Item | Information |
---|---|
CAS RN | 26628-22-8 |
Chemical Name | Sodium azide |
Substance ID | m-nite-26628-22-8_v1 |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | The substance is not classified into Class 1 in UNRTDG though it contains chemical groups (azido group) associated with explosive properties present in the molecules. The substance does not fall into "Explosives" also in the Subsidiary risk. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Flammable solids | Classification not possible |
- |
- | - | Classification is not possible since the description in literatures is split over flammability such as "Flammable solids" (Hommel (1996)), "Not flammable" (Weiss (2nd. 1985), HSFS (2008)), "Not considered flammable unless heated above 300 degC" (HSDB (2009)) (SITTIG (5th, 2008)). The substance is not classified into Division 4.1 (Flammable solids, self-reactive substances and soid desensitized explosives) in UNRTDG (UN1687). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | Classified into Type G since the substance is classified into Division 6.1 (Toxic substances), but not into Division 4.1 (Flammable solids) in UNRTDG though there are chemical groups (azido group) associated with explosive properties present in the molecules. The substance had been practically used as the propellant to blow air bags up at the auto collision (ACGIH (2001)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Classified into Not classified since the substance does not burn at room temperature (Patty (5th, 2001)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | The substance is judged to be stable against water from water solubility 41.7 g/100 mL (17 degC) (ICSC (J) (1997)). |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Inorganic compounds containing no oxygen and halogen atoms | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Inorganic compound | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. Information is available that the substance is strongly corrosive to aluminum (HSDB (2009)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 2 |
Danger |
H300 | P301+P310 P264 P270 P321 P330 P405 P501 |
Based on a LD50 value of 45 mg/kg for rats (DFGOT vol. 20 (2003)), the substance was classified into Category 2. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Dermal) | Category 1 |
Danger |
H310 | P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501 |
Based on a LD50 value of 20 mg/kg for rabbits (ACGIH (2001)), the substance was classified into Category 1. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Although a LC50 value was 37 mg/m3 for rats (RTECS (2008)), the exposure period was not clear. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
Based on a report that application to rabbit skin caused corrosion after 4-hour and 3 of 6 rabbits died (DFGOT vol. 20 (2003)), the substance was classified into Category 1. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
Since the substance is classified into Category 1 for skin corrosion, Category 1 was also applied for the eyes. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a positive bacteria reverse mutation test (ACGIH (2001), negative chromosomal aberration tests using human lymphocytes and Chinese hamster ovary cells, and a negative gene mutation test using mouse lymphoma cells (DFGOT vol. 20 (2003)). The strong mutagenic effects of the substance are considered to be specific to bacteria (DFGOT vol. 20 (2003)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
6 | Carcinogenicity | Not classified |
- |
- | - | Based on the classification of "A4" in ACGIH (ACGIH-TLV (2005)), the substance was classified as "Not classified". In a 2-year oral test in rats, body weight gain was decreased dose-dependently and viability was decreased in the high dose group. There was no evidence of carcinogenicity (NTP TR389 (1991)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a test where hamsters were given infusions of the substance from subcutaneously implanted osmotic mini-pumps between days 7 and 9 of gestation, 2/15 dams died. The incidence of early resorptions was significantly higher and encephalocele developed in foetuses (DFGOT vol. 20 (2003)). However, since the results were inadequately documented and the exposure route employed is unconventional, it is not possible to assess prenatal toxicity on the basis of this test (DFGOT vol. 20 (2003)). Classification was not possible. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Specific target organ toxicity - Single exposure | Category 1 (cardiovascular system, lung, central nervous system, systemic) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
The following case reports are available: Accidental poisoning of five laboratory technicians due to ingestion caused pounding of the heart, faintness and myocardial ischemia (NTP TR389 (1991)); Altered mental status, pronounced acidosis, cardiac arrhythmia, decreased cardiac output, and hypotension preceded the death of a chemist who ingested 10 to 20 g of the substance (NTP TR389 (1991)); and A laboratory technician who accidentally ingested a very small amount of the substance was observed to have tachycardia, hyperventilation, and hypotension (HSDB (2009)). In addition, there is a report that the target organ of the substance is the cardiovascular system; it causes dilation of peripheral blood vessels which results in very marked reductions in blood pressure (DFGOT vol. 20 (2003)). Based on the data, the substance was classified into Category 1 (cardiovascular system). In above cases, dizziness, lipothymia, altered mental status, noncardiac pulmonary edema and metabolic acidosis were also observed. In a human suicide case by the ingestion of several grams of the substance, pulmonary edema and brain edema were the finding at autopsy (ACGIH (2001)). Based on the data, the substance was classified into Category 1 (lung, central nervous system, systemic toxicity). In rats, decreased heart rate and generalized convulsions were observed following oral administration (DFGOT vol. 20 (2003)). In rabbits, an oral dose caused reduction in blood pressure and cardiac irregularities (PATTY (5th, 2001)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (central nervous system, cardiovascular system), Category 2 (lung) |
Danger |
H372 | P260 P264 P270 P314 P501 |
In a 13-week repeated oral test with rats, clinical findings at the highest dose (20 mg/kg/day) included lethargy, labored breathing and death. Histopathological lesions were necrosis of the cerebrum and thalamus (NTP TR389 (1991)). In a 2-year repeated oral test with rats, reduced survival was observed at the highest dose (10 mg/kg/day), which was attributed to brain necrosis and cardiovascular collapse induced by exposure to the substance (NTP TR389 (1991)). Based on the data, the substance was classified into Category 1 (central nervous system, cardiovascular system). In addition, in the reported 13-week oral test with rats, congestion, hemorrhage, and edema in the lung were observed in rats receiving 20 mg/kg. Based on this data, the substance was also classified into Category 2 (lung). In a repeated oral dose test in dogs (1 - 10 mg/kg/day), ataxia and histomorphological changes in the cerebrum were observed (HSDB (2009)). In humans, serious adverse effects following exposure are not reported. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
Classified into Category 1 from its 96h-ErC50 = 348 microg/L for algae (Pseudokirchneriella subcapitata) (AQUIRE, 2010). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (Degradation rate by direct measurement (HPLC): 1% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2000)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
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