NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	26471-62-5
Chemical Name	Methyl-1,3-phenylene diisocyanate
Substance ID	m-nite-26471-62-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Containing no atom groups with explosive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified	- -	-	-	The flashing point of 1-methyl-2,4-phenylene-diisocyanate and 1-methyl-2,6-phenylene-diisocyanate is 127degC (ICSC (2004))	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Containing no atom groups with explosive or self-reactive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Not pyrophoric when in contact with air at ordinary temperatures: the flashing point is 620degC (ICSC, 2004) for both 1-methyl-2,4-phenylene-diisocyanate and 1-methyl-2,6-phenylene-diisocyanate	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no "-O-O-" structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Not classified	- -	-	-	Classified into Division 6.1 (UN Recommendations on the Transport of Dangerous Goods, UN#2078)	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	-	- Warning	-	-	Based on the LD50 value of 3,332mg/kg calculated from the testing data of rat LD50 (oral route) of 7,500mg/kg (CERI Hazard Data 97-20, 1998), 5,800mg/kg (NTP TR251, 1986) and 3,060mg/kg (EHC 75, 1987).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the LD50 value of 10,000mg/kg calculated from the testing data of rabbit LD50 (dermal route) of 10,210mg/kg (CERI Hazard Data 97-20, 1998), 19,360 mg/kg (CERI Hazard Data 97-20, 1998) and 10,000mg/kg (EHC 75, 1987).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on the LC50 value (4 hours) of 26ppm, calculated from the testing data of rat LC50 (4 hour inhalation of dust/mist) of 0.099mg/L (CERI Hazard Data 97-20, 1998), 0.355mg/L (CERI Hazard Data 97-20, 1998), 0.34mg/L (EHC 75, 1987) and 0.355mg/L (EHC 75, 1987), was lower than 90% of the saturated vapor concentration (660 ppm) under a saturated vapour pressure of 67 Pa (25degC) (CERI Hazard Data 97-20, 1998), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Based on the following descriptions in DFGOT Vol. 20 (2005) suggesting its irreversible effects, although the substance should be placed in Category 1A from the viewpoint of safety: "on the surface of the skin as well as necrosis and the formation of granulomas (rabbit 24-hour skin irritation tests)" and "undiluted TDI 80/20 was evaluated as caustic. The skin was visibly healing, but the changes were not completely reversible within the follow-up period of 8 and 28days (1- or 4-hour skin irritation tests)".	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Based on the evidence of "irritation and mild damage to the corneal epithelium" in rabbit eye irritation tests (CERI Hazard Data 97-20, 1998), the evidence of "immediate reaction suggestive of pain, lachrymation, swelling of the eyelids, a conjunctival reaction and mild damage to the cornea" (EHC 75, 1987) and the evidence of human health effects found in CERI Hazard Data 97-20 (1998), NTP TR 251 (1986), EHC 75 (1987), DFGOT Vol. 20 (2005) and ACGIH 7th (2004), suggesting irritation with unknown recovery time, although the substance should be placed in Category 2A from the viewpoint of safety.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	Based on the evidence on human health effects from CERI Hazard Data 97-20 (1998), EHC 75 (1987), DFGOT Vol. 20 (2005) and ACGIH 7th (2004) and the fact that the substance is classified as "respiratory sensitizing chemicals" according to the Japanese Society of Occupational Allergy and "Respiratory Tract Group 1" according to Recommendations by the Japan Society of Occupational Health (2005).	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Based on positive results in animal skin sensitization tests reported by CERI Hazard Data 97-20 (1998), EHC 75 (1987) and DFGOT Vol. 20 (2005), the evidence of human health effects from EHC 75 (1987), DFGOT Vol. 20 (2005) and ACGIH 7th (2004) and the fact that the substance is classified as "Skin Group 2" according to Recommendations by the Japan Society of Occupational Health (2005) and "SEN" according to ACGIH-TLV (2005).	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on the absence of data on heritable mutagenicity tests, germ cell mutagenicity tests in vivo, somatic cell genotoxicity tests in vivo and germ cell genotoxicity tests in vivo and negative data on somatic cell mutagenicity tests in vivo (micronucleus tests).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	Due to the fact that the substance is classified as Category A4 by ACGIH (2001), Group 2B by IARC 71 (1999) and Category 2B according to Recommendations by the Japan Society of Occupational Health (2004), and priority was given to the IARC classification, following the guidelines.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Classification not possible	- -	-	-	Insufficient data available. Moreover, although nasal inflammation and relevant changes in the pharynx/trachea and weight loss were observed in the progeny at dosing levels not toxic to the parents (IRIS, 1995), the effects were not significant compared with those on the parents.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs, central nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	Based on the human evidence including "eye/respiratory/skin irritation, severe dry cough, sputum, strangalesthesia, dyspnea, nausea, vomiting, bronchitis associated with severe bronchospasm, pulmonary edema, pneumonia, long-lasting effects on the central nervous system including headache, amnesia, loss of concentration, distraction, personality changes, easy stimulability and depression" (CERI Hazard Data 97-20, 1998), "elation, ataxia, intermittent spasm in extremities, dizziness, loss of consciousness, headache, loss of concentration, memory disorder, confusion, irritability, depression (EHC 75, 1987).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs), Category 2 (liver)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	Based on the human evidence including "throat irritation, dyspnea" (EHC 75, 1987) and the evidence from animal studies including "nasal inflammation, interstitial pneumonia, catarrhal bronchitis, tracheitis, bronchitis and pneumonia associating an increase of fibrous tissues in the bronchiolar wall" (CERI Hazard Data 97-20, 1998) and "pathologic changes in the lung, trachea and liver attributed to test substance administration, bronchial pneumonia, regeneration/deciliation of the bronchial epithelium, fatty liver" (Report by the Ministry of Health, Labour and Welfare, 2001). The effects on the respiratory organs and on the liver of experimental animals were observed at dosing levels within the guidance value ranges for Category 1and Category 2, respectively.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 96h LC50 = 0.358 mg/L for fish (Pagrus major) (Initial Risk Assessment Report, NITE, 2008), it was classified in Category 1.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data were not obtained. From a lack of rapid degradability (a degradation rate by BOD for 2,4-TDI: 0% (the existing chemicals survey program, 2003)), and acute toxicity Category 1, it was classified in Category 1.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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