Item | Information |
---|---|
CAS RN | 22441-45-8 |
Chemical Name | Arsenic pentachloride |
Substance ID | m-nite-22441-45-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Classification not possible |
- |
- | - | It is estimated to be not combustible due to its composition. However, due to lack of test results, classification is not possible. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Liquefied gas |
Warning |
H280 | P410+P403 | At extremely low temperatures (-50degC or so), the substance is presumably stable in a liquid state. Since no information on the critical temperature is available, we cannot determine if the substance is a high-pressure liquefied gas or low-pressure liquefied gas. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | No data available According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride. |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride. |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride. |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available. According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride. |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride. |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No test results are available on this substance. Although inorganic arsenic compounds may cause skin sensitization in humans, this is not a definitive conclusion (ATSDR, 2007; HSG, 1992). According to EHC 224 (2001), dermal sensitization to inorganic arsenic appears to be a rare occurrence in humans. Overall, due to insufficient study results available, the substance was classified into the "classification not possible" category. According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride. |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | No data available. The DFG in Germany has classified arsenic and its inorganic compounds into Category 3A for germ cell mutagenicity (which is equivalent to Category 1B to 2 in the GHS classification) (MAK/BAT, 2007). According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride. |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Category 1A |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
According to IARC Suppl. 7 (1987), ACGIH-TLV (2008), and MAK/BAT (2004), arsenic and its inorganic compounds are categorized as human carcinogens. Thus, the substance was classified into Category 1A. According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride. |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
No test results on this substance were found, but according to description for arsenic and arsenic compounds documented in EHC 224 (2001) which is a List 1 information source, these substances are suggested to affect human reproduction and have teratogenic effects at doses that are toxic to maternal animals. Thus, the substance was classified into Category 2. As additional background information, the Catalog of teratogenic agents (2004), which is equivalent to List 1 sources, supports the conclusion that inorganic arsenic is not teratogenic to humans. According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride. |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Category 1 (gastrointestinal system, circulatory system, nervous system, blood system, respiratory organs, skin, kidney, liver) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
No test results were found on single exposure to this substance other than lethal effects. In humans, the following acute toxic effects by arsenic compounds are documented: symptoms of the gastrointestinal tract, cardiovascular system, nerves, and blood system; conjunctivitis and dermatitis as well as irritation to the nasal mucosa, pharynx, and trachea; frequent urination or anuria due to a blockage of renal tubules with clots of hemoglobin (IARC 23 (1980)); depression of bone marrow functions; and hepatomegaly (EHC 224 (2001)). In accordance with these reports, the digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, and liver were considered to be target organs of these compounds, and this substance was classified into Category 1 (digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, and liver). According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride. |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (gastrointestinal system, circulatory system, nervous system, kidney, liver, blood system, respiratory system, skin) |
Danger |
H372 | P260 P264 P270 P314 P501 |
No test results on repeated exposure to this substance were found. According to EHC 224 (2001) on arsenic and its inorganic compounds in relation to humans, gastrointestinal tract disorder; nervous disorder; effects on the blood system; and abnormalities in cardiovascular system, kidney, and liver were observed. Thus, target organs for these substances are the gastrointestinal tract, heart, brain, and kidney. In addition, the skin, bone marrow and peripheral nervous system are also affected by these substances. Moreover, according to ACGIH (2001), the upper respiratory tract and lung are also affected. Based on these reports, this substance was classified into Category 1 (digestive system, circulatory system, nervous system, kidney, liver, blood system, respiratory system, and skin). According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride. |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride. |
FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
|