NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	26952-21-6
Chemical Name	Isooctanol
Substance ID	m-nite-26952-21-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	From a flash point of 82 deg C [open-cup] (HSDB (2009)), it is estimated that it will be > 60 deg C and <= 93 deg C also in the prescribed test method. Therefore, it was classified in Category 4.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 277 deg C (HSDB (2009)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Two LD50 values for rats of 1,480 mg/kg (ACGIH (2001)) and > 2,000 mg/kg (PATTY (5th, 2001)) were reported and corresponded to Category 4 and "Not classified" in the Classification JIS, respectively. It was classified in Category 4 by adopting the category with a higher hazard.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification or "Not classified") based on an LD50 value of > 2,600 mg/kg for rats (ACGIH (2001)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Because no deaths were observed after 6-hour exposure to 200 ppm (saturated vapour) in rats, mice, or guinea pigs (PATTY (5th, 2001)), LC0 was estimated to be 200 ppm (converted 4-hour equivalent value: 245 ppm (1.30 mg/L)), but the category cannot be determined. Therefore, the classification is not possible.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	In tests with rabbits, there are reports on moderate irritation by a 4-hour semi-occlusive application (PATTY (5th, 2001)) and moderate irritation and local necrosis by a 24-hour occlusive application (ACGIH (2001)). And it is reported that an application of the undiluted test substance for 6 to 24 hours produced erythema and edema, and intracutaneous hemorrhages (in some animals), the erythema disappeared within 2-3 days, and the skin became dry and tanned, becoming tough and rigid after 7-10 days. Then, the leathery skin was sloughed (Netherlands assessment document (2003), corresponding to List 2). From the above, an occlusive or semi-occlusive application caused moderate irritation, and local necrosis occurred 4 to 24 hours after the application, but reversibility was observed. Therefore, it was classified in Category 2.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It is reported that in a Draize test by an application to the rabbit eye, persistent and widespread corneal opacity was observed, and it was severely irritating (ACGIH (2001)). And the maximum irritation score observed (equivalent to MMAS or AOI: maximum score possible 110) was 24 on day 1 (Netherlands assessment document (2003)), and the sign cleared within one week (ACGIH (2001)). Therefore, it was classified in Category 2B.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	In a patch test in which undiluted this substance was applied to human volunteers, erythema was observed as primary irritation reactions in 13 out of 32, retesting two weeks later showed mild erythema in all, and reactions intensified in 8 (Netherlands assessment document (2003)), but no conclusion on skin sensitization was drawn from the results. Therefore, it was classified as "Classification not possible."	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In a developmental toxicity test by oral administration to pregnant rats during the organogenesis period, reduced weight gain and decreased food consumption were observed in parent animals at the high dose, but no fetotoxicity or teratogenicity was found (PATTY (5th, 2001)). However, effects on sexual function and fertility of parent animals are unknown due to no data. Therefore, it was classified as "Classification not possible."	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects)	Warning	H371 H335 H336	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	After oral administration to rats and rabbits or dermal administration to rabbits, the principal effects were central nervous system depression, labored respiration, incoordination, ataxic gait, and absent corneal reflexes as well as narcosis (ACGIH (2001), Netherlands assessment document (2003)). Therefore, it was classified in Category 3 (narcotic effects). And it was classified in Category 2 (central nervous system) because deaths occurred together with central nervous system depression after oral administration to rats and rabbits at doses within the guidance value range for Category 2 (300-2,000 mg/kg) (ACGIH (2001), Netherlands assessment document (2003)). On the other hand, as a result of inhalation exposure to 200 ppm in rats, mice, and guinea pigs, no signs of systemic intoxication were observed, but there is a report on irritation of the mucous membranes of the upper respiratory tract (ACGIH (2001)). Therefore, it was classified in Category 3 (respiratory tract irritation).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 2 (upper respiratory tract)	Warning	H373	P260 P314 P501	In a 2-week inhalation exposure test with rats, after the end of an exposure period, all the animals showed nasal epithelial necrosis and squamous cell metaplasia in the high concentration group (3.1 mg/L) and squamous cell metaplasia in the middle concentration group (0.6 mg/L), and these did not fully disappear after a 14-day exposure-free period (Netherlands assessment document (2003)). Therefore, it was classified in Category 2 (upper respiratory tract). Besides, it can be classified in Category 1 judging from the guidance values, but it was classified in Category 2 according to the GHS classification guidance for the Japanese government because data in List 2 alone are available, and its test does not meet Decision criteria 1b3). And there is a description of significant increases in red blood cell parameters indicative of polycythemia in the groups of the middle and high concentrations (Netherlands assessment document (2003)), but it was not used for the rationale for classification because the details on pathological findings, etc. to support it are unknown.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 72-hour EC50 = 12 mg/L for algae (Desmodesmus subspicatus) (AQUIRE, 2012).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	If chronic toxicity data are used, then it is classified as "Not classified" due to no appropriate data obtained on rapid degradability, and 21-day NOEC = 1.6 mg/L for crustacea (Daphnia magna) (AQUIRE, 2012). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 because appropriate data on rapid degradability were not obtained, and it corresponds to Category 3 in acute toxicity for algae (AQUIRE, 2012). From the above results, it was classified in Category 3.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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