NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	27858-07-7
Chemical Name	Octabromobiphenyl (Polybrominated biphenyl)
Substance ID	m-nite-27858-07-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified	- -	-	-	Classified into Class 9 (UN#3152 Polyhalogenated Biphenyls (solid), or Polyhalogenated Terphenyls (solid)) (UN Recommendation on the Transport of Dangerous Goods).	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive or self-reactive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is used as a flame retardant (EHC 152 (1994)). Classified into Class 9 (UN#3152 Polyhalogenated Biphenyls (solid), or Polyhalogenated Terphenyls (solid)) (UN Recommendation on the Transport of Dangerous Goods).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Classified into Class 9 (UN#3152 Polyhalogenated Biphenyls (solid), or Polyhalogenated Terphenyls (solid)) (UN Recommendation on the Transport of Dangerous Goods).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no "-O-O-" structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on the rat LD50 (oral route) value of 2,000mg/kg (EHC 152 (1994)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the rabbit LD50 (dermal route) value of >10,000mg/kg (EHC 152 (1994)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible because the available rat LC50 (inhalation of dust) value of >0.96mg/L (IARC 41 (1987)) is that of the technical mixture and not a fixed value.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Based on the description in the report on dermal studies in rabbits (EHC 152 (1994)): The technical mixtures tested "induced moderate erythematous and slight edematous response."	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Based on the description in the report on rabbit eye irritation tests (EHC 152 (1994)): The technical mixtures tested "produced corneal effects, conjunctival redness and swelling, and a copious discharge. The reactions disappeared within 4 hours."	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Not classified	- -	-	-	Based on two sets of data from guinea pig skin sensitization studies showing no sensitization potential (EHC 152 (1994)). The technical mixtures are thus unlikely to produce weaker responses.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Information on carcinogenicity in humans is limited to (6). Based on the IARC's classification result (1) and test results of (2)-(5), it was classified in Category 1B. The category was revised as the result of reviewing the previous classification due to the revision of the classification in 2016 by IARC. [Evidence Data] (1) It is described in IARC that there is inadequate evidence in experimental animals for Firemaster BP-6 which is one of polybrominated biphenyls (Br 5-7). However, IARC classified the whole PBBs including this substance in Group 2A by stating that there is sufficient evidence for the carcinogenicity of Firemaster FF-1 (CAS: 67774-32-7) in animal tests on the substance, a commercial mixture of FireMaster BP-6 and 2% calcium polysilicate added for anti-caking, and by considering mechanism and so on and similarities to PCB (IARC 107 (2016)). As for classification results by other domestic and international organizations, Japan Society for Occupational Health (JSOH) classified it in Group 2B (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH) 2018)). (2) In a test in which mice were dosed with Firemaster FF-1 by gavage for six months, an increase in hepatocellular carcinoma was observed in males and females after 30 months (NTP TR244 (1983), IARC 107 (2016)). (3) In a test in which mice were dosed with Firemaster FF-1 by diet for two years, an increase in hepatocellular adenoma and carcinoma was observed in males and females. Moreover, after exposure only in the perinatal period in the same protocol, an increase in hepatocellular adenoma and carcinoma was also observed in males and females. After exposure during the perinatal and adult period, increases in hepatocellular adenoma and carcinoma in males and females and thyroid follicular cell adenoma in males were observed (NTP TR398 (1993), IARC 107 (2016)). (4) In a test in which rats were dosed with Firemaster FF-1 by gavage for six months, increases in neoplastic nodules, hepatocellular carcinoma, and cholangiocarcinoma were observed in males and females after 30 months, and mononuclear cell leukemia was also observed in males (NTP TR244 (1983), IARC 107 (2016)). (5) In a test in which rats were dosed with Firemaster FF-1 by diet for two years, an increase in hepatocellular adenoma and carcinoma was observed in males and females. Moreover, after exposure during the perinatal and adult period in the same protocol, increases in mononuclear cell leukemia in males and females and hepatocellular adenoma and carcinoma in females were observed (NTP TR398 (1993), IARC 107 (2016)). [Reference Data, etc.] (6) In a nested case-control study on a cohort of people who were exposed via food contaminated with polybrominated biphenyls (PBB) after the accident in the chemical plant in Michigan, USA, a trend toward increases in lymphoma and cancers of the digestive system are suggested (IARC 107 (2016)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Based on the evidence of abdominal wall dehiscences and skeletal anomalies in the offspring observed in rat teratogenicity studies, described in PATTY (4th, 2000) and EHC 152 (1994) (though no data are available regarding parental toxicity).	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Insufficient data available	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Insufficient data available	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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