Item | Information |
---|---|
CAS RN | 23950-58-5 |
Chemical Name | 3,5-Dichloro-N-(1,1-dimethyl-2-propynyl)benzamide |
Substance ID | m-nite-23950-58-5_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Classification not possible |
- |
- | - | Classification not possible due to lack of data on the kick-off temperature and decomposition energy, though being an acetylene compound containing a triple bond, with its oxygen budget calculated at -178. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Flammable gas | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Flammable solid | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | Classification not possible due to lack of data , though containing a triple bond and chemical groups with self-reactive properties | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is stable to heat (up to 229.1degC) (Agricultural Chemical Registration Data). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | Stable to heat (up to 229.1degC) (Agricultural Chemical Registration Data) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing chlorine and oxygen (but not fluorine), with the chlorine and oxygen bound to carbon and hydrogen (but not to other elements) |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no "-O-O-" structure | FY2006 | GHS Classification Manual (10 Feb, 2006) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 156.2degC (Agricultural Chemical Registration Data)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on the rat LD50 (oral route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1994)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on the rat LD50 (dermal route) value of >3,160mg/kg, together with the absence of mortality (Agricultural Chemical Registration Data (1994)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification cannot be determined, though the available rat inhalation study reported the LC50 value of >2.1mg/L (Agricultural Chemical Registration Data (1994)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | Based on the evidence of irritant effects with a Draize score of <=1, which were fully reversed within 72 hours, observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1994)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | Based on the evidence of conjunctival effects with a Draize score of <=1, which cleared up within 4 days, observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1994)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Skin sensitization | Not classified |
- |
- | - | No skin sensitizing potential was found in guinea pig sensitization tests employing the Buehler and Maximization methods (Agricultural Chemical Registration Data (1993, 1998)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Based on negative data in in vitro studies (reverse mutation tests, chromosome aberration tests and UDS tests) and chromosome aberration tests on rat and mouse bone marrow cells in vivo (Agricultural Chemical Registration Data (1994)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Carcinogenicity | Not classified |
- |
- | - | There was no evidence of treatment-related incidence of tumor formation observed in rat and mouse carcinogenicity studies (Agricultural Chemical Registration Data (1994)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Reproductive toxicity | Not classified |
- |
- | - | Based on no evidence of adverse effects on parental reproduction and offspring development observed in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1994)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Insufficient data available. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver, kidney) |
Warning |
H373 | P260 P314 P501 |
Based on the evidence from animal studies including hyperpigmentation/Glisson capsule abnormalities/cell abnormalities of the liver, degeneration of renal tubular epithelium/glomerular atrophy (Agricultural Chemical Registration Data (1994)). These effects were observed at dosing levels within the guidance value ranges for Category 2. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified in Category 2 from 72-hour EC50 (growth rate) = 3.4 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2018)). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable and 72-hour NOEC (growth rate) = 0.32 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2018)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to being not rapidly degradable, 96-hour LC50 > 9.8 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2018), Environmental Risk Assessment for Chemical Substances Vol. 5 (Ministry of the Environment, 2006)) and water solubility of 15 mg/L (25 deg C, EXP) (PHYSPROP Database (2018)). From the above results, it was classified in Category 2. |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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