Item | Information |
---|---|
CAS RN | 2921-88-2 |
Chemical Name | O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) thiophosphate [Chlorpyrifos] |
Substance ID | m-nite-2921-88-2_v1 |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Classification not possible |
- |
- | - | It is described that it is combustible (ICSC (J) (2014)), but the classification is not possible due to no data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains metalloids (P), but it is estimated that it does not react vigorously with water from the measurement data of water solubility of 1.4 mg/L (25 deg C) (HSDB (Access on June 2017)). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | No data available. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | There is no bivalent -O-O- structure in the molecule. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | There is the information that it is a substance with melting point of <= 55 deg C and attacks copper and brass (ICSC (J) (2014)), but the classification is not possible due to no data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
Based on six reports of LD50 values of 82 mg/kg (females) (ATSDR (1997)), 118 mg/kg (males) (ATSDR (1997)), 135 mg/kg (females) (ATSDR (1997), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)), 155 mg/kg (females and males) (ATSDR (1997)), 163 mg/kg (males) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)), and 223 mg/kg (females and males) (EPA Pesticide (2006)), it was classified in Category 3. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | There are two reports of LD50 values for rats of 202 mg/kg (ATSDR (1997), ACGIH (7th, 2003), EPA Pesticide (2006)) and > 2,000 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)). Although one value corresponds to Category 3, and the other corresponds to "Not classified," this substance was classified as "Not classified" by adopting the data from a GLP-compliant test in the Risk Assessment Report by the Food Safety Commission of Japan. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, an LC50 value of 0.2 mg/L for rats was reported (EPA Pesticide (2006), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)). This data might be based on aerosols because this substance is a solid. A category cannot be determined on the basis of this data alone. Therefore, it was classified as "Classification not possible." | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | Based on a report that this substance was slightly irritating in a skin irritation test with rabbits, and the irritation resolved within 7 days (EPA Pesticide (2006), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)), it was classified as "Not classified" (Category 3 in the UN GHS classification). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
Based on a report that this substance was slightly irritating in an eye irritation test with rabbits, and the irritation resolved within 24 hours (EPA Pesticide (2006), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)), this substance was classified in Category 2B. This substance was reclassified on the basis of data newly obtained from this survey. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | It was reported that this substance was not sensitizing in a skin sensitization test with guinea pigs based on the Buehler method (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)). However, since only one case is reported, this substance was classified as "Classification not possible," and the category was revised. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese Government. As for in vivo, there are reports of negative and positive results from mouse bone marrow cell micronucleus tests (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011), ATSDR (1997)), but reproducibility of the positive finding has not been established. As for in vitro data, a bacterial reverse mutation test and a chromosomal aberration test and a sister chromatid exchange test with mammalian cultured cells were all negative (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011), ATSDR (1997), NTP DB (Access on May 2017)). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No carcinogenicity was observed in either a 2-year feeding study with rats, an 18-month feeding study with mice, or a 2-year feeding study with mice (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)). As for classifications by other organizations, this substance was classified by the ACGIH in A4 (ACGIH (7th, 2003), proposed in 1995) and by the EPA in Group E (Evidence of Non-Carcinogenicity for Humans) (Chemicals Evaluated for Carcinogenic Potential: Annual Cancer Report (2016), evaluated in 1993). From the above, in accordance with the GHS classification guidance for the Japanese government, this substance was classified as "Classification not possible" on the basis of the classification result by the ACGIH, which proposed a carcinogenic classification more recently. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a two-generation study with rats dosed by feeding, inhibition of erythrocyte cholinesterase activity was found in the parental animals at or above 1 mg/kg/day, but no adverse effects on reproduction in the parental animals were observed at up to the highest dose of 5 mg/kg/day. However, in the pups, a decrease in the survival rate and reduced body-weight gain were observed at 5 mg/kg/day (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011), PATTY (6th, 2012), ACGIH (7th, 2003)). Meanwhile, in developmental toxicity tests in which pregnant rats, pregnant mice, or pregnant rabbits were dosed by gavage during the organogenesis period, reduced body-weight gain was observed in the dams at 15 mg/kg/day for rats, at 10 mg/kg/day for mice, and at 140 mg/kg/day for rabbits. However, effects on the fetuses were limited: there were either