NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	2451-62-9
Chemical Name	1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione; Triglycidyl isocyanurate
Substance ID	m-nite-2451-62-9_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	It is described that it is combustible (ICSC (J) (1997)), but the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with self-reactive properties (strained ring) in the molecule, but the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 200 deg C (ICSC (J) (1997)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	There are reports of LD50 values of 188-715 mg/kg (CICAD 8 (1998)) and 255-950 mg/kg (ACGIH (7th, 2001)) for rats, and both data correspond to Category 3-4. It was classified in Category 3 by adopting the category with higher hazard.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the reports of LD50 values for rats of > 2,000 mg/kg (CICAD 8 (1998)) and > 3,100 mg/kg (ACGIH (7th, 2001)), it was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Based on a report of an LC50 value of 0.65 mg/L in a 4-hour inhalation test (dust) with rats (CICAD 8 (1998)), it was classified in Category 3.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Based on a description that in a powder paint manufacturing plant in Australia, irritation such as rash on the skin was observed in 8 of 28 workers handling this substance (NICNAS (1994)), and based on a report that in a skin irritation test with rabbits, this substance showed irritation accompanied with slight erythema and edema (CICAD 8 (1998), ACGIH (7th, 2001), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Based on a description that in a powder paint manufacturing plant in Australia, eye irritation was observed in 8 of 28 workers handling this substance (NICNAS (1994)), and based on a report that in an eye irritation test with rabbits, moderate to severe corneal opacity, erythema and eye discharge occurred, but these resolved within 7 days after an application (NICNAS (1994)), it was classified in Category 2A. Besides, this substance is classified as "Eye Dam. 1" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	It is reported that in 2 cases of workers handling powder paint or pigment powder containing this substance, they did not have atopic diseases before exposure to this substance, however, developed coughing, wheezing, dyspnea, etc. after exposure due to painting work, and these were judged to be occupational asthma due to this substance because of a decrease in forced expiratory volume by the challenge test on this substance (NICNAS (2001)). Therefore, it was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Based on a report that patients who developed contact dermatitis due to occupational exposure showed positive result in a patch test for this substance (ACGIH (7th, 2001), NICNAS (1994)), it was classified in Category 1. Besides, this substance is classified as "Skin Sens. 1" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)). In addition, as for skin sensitization tests with guinea pigs, there are positive reports (CICAD 8 (1998), NICNAS (2001)) and negative reports (NICNAS (2001)) on the skin sensitization of this substance.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Category 1B	Danger	H340	P308+P313 P201 P202 P280 P405 P501	As for in vivo, it was negative in a dominant lethal test with mice, negative in a mouse spot test, positive and negative in chromosomal aberration tests with mouse spermatogonia, negative in a chromosomal aberration test with mouse spermatocytes, positive and negative in sister chromatid exchange tests with Chinese hamster bone marrow cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 8 (1998), ACGIH (7th, 2001)). As for in vitro, it was positive in bacterial reverse mutation tests, a mouse lymphoma test, chromosomal aberration tests and a sister chromatid exchange test with mammalian cultured cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 8 (1998), ACGIH (7th, 2001)). From the above, since reproducibility of the positive results in the chromosomal aberration tests with mouse spermatogonia was confirmed, it was classified in Category 1B according to the GHS classification guidance for the Japanese government.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a report that no increase in the tumors related to administration was observed in the test in which this substance was administered to male rats for a maximum of 99 weeks (10-100 ppm: the test finished at 63 weeks because of occurrence of death cases at the high dose of 300 ppm) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), NICNAS (2001)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a test in which male rats were given this substance by feeding (10-100 ppm) for 9 weeks, then mated with females given normal feed, and the females had deliveries, no effect on male fertility and the development of fetuses and newborns was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), NICNAS (2001), CICAD 8 (1998)). On the other hand, in a test in which male mice were exposed by inhalation to the dust of this substance for 5 days and then mated with non-exposed females for 8 weeks, a depression in male fertility was observed in the third week for those exposed to 10 mg/m3, and in the third and the sixth week for those exposed to 50 mg/m3 (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ACGIH (7th, 2001)). From the above, in the two tests examining male fertility, no effect was observed through the oral route, however, a depression in male fertility was confirmed through the inhalation route. Therefore, because the effect on the male reproductive ability could not be denied, it was classified in Category 2 for this hazard class. Besides, the information source was limited to CICAD in the previous classification, it was expanded in this time, so the classification result was changed.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (hematopoietic system, respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	There are an alpha type and a beta type of this substance, as for humans, alpha-triglycidyl isocyanurate, which is the alpha type, was expected to have an antitumor effect in the 1980s, and intravenous injections to cancer patients were reported, however, development was stopped because thrombophlebitis occurred at the injection region. As for the intravenous injection of alpha-triglycidyl isocyanurate, although the exact administration conditions such as the number of doses were unknown, it is reported that it was dosed with various conditions at up to 900 mg/kg, and that the toxic symptoms such as myelosuppression, nausea and vomiting were observed, and in rare cases, loss of hair and leukopenia were observed at high doses of 600 mg/kg or above (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As for experimental animals, for a 4-hour single inhalation exposure test with dust of this substance, there is a report that slight inflammation of the nasal mucosa, and lung bleeding in dead animals were observed in rats (CICAD 8 (1998)), and there is a report that a decrease in locomotor activity, irritation of the eyes and respiratory organs, crust formation around the nose, eyes and mouth and discoloration of the lung were observed in mice (CICAD 8 (1998)). There are no detailed descriptions of the dose at which these effects were observed, however, it was reported that in these tests, an LC50 value for rats was 0.65 mg/L, which is within the guidance value range for Category 1, and an LC50 value for mice was 2.0 mg/L, which is within the guidance value range for Category 2, therefore, it is considered that the respiratory tract irritation and effects on the respiratory organs were observed in the vicinity of the LC50 values. From the above, it is considered that the target organs of this substance were the hematopoietic system based on the information in humans, and the respiratory organs based on the information in experimental animals. Therefore, it was classified in Category 1 (hematopoietic system, respiratory organs). The classification result was changed from the previous classification by using the new information sources.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (hematopoietic system), Category 2 (systemic)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	There are an alpha type and a beta type of this substance, as for humans, alpha-triglycidyl isocyanurate, which is the alpha type, was expected to have an antitumor effect in the 1980s, and intravenous injections to cancer patients were reported, however, development was stopped because thrombophlebitis occurred at the injection region. As for the intravenous injection of alpha-triglycidyl isocyanurate, it is reported that it was dosed with various conditions at up to 900 mg/kg, and that toxic symptoms such as myelosuppression, nausea and vomiting were observed, and in rare cases, loss of hair and leukopenia were observed at high doses of 600 mg/kg or above (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As for experimental animals, in a 99-week repeated oral dose toxicity test with male rats by feeding, at 300 ppm (13.6 mg/kg/day) within the guidance value range for Category 2, the following is reported: a significant decrease in feed intake, a marked decrease in body weight gain (-68%), deterioration of general conditions, a decrease in the survival rate (56%, other group 90-96%), an increase in mast cells in the mesenteric lymph nodes (44/49), hemosiderin deposition (22/49), sinusoidal bleeding (24/49), a depletion of splenic lymphocyte-like cells, and an expansion of the intestinal tract (duodenum 32/44, jejunum 30/45, ileum 13/36) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). From the above, it was classified in Category 1 (hematopoietic system) based on the results in humans, and it was classified in Category 2 (systemic toxicity) based on the results in experimental animals. The classification result was changed from the previous classification by using the new information sources.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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