Item | Information |
---|---|
CAS RN | 298-00-0 |
Chemical Name | Dimethyl-p-nitrophenylthiophosphate; Methylparathion |
Substance ID | m-nite-298-00-0_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | There is a chemical group associated with explosive properties, a nitro group, present in the molecule, but because it is classified in Division 6.1 in UNRTDG (UN2783), and it does not correspond to explosives, hazards of the highest precedence, it was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. Besides, data used in the previous classification was changed in ICSC (2005), which describes that it is combustible. Therefore, the category was revised. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a nitro group, a chemical group associated with explosive properties, and self-reactive atomic groups (P-O), in the molecule, but because it is classified in Division 6.1 in UNRTDG (UN2783), and it is considered to be not applicable to self-reactive substances and mixtures, hazards of the highest precedence, it was classified in Type G. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Because it is classified in Division 6.1, PG II in UNRTDG (UN2783), and it does not correspond to pyrophoric substances, hazards of the highest precedence, it was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains a metalloid (P), but it was classified as "Not classified" because it is estimated that it does not react vigorously with water from water solubility data of 37.7 mg/L (20 deg C) (HSDB (Access on May 2020)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to elements other than carbon and hydrogen (P and N), but no data are available, and the classification is not possible. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified |
- |
- | - | There is a chemical group associated with explosive properties (nitro group) present in the molecule, but this substance was classified as "Not classified" for desensitized explosives because a pure substance does not correspond to any hazard class in explosives. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 1 |
Danger |
H300 | P301+P310 P264 P270 P321 P330 P405 P501 |
[Rationale for the Classification] It was classified in Category 1 from (1) - (12). Besides, there were data in fasted and non-fasted conditions for this substance, and by prioritizing the knowledge in fasting before dosing, required by OECD TG 423, it was classified in Category 1. Therefore, the classification result was changed from the previous classification. [Evidence Data] (1) LD50 for rats: males: 2.9 mg/kg, females: 3.2 mg/kg (EHC 145 (1993)) (2) LD50 for rats: 4.5-24 mg/kg (EPA Pesticides RED (2006)) (3) LD50 for rats: 4-62 mg/kg (JMPR (1995)) (4) LD50 for rats: 6 mg/kg (EHC 145 (1993)) (5) LD50 for rats: 7.4 mg/kg (EHC 145 (1993)) (6) LD50 for rats: females: 9.3 mg/kg, males: 10.8 mg/kg (EHC 145 (1993)) (7) LD50 for rats: males: 11 mg/kg, females: 16 mg/kg (NTP TR157 (1979)) (8) LD50 for rats: males: 11.7 mg/kg (EHC 145 (1993)) (9) LD50 for rats: 14 mg/kg (IPCS PIM G001 (1998)) (10) LD50 for rats: males: 14 mg/kg, females: 24 mg/kg (EHC 145 (1993), HSDB (Access on May 2020), Patty (6th, 2012)) (11) LD50 for rats: 14-24 mg/kg (ACGIH (7th, 2009)) (12) LD50 for rats: 35 mg/kg (EHC 145 (1993)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Category 1 |
Danger |
H310 | P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501 |
[Rationale for the Classification] It was classified in Category 1 from (1) - (8). Besides, by reviewing information, the classification result was changed from the previous classification. [Evidence Data] (1) LD50 for rats: 6 mg/kg (EPA Pesticides RED (2006)) (2) LD50 for rats: 6-67 mg/kg (Patty (6th, 2012)) (3) LD50 for rats: females: 44 mg/kg, males: 46 mg/kg (EHC 145 (1993)) (4) LD50 for rats: 63 mg/kg (EHC 145 (1993)) (5) LD50 for rats: 67 mg/kg (ACGIH (7th, 2009), EHC 145 (1993), ATSDR (2001)) (6) LD50 for rats: males: 110 mg/kg, females: 120 mg/kg (ATSDR (2001)) (7) LD50 for rabbits: 300 mg/kg (EHC 145 (1993), GESTIS (Access on May 2020)) (8) LD50 for rats: 480 mg/kg (JMPR (1995)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
[Rationale for the Classification] It was classified in Category 1 from (1) - (5). By reviewing information, the classification result was changed from the previous classification. Besides, because exposure concentrations were higher than the saturated vapor pressure concentration (5.0E-005 mg/L), a reference value in the unit of mg/L was applied as dust. [Evidence Data] (1) LC50 for rats (4 hours): 0.034 mg/L (US AEGL (1987), GESTIS (Access on May 2020), HSDB (Access on May 2020)) (2) LC50 for rats (4 hours): 0.034-0.185 mg/L (US AEGL (1987)) (3) LC50 for rats (4 hours): 0.12 mg/L (EHC 145 (1993), US AEGL (1987), Patty (6th, 2012)) (4) LC50 for rats (4 hours): 0.13 mg/L (JMPR (1995)) (5) LC50 for rats (4 hours): females: 0.17 mg/L, males: 0.185 mg/L (EHC 145 (1993)) (6) Vapor pressure of this substance: 3.5E-006 mmHg (25 deg C) (HSDB (Access on May 2020)) (converted value for the saturated vapor pressure concentration: 5.0E-005 mg/L) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1) - (6). The