no effects or only minor findings related to reduced body weights, even at maternally toxic doses or above (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011), PATTY (6th, 2012), ACGIH (7th, 2003)). In another study, pregnant rats were dosed by gavage (from days 6-20 of pregnancy) to examine effects on the development of the nervous system in offspring. While erythrocyte cholinesterase inhibition occurred in the dams at or above 0.3 mg/kg/day, the pups showed only effects of reduced body weight but no developmental neurotoxicity at 5.0 mg/kg/day (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)). From the above, clear reproductive/developmental effects which should be adopted as rationale for classification were generally not observed, even at parentally toxic doses, but in the two-generation study with rats, a reduced survival rate of pups was observed even at 5 mg/kg/day, which was the highest dose but is still a rather low dose. In addition, it was considered that information was lacking on whether reproductive/developmental effects occurred when higher doses were administered. Therefore, this substance was classified as "Classification not possible." | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
This substance is an organophosphorus insecticide and inhibits acetylcholinesterase (ATSDR (1997), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)). In humans, multiple cases were reported which showed coma, seizure-like motor activity, miosis, muscle spasms and fasciculation, hyperreflexia or hyporeflexia, lacrimation, salivation, sweating, bronchorrhea, and athetosis by acute oral exposure to this substance by accident or attempted suicide (ATSDR (1997)). As for symptoms of acute inhalation exposure in humans, paresthesia, dizziness, and headache are reported (ATSDR (1997)). As for experimental animals, in tests with rats given single oral doses of 60-100 mg/kg, which correspond to Category 1, it is reported that hypoactivity, ataxia, tremors, and hypothermia were observed, and that brain, plasma, and erythrocyte cholinesterase activities were reduced (ACGIH (7th, 2003)). From the above, this substance was classified in Category 1 (nervous system). |
FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, adrenal gland), Category 2 (eye, blood system, liver) |
Danger Warning |
H372 H373 |
P260 P264 P270 P314 P501 |
In humans, blurred vision, flushing of the skin, and decreased urination were reported among pet-control employees who used this substance within 3 months; fatigue, dizziness, difficulty in concentrating, memory problems, depression, and headache were reported among workers who applied termiticide of this substance and were exposed for an average of 0.4 years (PATTY (6th, 2012)). As for experimental animals, 90-day repeated oral dose toxicity tests with rats or mice dosed by feeding were conducted. The rats exhibited the following: inhibition of erythrocyte cholinesterase activity (20% or more) at or above 1.0 mg/kg/day, which is within the guidance value range for Category 1; inhibition of brain cholinesterase activity and vacuolization in the zona fasciculata in the adrenal gland at or above 5.0 mg/kg/day; and decreases in erythrocyte count, hematocrit values, etc. at 15 mg/kg/day, which is within the guidance value range for Category 2. The mice exhibited inhibition of brain cholinesterase activity at or above 50 ppm (7.5 mg/kg/day), which is within the guidance value range for Category 1; adrenal fatty pigmentation at or above 200 ppm (30 mg/kg/day), which is within the guidance value range for Category 2; and increased mortality, opacity of the eyeball, and acute or subacute keratitis at or above 400 ppm (60 mg/kg/day) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)). In addition, it is reported that in a two-year repeated oral dose toxicity test with rats dosed by feeding, inhibition of erythrocyte cholinesterase activity was observed at or above 1.0 mg/kg/day, which is within the guidance value range for Category 1. Decreases in total cholesterol, total protein, and globulin; inhibition of brain cholinesterase activity; and fatty vacuolization in the zona fasciculata of the adrenal cortex, etc. were observed at 10 mg/kg/day. In an 18-month repeated oral dose toxicity test with mice dosed by feeding, inhibition of erythrocyte and brain cholinesterase activities were found at or above 50ppm (males: 6.1-12 mg/kg/day, females: 6.6-12 mg/kg/day), which is within the guidance value range for Category 1 or near the upper bound thereof. Opacity of the eyeball; salivation; and mild subacute cholangitis, histiocytic hyperplasia, and centrilobular hepatocyte fatty vacuolization in the liver were observed at 250 ppm, which is within the guidance value range for Category 2 (males: 32-55 mg/kg/day, females: 34-62 mg/kg/day) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)). From the above, this substance was classified in Category 1 (nervous system, adrenal gland), Category 2 (eye, haemal system, liver). Classification based on a new information source resulted in a change in the classification result. |
FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
From 48-hour LC50 = 0.000035 mg/L for crustacea (Daphnia ambigua) (Environmental Risk Assessment for Chemical Substances vol. 8 (Ministry of the Environment, 2010)), it was classified in Category 1. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Due to being not rapidly degradable (non-biodegradable, a degradation rate by BOD: 0.2% (J-CHECK, 1979)), and 32-day NOEC (reproduction inhibition) = 0.000045 mg/L for crustacea (Ceriodaphnia cf. dubia) (Environmental Risk Assessment for Chemical Substances vol. 8 (Ministry of the Environment, 2010)), it was classified in Category 1. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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