Item | Information |
---|---|
CAS RN | 2530-87-2 |
Chemical Name | gamma-Chloropropyltrimethoxysilane |
Substance ID | m-nite-2530-87-2_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It corresponds to Category 3 from a flash point of 45 deg C [closed-cup] (SIDS (2006)) >= 23 deg C and <= 60 deg C. Besides, there are other data: 84 deg C (unknown), 57 deg C (unknown) (SIDS (2006)), but 45 deg C was adopted with safety in mind. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 220 deg C (GESTIS (Access on May 2012)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | There is a metalloid (Si) present in the molecule, but from data on water solubility: 650,000 mg/L (25 deg C) (SIDS (2006)), it is estimated that it does not react vigorously with water. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (Si). However, the classification is not possible due to no data. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" because it is reported that there were no dead animals after administration of 2,000 mg/kg to rats (OECD TG401; GLP), and an LD50 value was > 2,000 mg/kg bw (SIDS (2006)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" because it is reported that there were no dead animals after administration of 2,000 mg/kg to rats (OECD TG401; GLP), and an LD50 value was > 2,000 mg/kg (SIDS (2006)). Besides, as for rabbits, from an LD50 value of 3,595-3,991 mg/kg (SIDS (2006)), it would be "Not classified" in the Classification JIS (Category 5 in UN GHS classification). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Data are lacking. Besides, it is reported that there was no death after 6-hour exposure to the saturated vapour, but the category cannot be determined. Therefore, the classification is not possible. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
It is reported that in a test by a 4-hour semi-occlusive application of 0.5 mL of the undiluted test substance to the skin of six rabbits (OECD TG404, GLP), erythema and edema were observed in three animals each 72 hours after the application, but these disappeared by day 17, the primary dermal irritation index (PII) was 3.23, and it was moderately irritating (SIDS (2006)). Therefore, it was classified in Category 2. Besides, it is reported that no irritation was found in another test by a 4-hour occlusive or semi-occlusive application of 0.5 mL of the undiluted test substance to the rabbit skin, and it was not irritating (SIDS (2006)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
In a test in which 0.1 mL of the undiluted test substance was applied to the rabbit eye (OECD TG405; GLP), one out of three animals showed only minimal conjunctival irritation, and it was judged to be not irritating. On the other hand, in another test in which 0.1 mL of the undiluted test substance was applied to the rabbit eye (in general conformance with OECD TG405 and GLP), slight erythema and edema with discharge were observed within 1 hour after the application but disappeared within 24 hours, and slight iritis was found within 4 hours in two out of six animals, but no corneal injury was seen, and it was judged to be slightly irritating (SIDS (2006)). It was classified in Category 2B as a more hazardous category based on data in the latter test. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Not classified |
- |
- | - | It was classified as "Not classified" because it was assessed to be not sensitizing in a skin sensitization test by a Buehler test with guinea pigs (OECD TG406, GLP) (SIDS (2006)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | It was classified as "Not classified" based on negative results in both a micronucleus test with bone marrow cells after intraperitoneal administration to mice (OECD TG474, GLP) and a micronucleus test with bone marrow cells after 90-day inhalation exposure in rats (SIDS (2006)) as in vivo somatic cell mutagenicity tests. Besides, as for in vitro tests, there is a report on positive results in both an Ames test and a mouse lymphoma test (SIDS (2006)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a one-generation reproductive test with rats by inhalation exposure in males for 28 days from 14 days before mating and females from 14 days before mating throughout the mating and gestation period until 19 days after mating (OECD TG422, GLP), no general toxicity or reproductive toxicity was observed in parent animals even at the highest dose of 100 ppm (SIDS (2006)). However, because data are lacking on effects on the development of offspring including teratogenicity, it was classified as "Classification not possible." | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects) |
Warning |
H336 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
An approximate lethal dose was 10,000 mg/kg in an acute oral administration test with rats, and lethargy and loss of muscle coordination were observed 30 minutes after administration of 5000-10000 mg/kg (SIDS (2006)). And symptoms such as abnormal gait, squatting, and staggering were found up to 6 hours after administration in a test with rats given single oral administration of 2,000 mg/kg (OECD TG401, GLP), but all animals appeared normal after 24 hours (SIDS (2006)). It was classified in Category 3 (narcotic effects) based on the above findings. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (urinary bladder) |
Warning |
H373 | P260 P314 P501 |
In a 90-day repeated inhalation exposure test with rats (vapour, 0.004, 0.041, 0.814, 1.627 mg/L, 6 hours/day), an increased incidence of hyperplasia of the urinary bladder epithelium in males and females and an increased incidence and severity of alpha-2microglobulin (hyaline droplet nephropathy) in the kidney in males were observed at 100 ppm (0.814 mg/L) as exposure effects (SIDS (2006)). Because the exposure concentration (0.814 mg/L) corresponded to the guidance values for Category 2, it was classified in Category 2 (urinary bladder). On the other hand, alpha-2microglobulin nephropathy was not adopted for the rationale because it is a change specific to male rats and does not apply to humans. Besides, an increased incidence of hyperplasia of the urinary bladder epithelium was also found in another test by 28-day repeated inhalation exposure in rats (SIDS (2006)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | It was classified as "Not classified" because toxicity values are >100 mg/L for all of the algae, crustacea, and fish (SIDS, 2006). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (SIDS, 2006), and 72-hour NOEC = 70 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2006). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because it is not water-insoluble (water solubility = 14600 mg/L, PHYSPROP Database 2009), and it corresponds to "Not classified" in acute toxicity for fish (SIDS, 2006). By drawing a comparison between the above results, it was classified as "Not classified." |
FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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