classification result was changed due to new data obtained. [Evidence Data] (1) This substance (technical grade) did not irritate the skin and eye (EHC 145 (1993)). (2) As a result of 4-hour or 6-hour application of this substance to the rabbit skin at up to the lethal dose (LD100), no irritation was shown (EHC 145 (1993)). (3) It was not irritating in a skin irritation test with rabbits according to OECD TG 404 (EHC 145 (1993)). (4) It was slightly irritating to the skin in rabbits (JMPR (1995)). (5) In a skin irritation test with rabbits according to EPA OPPTS 870.2500, the maximum score was 2, and the score after 72 hours was 0.5 (EPA Pesticides (2006)). (6) This substance is not irritating to the skin and eye (GESTIS (Access on May 2020)). [Reference Data, etc.] (7) In a skin irritation test by 1 to 24-hour semi-occlusive application of a formulation containing 80% of this substance to the rabbit skin, very minor to moderate reddening was seen at 1 hour after the application (GESTIS (Access on May 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
[Rationale for the Classification] It was classified in Category 2B from (1), (2). [Evidence Data] (1) It was slightly irritating to the eyes in rabbits (JMPR (1995)). (2) in an eye irritation test with rabbits according to EPA OPPTS 870.2400, irritation reactions cleared by 7 days (EPA Pesticides (2006)). [Reference Data, etc.] (3) It was not irritating in an eye irritation test with rabbits according to OECD TG 405 (EHC 145 (1993)). (4) In an eye irritation test in which a formulation containing 80% of this substance was applied to the rabbit eye, only slight reddening was seen at 1 hour after the application, which was reversible within 48 hours (GESTIS (Access on May 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1) - (3). [Evidence Data] (1) It was not sensitizing to the skin in guinea pigs (JMPR (1995)). (2) It was not sensitizing in a skin sensitization test with guinea pigs according to EPA OPPTS 870.2600 (EPA Pesticides RED (2006)). (3) No skin sensitizing effects were confirmed in humans or animals for this substance (GESTIS (Access on May 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] It was classified in Category 2 from (1) - (3). [Evidence Data] (1) As for in vivo, it is reported that it was negative in a dominant lethal test with mice but positive and negative in chromosomal aberration tests using rats/mice, micronucleus tests using rats/mice, and unscheduled DNA synthesis tests using bone marrow cells or reproductive cells of mice (ATSDR (2001), EHC 145 (1993), ACGIH (7th, 2009), IARC 30 (1983)). (2) As for in vitro, it is reported that it was positive and negative in bacterial reverse mutation tests and chromosomal aberration tests with cultured mammalian cells, positive in a sister chromatid exchange test with cultured mammalian cells, and negative in an unscheduled DNA synthesis test with cultured human-derived cells (ATSDR (2001), EHC 145 (1993), ACGIH (7th, 2009), IARC 30 (1983), CEBS (Access on May 2020)). (3) An increase in chromosomal aberrations was reported in peripheral blood lymphocytes from workers exposed to this substance (ATSDR (2001), EHC145 (1993)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Not classified |
- |
- | - | [Rationale for the Classification] There was no available report in humans. It was classified as "Not classified" from (1), (2). [Evidence Data] (1) As for classification results by domestic and international organizations, it was classified Group 3 by IARC (IARC Sup7 (1987)), A4 by ACGIH (ACGIH (7th, 2009)), and NL (Not Likely to be Carcinogenic to Humans) by EPA (EPA Annual Cancer Report 2019 (Access on July 2020): classified in 1997). (2) In carcinogenicity tests by 2-year diet administration of this substance to male and female rats and mice, no significant increase in tumor incidences was observed in either species, and it was concluded that this substance was not carcinogenic in rats and mice (NTP TR157 (1979)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] In (1), at a dose at which parental toxicity was unknown, clear effects were observed in pups. In (2) and (3), the degree of developmental effects at a dose at which maternal toxicity was observed was not clear or could not be adopted as rationale for the classification. Therefore, it was classified in Category 2 in accordance with the GHS Classification Guidance for the Japanese Government. [Evidence Data] (1) In a three-generation reproduction toxicity study with rats, there was no description of toxicity in parental animals, but a decrease in litter size, lower survival rate, etc. were observed (EHC 145 (1993)). (2) In a developmental toxicity study with female rats dosed by gavage on days 6 to 15 of gestation, at a dose at which mortality, abnormalities in general conditions, a decrease in body weight, and inhibition of cholinesterase (plasma, erythrocyte, brain) activities were observed in dams, increases in post implantation embryo loss and embryo resorption, a decrease in fetal body weight, and delayed ossification were observed (ACGIH (7th, 2009)). For the data that appeared to be obtained in the same study, the JMPR (1995) described only delayed ossification as an effect on fetuses and did not indicate effects such as increases in post implantation embryo loss and embryo resorption. (3) In a developmental toxicity study with female rats dosed by gavage on days 6 to 15 of gestation, at a dose at which reduced body weight gain was observed in dams, slight growth retardation in embryos and fetuses was observed (EHC 145 (1993)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, cardiovascular system, respiratory organs) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
