NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	2893-78-9
Chemical Name	1,3-Dichloro-1,3,5-triazine-2,4,6(1H,3H,5H)trione, sodium salt
Substance ID	m-nite-2893-78-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	The substance is not classified into upper class "Explosives" since the substance is classified into Division 5.1, PG II in UNRTDG (UN2465) though it contains chemical groups (N-halogen atoms) associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified	- -	-	-	Not combustible (Weiss (2nd, 1986))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Type G	- -	-	-	Estimated to be classified into Type G since the substance is considered not to fall into upper class "Self-reactive substances and mixtures" from which it is classified into Division 5.1, PG II in UNRTDG (UN2465) though there are chemical groups (N-halogen) present in the molecule associated with explosive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified	- -	-	-	Not combustible (Weiss (2nd, 1986))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (Weiss (2nd, 1986))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	The substance is considered to be stable against water since data are available that water solubility is 30.0 g/100 g (Ullmanns (E) 6th, 2003)) though it contains metals (Na).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Category 2	Danger	H272	P370+P378 P210 P220 P280 P501	The substance is classified into Division 5.1, PG II in UNRTDG (UN2465). It is confirmed that dihydrate (CAS51580-86-0) falls into Not Classified as it is mentioned to be Non-dangerous goods in UNRTDG, Special provisions 135.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on LD50 values of 735 mg/kg, 1823 mg/kg (IUCLID (2000)) and 1670 mg/kg (HSDB (2003)) for rats, the substance was classified into Category 4.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on LD50 values of >5000 mg/kg bw for rats (IUCLID (2000)) and >2000 mg/kg bw for rabbits (IUCLID (2000)), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on a LC50 value of >50 mg/L/1h (12.5 mg/L/4h) for rats (IUCLID (2000)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification). Since the LC50 value (50 mg/L) was higher than saturated vapour pressure concentration (1.7E-13 mg/L), the test was considered to be conducted for dusts.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	In a rabbit test by application to the skin for 24-hour, the test substance was determined to be a non-irritant to intact skin and a moderate to moderately severe irritant to abraded skin (HSDB (2003)). Additionally, it was reported that the substance was "moderate irritating" in another rabbit test (Draize test) (IUCLID (2000)). Based on these results and a report that application to wet skin or application of the solution can cause "severe irritation" (SITTIG (5th, 2008)), the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Application into the conjunctival sac of rabbits at a dose level of 10 mg showed dull irises and corneas, and erythema sufficient to make individual blood vessels not easily discernible within 1-hour. Iris congestion remained until the 7th day. The test substance was determined to be a moderately severe irritant. Additionally, the substance is classified into Xi; R36/37 in EU classification (EU-Annex I (access on Sep. 2009)). Based on these information, the substance was classified into Category 2A.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	A negative result is reported in a bone marrow chromosomal aberration test (in vivo somatic cell mutagenicity test) where rats were orally administered a related substance, monosodium cyanurate (IUCLID (2000)). However in vivo data for this substance is absent. Therefore, classification was not possible. As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (NTP DB (access on Sep. 2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Classification not possible	- -	-	-	Although there is a report that no fetal toxicity was observed when mice were administered orally during organogenesis period (teratogenic (12th, 2007)), classification was not possible due to lack of data for effects on sexual function and fertility of parental animals.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 2 (systemic), Category 3 (respiratory tract irritation)	Warning	H371 H335	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	In a rat acute oral toxicity test (dosage 1450 - 1925 mg/kg, LD50 = 1670 mg/kg), clinical signs including emaciation, weakness, lethargy, diarrhea and necropsy findings such as irritation of the gastrointestinal tract, tissue edema, and liver and kidney congestion were observed (HSDB (2003)). In a rabbit acute oral toxicity test (dosage: 1000 - 3000 mg/kg, minimal lethal dose: 2500 mg/kg), clinical signs including prostration, coma, salivation, lacrimation, labored breathing. Necropsy findings such as liver dysfunction, irritation of the digestive tract, and lung congestion were noted (HSDB (2003)). Based on a report that the oral toxicity is apparently due to corrosive action on the stomach (HSDB (2003)), these findings are considered to be systemic toxicity caused by the strong irritation to the digestive tract. Since death occurred at dose levels within the guidance value range for Category 2 and the affected organ cannot be identified, the substance was classified into Category 2 (systemic toxicity). In addition, based on reports of irritating to the upper respiratory tract, irritating to respiratory system or some bronchospasm as signs in human exposure (HSDB (2003)), the substance was classified into Category 3 (respiratory tract irritation).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Classified into Category 1 from its 48h-EC50 = 0.11 mg/L for Crustacea (Daphnia magna) (AQUIRE, 2010).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (BIOWIN).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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