/day, within the range for Category 2), and inhibition of brain and erythrocyte ChE activity was observed in males at 450 ppm (males/females: 35.5/41.0 mg/kg/day, within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (2) In a 90-day feeding study with rats, degeneration of seminiferous tubular cells and vacuolation of adrenocortical cells were observed in males at or above 70 mg/kg/day (within the range for Category 2), and degenerative changes of the seminiferous tubules with aspermatogenesis in males and atrophy of the ovary and vacuolation of adrenocortical cells in females were observed at 140 mg/kg/day (exceeding Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (3) In a 90-day feeding study with rats, foamy vacuolation of interstitial cells in the ovaries was observed in females at or above 16 mg/kg/day (within the range for Category 2), and an increase in adrenal gland weight and vacuolation of adrenocortical cells were observed in females at 32 mg/kg/day (within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (4) In a combined chronic toxicity/carcinogenicity study with rats, at or above 50 ppm (males/females: 0.21/0.25 mg/kg/day, within the range for Category 1), retinal abnormalities, which were found in an eye examination, and degeneration of skeletal muscle fibers were observed in males and females, and seminiferous tubule atrophy was observed in males; at or above 100 ppm (3.90/5.13 mg/kg/day, within the range for Category 1), localized atrophy of the retina was observed in females; and at 200 ppm (7.90/10.5 mg/kg/day, within the range for Category 1 for males and within the range for Category 2 for females), hyperplasia of satellite cells of the skeletal muscle in males and an increase in absolute ovary weight in females were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (5) In a combined chronic toxicity/carcinogenicity study with rats, at or above 7 ppm (0.3/0.4 mg/kg/day, within the range for Category 1), atrophy and satellite cell hyperplasia of the skeletal muscle were observed in males; at or above 40 ppm (1.8/2.0 mg/kg/day, Category 1), degeneration and demyelination of the sciatic nerve in males and females and atrophy and satellite cell hyperplasia of the skeletal muscle in females were observed; and at 300 ppm (13/15 mg/kg/day, within the range for Category 2), adduction of the hindlimbs, ataxia of the hindlimbs, inhibition of erythrocyte ChE activity, and eosinophilic bodies in the spinal cord in males and females, a decrease in epididymal sperms and degeneration of the spinal cord in males, and vacuolation/hypertrophy of theca/interstitial cells in the ovary, etc. in females were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (6) In a combined chronic toxicity/carcinogenicity study with mice, at or above 100 ppm (10.4/13.9 mg/kg/day, within the range for Category 2), degeneration of seminiferous tubules in the testes was observed in males; at or above 1,000 ppm (105/133 mg/kg/day, exceeding Category 2), decreases in red blood cell count, hemoglobin, and hematocrit, deposition of ceroid or lipofuscin and calcification in the adrenal gland, an increase in eosinophilic bodies in the brain, demyelination, and Schwann cell hyperplasia of the sciatic nerve were observed in males and females, and a decrease in white blood cell count, an increase in eosinophilic bodies in the spinal cord, and hyperplasia of theca/interstitial cells in the ovary were observed in females; and at 2,000 ppm (200/249 mg/kg/day, exceeding Category 2), weakened muscle of the hindlimbs, adduction and ataxia of the hindlimbs, hyperplasia of Clara cells in the lungs, and eosinophilic bodies in the spinal cord were observed in males and females, a decrease in testicular weight and centrilobular hepatocyte hypertrophy were observed in males, and atrophy of the mammary gland and uterus, etc. were observed in females (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 96-hour LC50 = 0.25 mg/L for crustacea (Cypridopsis) (EHC 76, 1988). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
It was classified in Category 2 because it is not rapidly degradable (BIOWIN) and due to 21-day NOEC = 0.32 mg/L for crustacea (Daphnia magna) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2014)). The classification result was revised from the previous classification by changing how to classify it for chronic toxicity. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
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