NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	32536-52-0
Chemical Name	Octabromodiphenyl ether
Substance ID	m-nite-32536-52-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified	- -	-	-	Because this substance was judged as an incombustible substance from the information that it is "Not combustible" (ICSC (2008)), use as "a flame retardant" (15911 chemical products (2011)), and the information that "flame retardants and fire preventing agents" (IUCLID (2000)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified	- -	-	-	Because this substance was judged as an incombustible substance from the information that it is "Not combustible" (ICSC (2008)), use as "a flame retardant" (15911 chemical products (2011)), and the information that "flame retardants and fire preventing agents" (IUCLID (2000)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Because this substance was judged as an incombustible substance from the information that it is "Not combustible" (ICSC (2008)), use as "a flame retardant" (15911 chemical products (2011)), and the information that "flame retardants and fire preventing agents" (IUCLID (2000)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	An organic compound contains oxygen and bromine which are not chemically bonded to elements other than carbon.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No established test method suitable for solid substances.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	All of 4 LD50 values for rats (>28000 mg/kg, >10000 mg/kg, > 5000 mg/kg, >5000 mg/kg) (EU-RAR (2003)) correspond to "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	From no death by a dose of 2000 mg/kg in rabbits and an LD50 value of >2000 mg/kg (EU-RAR (2003)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	From an LD50 value of >15 mg/L/4h (dust) for rats (EU-RAR (2003)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	Because slight erythema (grade 1) in 3 animals and very slight edema (grade 1) in 2 animals indicated 24 hours after application disappeared after 72 hours (EU-RAR (2003)) as a result of a test applied 500 mg of the test substance to skins of 6 rabbits for 24 hours (GLP compliance), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	A slight and transient irritation occurred in a test applied 100 mg to rabbit eyes (GLP compliance), and conjunctival redness of grade 1 only at 1 hour after the application was observed. But no other positive reactions at each observation point up to 7 days were observed. (EU-RAR (2003)) Therefore, it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Not classified	- -	-	-	Because a skin sensitization test using guinea pigs (Magnusson and Kligman test: OECD TG406, GLP) concluded from no sensitizing observation that this substance was not a skin sensitizer (EU-RAR (2003)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	From a negative result in a micronucleus test using peripheral blood and bone marrow after oral administration to mice (in vivo somatic cell mutagenicity test) (NTP DB (Access on July 2011)), it was classified as "Not classified." Besides, as in vitro tests, both an Ames test and a chromosome aberration test using mouse peripheral blood lymphocytes reported negatives (EU-RAR (2003)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	In a oral administration test in pregnant rats during an organogenetic period, there is the information that embryo absorption at a high ratio and significantly increased incidences of rear limb malformation, slight dilatation of the lateral ventricles of the brain, malformation and incomplete ossification of the scapulae were observed at the high dose (25 mg/kg/day) at which decreased weight gain was observed as general toxicity in maternal animals. (EU-RAR (2003)) From the information that it was classified in Repr. Cat. 2; R61 in EU classification because the possibility that these developmental toxicity effects were not related to maternal toxicity was indicated (EU-RAR (2003)), it was classified in Category 1B. Besides, in an oral administration test in rabbits during an organogenetic period, no teratogenicity, but a few cases of early deliveries at a dose where maternal animals showed a decreased weight gain was observed. (EU-RAR (2003))	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	An acute toxicity test by oral administration of 5000 mg/kg to rats (GLP compliance) reported that decreased activity was observed immediately after dosing until 1 hour later, but neither death nor dose-related lesions in final necropsy were observed. (EU-RAR (2003)) Because the findings are observed at a dose much above the upper limit of Guidance values, it is judged to correspond to "Not classified" in an oral route. On the other hand, an acute toxicity test by inhalation exposure (dust) to rats reported that marked toxic symptoms were not found but decreased motor activity and eye squint at 2 mg/L/1h (0.5 mg/L/4h) and tachypnea at 60 mg/L/1h (15 mg/L/4h) were observed. Another test reported crusta in eye and nose in one animal each at 4.33 mg/L/4h after one day. (EU-RAR (2003)) But because all tests do not have further descriptions, it was classified as "Classification not possible" due to lack of data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver), Category 2 (lung)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	Tests using rats found as follows (EU-RAR (2003)): enlarged liver centrilobular or mid-zonal parenchymal cells accompanied by fine granular structures containing round eosinophilic bodies at the dose of 100 ppm (8.1mg/kg/day, a 90-day equivalent: 2.5 to 2.6 mg/kg/day) or higher in 28-day diet administration; granular cytoplasmic changes in liver cells at 100 ppm (7.2 to 8.3 mg/kg/day) or higher and cytoplasmic vacuolization showing fatty generation at 1000 ppm (73.7 to 85.6 mg/kg/day) or higher in 90-day diet administration; focal to multifocal cytoplasmic enlargement in liver cells, focal acidophilic degeneration, and necrosis in the centrilobular regions at 3.7 mg/m3 (a 6-hour-a-day-90-day equivalent 0.767 mg/m3) or higher in a 14-day inhalation exposure (dust); dose-dependent centrilobular hepatocellular hypertrophy at 16 mg/m2 or higher in a 90-day inhalation exposure. Because the doses correspond to a range of Category 1 in Guidance values, it was classified in Category 1 (liver). Furthermore, in a 90-day inhalation exposure (dust) test in rats, alveolar histiocytosis at 202 mg/m3 corresponding to the upper limit of a range of Category 2 in Guidance values, and minimal active chronic inflammation of lung at lower doses were observed. And necropsy reported firmness and enlargement in the bronchial and mediastinal lymph nodes and granulomatous inflammation in these lymph nodes. (EU-RAR (2003)). Therefore, it was classified in Category 2 (lung).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Because all of the algae, crustacea, and fish did not show effects up to a concentration around the water solubility (1.11E-08 mg/L; PHYSPROP Database, 2009), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 4	- -	H413	P273 P501	Chronic aquatic toxicity for algae and crustacea up to a concentration of the water solubility was not reported. Though acute toxicity corresponds to "Not classified" in all of 3 trophic levels, from poor water solubility (water solubility, 1.11E-08 mg/L (PHYSPROP Database, 2009)), lack of rapid degradability (OECD 301C：BOD 0% (EU-RAR, 2003)), and log Kow > 4 (8.71 (PHYSPROP Database, 2009)), it was classified in Category 4.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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