NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	306-83-2
Chemical Name	Ethane, 2,2-dichloro-1,1,1-trifluoro-
Substance ID	m-nite-306-83-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified	- -	-	-	Non-combustible, Flash point: none (Non-hazardrous Substance) (Solvent Pocket Book, 1997), Limits of flammability: Non-flammable (PATTY, 5th, 2001)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Nonflammable and no flash point (non-dangerous object) (pocket book books (1997)). Limits of flammability: Nonflammable (PATTY (5th, 2001))	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	With nonflammable and no flash point (non-dangerous object) (solvent pocket book (1997)). Limits of flammability: Nonflammable (PATTY(5th, 2001))	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing chlorine and fluorine (but not oxygen) and these elements are chemically bonded only to carbon (but not to other elements).	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gas substances are not available. Boiling point: 27.6degC (NICNAS, 1996)	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Since the minimum lethal doses was presumed to be 9000 mg/kg by the rat (NICNAS (1999)), it was set as the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Since mortality was not observed in rat and rabbit at 2000mg/kg (NICNAS (1999)), it was set as the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Not classified	- -	-	-	Rat LC50 (4-hour exposure value) = 35000, 32000ppm (NICNAS (1999)). Since all LC50 values far exceed (by 6 - 7 fold) the cut-off value of Category 4, it was classified as out of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Not classified	- -	-	-	As a result of the skin irritation study on rabbits under the OECD Guidelines, there was no erythema and dropsy, and skin irritation was not found (NICNAS (1999)), therefore, it was classified as out of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Although mild to moderate conjunctival irritation and mild corneal clouding are mainly observed by applying concentrate solution of this material or 50% solution to rabbit eye (NICNAS (1999)), it recovered completely within three to seven days (EHC 123 (1992)). So it was set as Category 2B.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Not classified	- -	-	-	Classified as out of category because the skin sensitization test using guinea pigs found no skin sensitization as intradermal injection after sensitization treatment induced no allergic reactions (NICNAS (1999)).	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	The substance was regarded as outside the categories because the results of the chromosome aberration test using rat lymphocytes and the micronucleus test using mouse erythrocytes (both are in vivo mutagenicity tests) are negative.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Classification not possible	- -	-	-	In two years inhalation study to rats, there was no generating of malignant tumor considered to be originated in exposure. But significant or dose dependent increases of hepatic adenoma, bile duct fibroid tumor, leydig cell adenoma, and acinar cell adenoma of pancreas were observed (NICNAS (1999)). However, except for the classification (3B) by DFG, the classification of other evaluation organizations was not made. So it was determined "It cannot be classified."	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Not classified	- -	-	-	There is no effect on survival and generation of the child with organogenetic period exposure in rats and rabbits (NICNAS (1999), ECETOC JACC (2005)). The effects to reproductive functions or potential are not observed in rat two-generatioin exposure test (since pre-mating period to pregnancy and lactation period of F0, since pre-mating to pregnancy and lactation period of F1) (NICNAS (1999)). Moreover, although a metabolite is detected in milk or newborn blood with peripatum exposure in rat and ape, effects on lactation is not observed, either (NICNAS (1999)). As mentioned above, it was out of the Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, liver), Category 2 (heart)	Danger Warning	H370 H371	P308+P311 P260 P264 P270 P321 P405 P501	Central symptoms, such as dizziness and headaches are reported to 40 laborers who received exposure of this product by exploded industrial cooler (NICNAS (1999)). Moreover, there is the report that the workers engaged in dry cleaning received exposure of the solvent including the this product and hepatic function test results rose, and showing the symptoms of acute hepatitis (virus infection is negated) (ECETOC JACC (2005)). It was classified into Category 1 (the central nervous system, liver) based on these results. In addition, for the effects to the liver, liver function tests raised, liver degeneration, and hepatic necrosis are observed in inhalation single exposure in guinea pig (NICNAS (1999)). On the other hand, there is the example of report of developed coronary artery diseases in the human to whom fluorocarbon was exposed (HSDB (2003)), and cardiac inadequacy as short-term exposure effects was decribed in ICSC (1998). The test result that adrenergic hypersensitivity is caused to the heart by exposure of this product in dog is obtained (NICNAS (1999)). It was classified into Category 2 (heart) based on these results.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver)	Danger	H372	P260 P264 P270 P314 P501	Based on the many reports that the liver function test value was elevated or hepatic disorder was affected by occupational repeated exposure, it was classified into Category 1 (liver) (NICNAS (1999), ECETOC JACC (2005)). In addition, when a repeated dose is carried out to animals for two to 13 weeks, the toxic effects on the liver is also observed (NICNAS (1999)), but it is restricted to high levels of exposure over the range of the guidance value.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	Insufficient data available.	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	It was classified into Category 3 from 48-hour EC50=17mg/L of Crustacea (Daphnia magna), and others (CICAD23, 2000).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	Classified into Category 3, since acute toxicity was Category 3 and not rapidly degrading (BOD: 6% (existing chemical safety inspections data)), though less bio-accumulative (BCF=36 (existing chemical safety inspections data)).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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