NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	2807-30-9
Chemical Name	2-Propoxyethanol
Substance ID	m-nite-2807-30-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Since its flash point reported 57 degC (closed-cup) (ICSC (J) (2003)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	Since its autoignition temperature is 230 degC (HSDB (2003), GESTIS (Access on July. 2010)), it is considered that the substance does not ignite at room temperature.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen which is chemically bonded only to carbon or hydrogen.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on the rat LD50 values of 3089 mg/kg (SIDS (2010), CICAD 67 (2009)) and 4400 mg/kg (CICAD 67 (2009)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	The two LD50 values for rabbits of 900 mg/kg (CICAD 67 (2009)) and 1337 mg/kg (SIDS (2010), CICAD 67 (2009)) were reported. One corresponds to Category 3 and the other corresponds to Category 4. Selecting the category of greater hazard, Category 3 was adopted.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	From the basis on the rat LC50 value of > 2132 ppm/6hrs (> 2612 ppm/4hrs) (SIDS (2010)), category can not be specified. However, based on the mouse LC50 value of 1530 ppm/7hrs (2024 ppm/4hrs) (DFGMAK-Doc 12 (1999)), the substance was classified as Category 3. Since the toxicity value was lower than 90% of saturated vapor pressure concentration (4105 ppmV), the criterion values for gas were adopted.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	In the guinea pig test, occlusive application of maximum 20 mL/kg for 24 hours caused slight irritating, and symptoms were disappearing in a week (SIDS (2010)). The substance was classified as "Not classified" in the JIS classification (corresponding to Category 3 in the UN-GHS classification) because the test was carried out with a large amount of substance and long application time.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	The substance was classified as Category 2A based on the documented case of "moderate to strong irritation" (SIDS (2010)) resulted from the rabbit Draize test that instillation of 0.1mL of the substance caused severe erythema and moderate edema of the conjunctiva, iritis, and corneal opacity, but all symptoms disappeared within 14 days.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Not classified	- -	-	-	No sensitization was reported in the Buehler test using guinea pigs (OECD TG406, GLP-compliant). In the skin sensitization tests using guinea pigs by injection to footpad, no sensitization was reported in one case (OECD TG406, GLP-compliant), and weak positive reaction in one of five animals was reported in the other case (SIDS (2010)). It was concluded that the substance was not sensitized for animals and humans, and not a skin sensitizer for guinea pigs (SIDS (2010)). Based on the information, the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In the developmental toxicity studies using rats and rabbits by inhalation during the organogenetic period, and in the developmental toxicity study in mice by oral administration during the organogenetic period, although decreases of food consumption and body weight gain were observed as maternal general toxicity, there were no teratogenicity and no adverse effects on the development of the offspring containing fetal toxicity for all species, except for increased skeletal variation rate for rats and rabbits (SIDS (2010)). However, since no information was provided regarding sexual functions and fertility of parental animals, the substance was classified as "Classification not possible".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (blood)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	It was reported that the main toxic symptom of this substance was hemoglobinuria caused by hemolytic effect, and that the symptom may occur even at oral doses of 195 mg/kg or lower especially in the rodents (DFGMAK-Doc 12 (1999)). Hematuria was observed in decedents in rats (LD50 value: 3089 mg/kg) and mice (LD50 value: 1337 mg/kg) following oral administration. In the inhalation study in rats exposed by vapors, reddish urine was observed in all animals at concentrations of 1100 ppm/6hrs (5.74 mg/L/4hrs) and greater, and hemoglobin concentration and hematocrit were reduced at all levels tested (250 - 2000 ppm) (SIDS (2010)). Because the effects were observed at 1100 ppm/6hrs (5.74 mg/L/4hrs) and above, corresponding to the level within Category 1 of the guidance values, and gross hemolysis was also observed (SIDS (2010)), the substance was classified as Category 1 (blood).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood)	Warning	H373	P260 P314 P501	It was described that the substance caused hemolysis of the erythrocyte in various species containing rats (PATTY, 5th (2001)). In the 6-week gavage study in rats, the effects were observed at the dose level of 195 mg/kg/day (converted dose level as that of 90-day study: 90 mg/kg/day) or more were as follows: reductions in hemoglobin concentration and erythrocyte count, hematuria and hemosiderin deposition in kidneys (SIDS (2010)). In the 14-week inhalation study in rats exposed to vapor, hemoglobinuria and the findings indicating hemolysis containing reductions in erythrocyte count, hemoglobin concentration and hematocrit values was observed at 200 ppm (0.852 mg/L) and above. As for histopathological findings, pigmentation in the kidneys, liver and spleen (presumably resulting from hemolysis) were observed histopathologically in these higher concentrations (PATTY, 5th (2001)). Based on these findings, because these doses which the effects were seen in both oral and inhalation routes existed within Category 2, the substance was classified as Category 2 (blood).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Classified as "Not classified" since its 96h-LC50 for fish and 48h-EC50 for crustacea are 5000 mg/L or more (SIDS, 2004).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Classified as "Not classified" since its acute toxicity is "Not classified" and it is rapidly degradable (20d-BOD degradation rate: 100% (SIDS, 2004) and LogPow = 0.08 (PHYSPROP Database, 2011)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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