Item | Information |
---|---|
CAS RN | 26447-40-5 |
Chemical Name | methylenediphenyl diisocyanate |
Substance ID | m-nite-26447-40-5_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Its autoignition point is > 600degC (IUCLID 2000), which is higher than 70degC. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140degC) substances are not available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Since its rat LD50 is > 2000 mg/kg (OECD TG 401 GLP) (EU-RAR (2005)) and 31600 mg/kg (male) (CICADs No. 27 (2001)), the substance was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Since its rat LC50 values were 0.369 mg/L for males and 0.380 mg/L for females in 4-hour inhalation tests (EU-RAR 2005 of Final Report), the substance was classified into Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
Since the rabbit Draize tests (OECD TG 406 GLP) resulted that scores for erythema, incrustation and edema peaked on day 7 (EU-RAR (2005)), it is considered to be a late-onset irritating substance. Because the average scores for erythema and incrustation were 2.33 after 72 hours and 3.17 after 7 days (EU-RAR (2005)), it is estimated that the average scores remained between 2.3 and 4.0 for 3 consecutive days. Based on these test results, the substance was classified into Category 2. According to the EU classification, the substance is rated as Xi; R36/37/38. The isomer of this substance, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), is classified into Category 2 (NITE, accessed in February 2009). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
In rabbit tests, 5 out of 6 treated rabbits showed moderate conjunctivitis. While one rabbit who developed conjunctivitis also developed slight corneal epithelial abrasion, 4 other rabbits recovered from conjunctivitis after 6 days; from these results, the substance was concluded to be slightly irritating (EU-RAR (2005)). In addition, in Draize tests using female rabbits (OECD TG 405), the Draize score was 0 for all tested rabbits, concluding that the substance is not irritating (EU-RAR (2005)). These results indicate that the substance is considered to be only a slight irritant, if it is an irritant at all, and it is rated as Xi; R36/37/38 in the EU classification. Thus, the substance was classified into Category 2B. As relevant notes, the isomer of this substance, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), is classified into Category 2A-2B (NITE, accessed in February 2009). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification is not possible due to lack of data. The substance is rated as R42/43 in the EU classification, and its isomer, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), is classified into Category 1 (NITE, accessed in February 2009). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
A maximization tests using female guinea pigs indicate that this substance is a strong allergen (EU-RAR 2005 of Final Report). Furthermore, the substance is rated as R42/43 in the EU classification. Based on this information, the substance was classified into Category 1. As relevant background information, its isomer, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), is classified into Category 1 (NITE, accessed in February 2009). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification is not possible due to lack of data on either in vivo tests or in vitro mutagenicity tests using several indices. Regarding in vitro mutagenicity tests, positive results were acquired in Ames tests (EU-RAR (2005)) (NITE, accessed in February 2009). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | The substance is rated as Carc. Cat. 3; R40 in the EU classification. Since no other classifications have been conducted by different classifying organizations and no tests have been carried out on this substance, it was classified into "Classification not possible". Its isomer, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), is rated as Group 3 by the IARC (IARC 71, 1999), and thus it is classified into "Not classified". (NITE, accessed in February 2009). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. Regarding the isomer of this substance, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), clear reproductive toxicity was not found at the doses that cause general toxicity to parental animals in the tests using pregnant rats that underwent inhalation exposure (IARC 71, 1999; IRIS, 1998; CICAD 27, 2000). Thus, the isomer was classified into "Not classified". (NITE, accessed in February 2009). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | No data available. Regarding the isomer of this substance, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), it is reported to cause respiratory irritation (DFGOT vol. 8, 1997; IARC 71, 1999), and is classified into Category 3 (respiratory tract irritation) (NITE, accessed in February 2009). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In 14-day oral administration tests using rats, no effects of the substance on mortality or changes in body weight were detected at 2000 mg/kg (90-day conversion: 311 mg/kg), which is higher than Category 2 guidance doses (EU-RAR (2005)). However, since there are no reports on other symptoms, blood, biochemical examinations, or presence/absence of pathological cases, the substance was classified into "Classification not possible" due to insufficient data available. With respect to its isomer, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), it has been classified into Category 1 (respiratory system) based on the results of inhalation exposure tests (NITE, accessed in February 2009). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | Since its acute toxicity is > 100 mg/L for either algae, crustaceans or fish (EU RAR, 2005), the substance was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | This substance is known to polymerize after being hydrolyzed, and a polymer is not rapidly degradable and is considered to have low probability of accumulation. According to the GHS manual, this substance is not rapidly degradable (SRC: BioWin V4.10) and its logKow = 4.5 (EU RAR, 2005); in addition, since it is not identified as acutely toxic, it seems appropriate to place the substance into Category 4. However, there is little concern in terms of chronic toxicity since its 21-day NOEC for crustaceans (Daphnia magna) is > 10 mg/L (EU RAR, 2005) and its NOEC for algae and fish are > 1 mg/L; thus, the substance was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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