[Rationale for the Classification] Based on (1) to (5), it was classified in Category 1 (nervous system, cardiovascular system, respiratory organs). Based on the ATSDR (2001), effects on the liver were non-specific associated with hypoxia, stress, etc. and effects on the kidney were also considered to be secondary effects of hypoxia. Therefore, they were not adopted as rationale for the classification. A new information source was used and the classification results were changed from the previous classification. [Evidence Data] (1) As a result of inappropriate indoor use of this substance as an insecticide, seven children exposed to this substance showed signs of organophosphate poisoning (lethargy, increased salivation, increased respiratory secretions, pinpoint pupils, respiratory arrest) (ACGIH (7th, 2009), ATSDR (2001)). (2) As symptoms of poisoning in humans acutely exposed to this substance (oral, dermal, inhalation), respiratory, cardiovascular, hepatic, and renal effects were observed (ATSDR (2001)). (3) Pulmonary edema was reported in humans who died from acute intoxication with this substance. Primary muscarinic effects of this substance are bronchoconstriction and hypersecretion of bronchial glands (bronchorrhea), and bronchoconstriction, bronchorrhea, and bradycardia caused by this substance are strongly conducive to pulmonary edema (ATSDR (2001)). (4) Acute exposure to this substance resulted in 30 fatalities, 20 men and 10 women, aged 18 to 82, within 2 hours to 9 days after exposure. Of the 30 cases, 26 had ingested 50 to 300 g of this substance, while the rest had a combination of excessive dermal and inhalation exposure during spraying. Histological lesions in the liver, kidney, spleen, heart, brain, and vascular endothelium were reported (ATSDR (2001)). (5) Signs and symptoms of acute intoxication with this substance were characteristic of systemic poisoning by cholinesterase-inhibiting organophosphorous compounds. They included peripheral and central cholinergic nervous system manifestions appearing as rapidly as a few minutes after exposure (EHC 145 (1993)). [Reference Data, etc.] (6) Organophosphorus pesticides such as this substance are absorbed by all routes, including inhalation, ingestion, and dermal absorption. The toxicological effects of the organophosphorus pesticides are due to the inhibition of acetylcholinesterase in the nervous system, resulting in respiratory, myocardial, and neuromuscular transmission impairment (IPCS PIM G001 (1998)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
[Rationale for the Classification] Based on (1) to (6), effects on the nervous system at doses within the range for Category 1 were observed. Therefore, it was classified in Category 1 (nervous system). [Evidence Data] (1) In a 90-day feeding test with rats, decreases in plasma, erythrocyte, and brain cholinesterase (ChE) activities were observed at 25 ppm (1.2 mg/kg/day, within the range for Category 1) (JMPR (1995)). (2) In a 13-week feeding test with dogs, decreases in plasma, erythrocyte, and brain ChE activities were observed at 3 ppm (within the range for Category 1) (JMPR (1995)). (3) In a one-year feeding test with rats, degenerative changes and demyelination of the sciatic nerve were observed at or above 12 ppm (0.5 mg/kg/day, within the range for Category 1) (JMPR (1995)). (4) In a two-year feeding test with mice, decreases in plasma, erythrocyte, and brain ChE activities were observed at 50 ppm (9.2 mg/kg/day, within the range for Category 1) (JMPR (1995)). (5) In a two-year feeding test with rats, tremors, stained fur around the urinary organs, a decrease in body weight, retinal degeneration, sciatic nerve degeneration, decreases in packed cell volume and haemoglobin and erythrocyte counts, and a decrease in brain ChE activities were observed at 50 ppm (2.5 mg/kg/day, within the range for Category 1) (JMPR (1995)). (6) In a two-year feeding test with rats, a decrease in brain ChE activities was observed at 10 ppm (0.52 mg/kg/day, within the range for Category 1) (JMPR (1995)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 48-hour LC50 = 0.00014 mg/L for crustacea (Daphnia magna) (EHC 145, 1992). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
It was classified in Category 1 because it is not rapidly degradable (BIOWIN) and due to 21-day NOEC = 0.00011 mg/L for crustacea (Mysidopsis bahia) (EPA RED, 2006). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
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